Results 81 to 90 of about 145,429 (283)
Advanced Science, EarlyView.This study identifies the HDAC6/GATA4/HtrA1 axis as a critical driver of cellular senescence in the inner ear. GATA4 nuclear translocation, facilitated by HDAC6 downregulation, transcriptionally activates HtrA1, promoting hair cell senescence, SASP, and audio‐vestibular dysfunction in models of Ménière's disease and age‐related audio‐vestibular ...
Na Zhang +16 more
wiley +1 more source
The Impact of Large-scale Employee Share Ownership Plans on Labour Productivity: The Case of Eircom [PDF]
, 2012 Large-scale Employee Share Ownership Plans (ESOPs) have been a distinctive characteristic of Irish public enterprise reform, with shareholdings of 14.9 per cent being allocated to employees as part of firm restructuring and privatisation programmes. This
McCarthy, Dermot, Palcic, Donal
core +1 more source
Advanced Science, EarlyView.Phospholipase A2 (PLA2), a dormant enzyme, becomes lethal when activated—collapsing lungs in minutes. Our dual therapy (DOPS + varespladib) boosts survival from 0% to >90% in sepsis/ALI. A breakthrough for acute lung injury treatment. ABSTRACT This study reveals that phospholipase A2 (PLA2), normally stable and nontoxic, can be activated specifically ...
Jianyu Wang +7 more
wiley +1 more source
Sharing Ownership via Employee Stock Ownership [PDF]
Broad-based stock options, Employee ownership, Incentive compensation,
Blasi, Joseph R. +2 more
core
Doing Business in the Czech Republic [PDF]
, 2012 [Excerpt] Baker & McKenzie is one of the world’s largest law firms with its presence in 70 locations in 42 countries. We have been active in the Czech Republic since 1993 and our work includes a full range of legal and tax services directed primarily to ...
Baker & McKenzie
core +1 more source
Advanced Science, EarlyView.An iron‐based nanozyme selectively eliminates intratumoral P. anaerobius while catalytically generating ROS to induce ferroptosis, synergistically suppressing colorectal cancer growth and activating anti‐tumor immunity through immunogenic cell death. ABSTRACT The intratumoral microbiota is a critical determinant of therapeutic outcomes in colorectal ...
Yinghao Cao +11 more
wiley +1 more source
The Role of Company Stock in Defined Contribution Plans [PDF]
This paper explores the risks and benefits of holding company stock in employer-sponsored defined contribution (DC) retirement plans. We address three questions: (1) What is the role and function of company stock in such plans?
Olivia S. Mitchell, Stephen P. Utkus
core
Exercising Authority, Restoring Accountability: AFL-CIO Proxy Voting Guidelines [PDF]
, 2003 [Excerpt] We are pleased to provide trustees of union benefit funds with revised AFL-CIO Proxy Voting Guidelines. These Guidelines have been updated to reflect major regulatory reforms enacted in 2002 and 2003, and to further raise the bar on corporate ...
AFL-CIO
core +1 more source
Causal Prediction of TP53 Variant Pathogenicity Using a Perturbation‐Informed Protein Language Model
Advanced Science, EarlyView.A TP53‐specific predictor, CaVepP53, is developed by fine‐tuning ESMC on experimentally validated variants, quantifying pathogenicity via Euclidean distances. It outperforms general‐purpose models and extends to five cancer genes, enabling interpretable variant classification for precision medicine.
Huiying Chen +15 more
wiley +1 more source