Results 111 to 120 of about 1,042,888 (318)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

The Pension Tangle: Achieving Greater Uniformity of Pension Legislation and Regulation in Canada [PDF]

Canada’s maze of differing pension regulations by province and territory discourages the creation of national, single-employer pension plans. Four options for reform – and greater harmonization – should be on the table.Pension Papers, single-employer ...
Gretchen Van Riesen
core  

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Obstacle at Employee’s Work in the Performance of Trade Union Function [PDF]

Societas et Iurisprudentia, 2017
The scientific paper deals with an analysis of the relevant provisions of the Labour Code of the Slovak Republic concerning providing the working time off for employees to perform a trade union function.
Marek Švec, Simona Schuszteková, Adam Madleňák   +2 more
doaj  

Employer Attitudes, the Marginal Employer and the Ethnic Wage Gap [PDF]

Ethnic minorities have lower wages compared to the ethnic majority in most EU-countries. However, to what extent these wage gaps are the result of prejudice toward ethnic minority workers is virtually unknown.
Carlsson, Magnus, Rooth, Dan-Olof
core  

Does Autoenrollment Affect Employer Contributions? [PDF]

, 2009
Summarizes research on how automatically enrolling employees in 401(k) plans in order to raise participation rates increases costs for employers and affects their matching contribution rates and, in turn, the retirement security of eligible ...
Barbara A. Butrica, Mauricio Soto
core   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

The Reasons for the Lack of Interest in the University as an Employer among young Potential Employees and their Changes in 2016–2018

Marketing of Scientific and Research Organizations, 2018
The article is theoretical-empirical in character. In the theoretical part on the basis of the results of cognitive-critical analysis of literature on the subject the chosen aspects associated with the role of the university as an employer and with the ...
Baruk Agnieszka Izabela
doaj   +1 more source

BLS Spotlight on Statistics: Employer-Sponsored Healthcare Coverage Across Wage Groups [PDF]

, 2017
[Excerpt] In March of 2016, a little more than half of all private industry employees participated in employer-sponsored healthcare benefit plans. However, workers earning different wages often have markedly different experiences with healthcare benefits.
Wile, David
core   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source