Results 211 to 220 of about 3,965,762 (361)

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

Psychosocial Workplace Environments Enabling Sustainable Employment for People with Mental Health Conditions: A Scoping Review. [PDF]

Nurs Rep
Fukuura Y, Shigematsu Y, Mizuochi Y.
europepmc   +1 more source

Graduate employability and employment

, 2023
openaire   +1 more source

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Workload perception and job satisfaction among Lebanese practicing dietitians: A cross-sectional study by employment location. [PDF]

PLoS One
Daher M, Serhan C, Chedid R, Serhan M.
europepmc   +1 more source

Employment Guarantee Programs: A Survey of Theories and Policy Experiences [PDF]

, 2007
Fadhel Kaboub
openalex  

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

Absence of a Written Employment Contract and Health Outcomes Among Employed Adults in Chile. [PDF]

Int J Environ Res Public Health
Bravo-Rojas G, Páez-Guajardo M, Viviani C, Castellucci I.   +3 more
europepmc   +1 more source

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

Return to work outcomes in solid organ transplant recipients: A protocol for a global scoping review. [PDF]

PLoS One
Pereira VA, Martinez WD, Santos-Neto MFD, Molina TC, Duca WJ, Arroyo-Júnior PC, Fortunato AC, Sciarra AMP, Stefani AK, Quitério AB, Lopes SMM, Lopes LOM, Lázaro LB, Custódio FC, Bistafa IAA, Rocha JNF, Menezes JDS, Silva MQD, Santos ERD, Borges LPS, Silva GG, Paschoal VDA, Bianchin MA, Spessoto LCF, Caldas HC, Facio Júnior FN, André JC, Silva RFD.   +27 more
europepmc   +1 more source