Results 121 to 130 of about 1,016,717 (292)

Vorinostat Potentiates Chemoimmunotherapy in Immune‐Enriched Pancreatic Cancer

Advanced Science, EarlyView.
Immune‐enriched pancreatic cancer does not confer a significant survival advantage. SAHA sensitizes these “hot” tumors to chemoimmunotherapy by disrupting a FASN/PARP9‐driven “metabolic trap” and enhancing CD8+ T cell function. A CD8high/FASNhigh/PARP9high signature identifies patients who are most likely to benefit from the “gemcitabine‐nivolumab‐SAHA”
Chen Chen, Dingru Li, Yingna Liao, Zehua Wang, Chunbin Zhu, Zifeng Zhang, Liquan Jin, Yueyue Chen, Jiaoshun Chen, Junyi Xu, Miaoyan Wei, Rong Tang, Xianjun Yu, Si Shi   +13 more
wiley   +1 more source

Leveraging Artificial Intelligence and Large Language Models for Cancer Immunotherapy

Advanced Science, EarlyView.
Cancer immunotherapy faces challenges in predicting treatment responses and understanding resistance mechanisms. Artificial intelligence (AI) and machine learning (ML) offer powerful solutions for cancer immunotherapy in patient stratification, biomarker discovery, treatment strategy optimization, and foundation model development.
Xinchao Wu, Mengtao Sun, Lusheng Li, Jieqiong Wang, Shibiao Wan   +4 more
wiley   +1 more source

Adult Sex Ratio as a Demographic Feedback Linking Mating Systems, Parental Care, and Evolution

Advanced Science, EarlyView.
Breeding systems are some of the most diverse social behavior, and our team is investigation the evolutionary causes of this diversity. This review summarises our research carried out at the University of Bath. We argue that demographic components of wild populations, especially the adult sex ratio, plays a key role driving breeding system variation ...
Tamás Székely, Oscar G. Miranda
wiley   +1 more source

To Schedule or Not To Schedule? Agentic and Cooperative Teams at Call Centers

Frontiers in Psychology, 2014
Danilo eGarcia, Danilo eGarcia, Erik eLindskär, Trevor eArcher, Trevor eArcher   +4 more
doaj   +1 more source

Intergenerational effects of parental positive childhood experiences on social skills development in Chinese preschoolers: the moderating role of the home-rearing environment

Frontiers in Psychology
BackgroundWhile the detrimental intergenerational effects of adverse childhood experiences (ACEs) are well-documented, the potential developmental benefits associated with parental positive childhood experiences (PCEs) warrant further clarification ...
Xinyi Yuan, Zhu Zhu, Yanlin Wang, Ruifeng Zhao, Yixin Sun, Xiang Li, Haotian Gao, Tokie Anme   +7 more
doaj   +1 more source

Multimodal Wearable Biosensing Meets Multidomain AI: A Pathway to Decentralized Healthcare

Advanced Science, EarlyView.
Multimodal biosensing meets multidomain AI. Wearable biosensors capture complementary biochemical and physiological signals, while cross‐device, population‐aware learning aligns noisy, heterogeneous streams. This Review distills key sensing modalities, fusion and calibration strategies, and privacy‐preserving deployment pathways that transform ...
Chenshu Liu, Haolin Fan, Minwoo Kim, Tong Zhou, Pinyi Yang, Lingdi Zhao, Yiran Wang, Ziyuan Che, Chia‐Wei Liu, Bingbing Li, Yangzhi Zhu   +10 more
wiley   +1 more source

Empowering children in politics: evaluating a participative democratic programme [PDF]

, 2017
The objective of this study was to evaluate a participative democracy programme called Ágora infantil, carried out with students between the ages of 10 and 12.
Domínguez-Fuentes, Juan Manuel, García-Leiva, Patricia, Hombrados-Mendieta, Isabel, Morales-Marente, Elena, Palacios-Gálvez, María Soledad, Rodríguez-Pascual, Iván   +5 more
core  

Mechanoadaptation via Myosin Cytoplasmic Redistribution Protects Circulating Tumor Cells From Shear‐induced Death During Hematogenous Dissemination

Advanced Science, EarlyView.
This study investigates how CTCs survive varying shear stress during hematogenous metastasis. We uncover a self‐protection mechanism, by which non‐adherent CTCs adapt to high shearing milieu through accumulated cytoplasmic myosin‐mediated disruption of myosin‐actin binding, attenuating force transmission into chromatin to protect CTCs from shear ...
Cunyu Zhang, Qianchun Wang, Keming Li, Guanshuo Hu, Ying Xin, Kai Tang, Bing Hu, Pengyu Du, Renwei Mao, Baohua Ji, Youhua Tan   +10 more
wiley   +1 more source

The Moderating Effects of Power Distance and Individualism/Collectivism on Empowering Leadership, Psychological Empowerment, and Self-Leadership in International Development Organizations

, 2018
The importance of finding appropriate leadership styles to use in cross-cultural situations is paramount. Development organizations and multinational organizations both struggle to find forms of leadership that are effective in mobilizing the workforce ...
Rahschulte, Tim, Thomas, Debby
core   +1 more source

From sari to salwar kameez : changes in the lives of female garment workers in Bangladesh : a thesis presented in partial fulfilment of the requirements for the degree of Master of Philosophy in Development Studies at Massey University [PDF]

, 2003
This thesis aims to give voice to what female garment workers attending the Working Women's Education Centre in Dhaka, Bangladesh perceive as personal changes that have occurred in their lives since taking up employment in the Ready Made Garment Industry.
Hayes-Smith, Julienne
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