Results 81 to 90 of about 127,611 (289)

A Multi-Heuristic Approach for Solving the Pre-Marshalling Problem

open access: yes, 2014
Minimizing the number of reshuffling operations at maritime container terminals incorporates the Pre-Marshalling Problem (PMP) as an important problem.
Jovanovic, Raka   +2 more
core   +1 more source

ATG4B is required for mTORC1‐mediated anabolic activity and is associated with clinical outcomes in non‐small cell lung cancer

open access: yesFEBS Open Bio, EarlyView.
The relationship between anabolic and catabolic processes governing lung cancer cell growth is nuanced. We show that ATG4B, an autophagy regulator, is elevated in lung cancer and that high ATG4B is associated with worse patient outcomes. Targeting ATG4B in cells reduces growth, protein synthesis, and mTORC1 activity, demonstrating a new relationship ...
Patrick J. Ryan   +6 more
wiley   +1 more source

Design of a network of reusable logistic containers [PDF]

open access: yes
In this paper, we consider the management of the return flows of empty logistic containers that accumulate at the customer’s sites. These containers must be brought back to the factories in order to sustain future expeditions.
LANGE, Jean-Charles, SEMAL, Pierre
core  

Autophagosome marker, LC3, is released extracellularly via several distinct pathways

open access: yesFEBS Open Bio, EarlyView.
This study establishes a novel HiBiT‐tagging system for ultrasensitive detection of LC3, revealing multiple pathways for its extracellular secretion. It demonstrates that LC3 is released via both autophagy‐dependent and ‐independent mechanisms, including a novel route for nonlipidated LC3‐I.
Koki Saito   +3 more
wiley   +1 more source

A three-phase heuristic for a multi-size container transport problem with partially specified requests

open access: yes, 2016
The present paper studies a generalization of the less-than-truckload pickup and delivery problem. The problem at hand arises in the hinterland of container terminal where empty and loaded containers have to be transported between a container depot and a
Buer, Tobias   +2 more
core  

Vol. 19, No. 2: Illinois Pesticide Review [PDF]

open access: yes, 2006
published or submitted for publicationnot peer ...
University of Illinois Extension
core  

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

open access: yesFEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava   +3 more
wiley   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

open access: yesFEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani   +6 more
wiley   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

open access: yesFEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point   +7 more
wiley   +1 more source

REVERSE LOGISTICS OF AGROCHEMICAL PESTICIDE PACKAGING AND THE IMPACTS TO THE ENVIRONMENT

open access: yesBrazilian Journal of Operations & Production Management, 2016
: Over time, agriculture has proven to be an important economic development factor for Brazil. The evolution and the need for productivity caused a large increase in the use of pesticides in agriculture and with it, the need to give proper treatment to ...
Mario Fernando Mello, Rosangela Scapini
doaj   +1 more source

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