Results 31 to 40 of about 40,617 (277)
The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes
FEBS Letters, EarlyView.Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga +3 more
wiley +1 more source
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
FEBS Letters, EarlyView.Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai +4 more
wiley +1 more source
, 2013 Empty names are names which do not refer to anything. Apparently empty names are used in many different ways, and an analysis which looks good for one kind of use can look bad for another. I aim to get a wide enough angle on the issues that the solutions
Bench-Capon, Michael G. T.
core
Levantamento das omissões ortográficas na escrita infantil
Texto Livre: Linguagem e Tecnologia, 2015 This work deals with omissions on written productions of children who are in elementary school, at the 3rd and 4th school years. We adopted for this work the same methodological procedures of Chacon (2010) and Amaral et al. (2011).
Regina Célia Fernandes Cruz
doaj +3 more sources
Zakorzenienie umysłu w obiektach abstrakcyjnych (The Mind's Anchorage in Abstract Objects) [PDF]
Analiza i Egzystencja, 2010 Some features of human linguistic competence make one to reconsider the Fregean notion of modes of presentation, which were supposed to correspond to senses of words.
Robert Piłat
doaj
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Vacuous names in early analytic philosophy:Frege, Russell, and Moore [PDF]
, 2016 Empty proper names give rise to intriguing questions. Frege, Moore and Russell stand at the beginning of analytic philosophy's engagement with these questions.
Textor, Mark; id_orcid
core +1 more source
Викладання мов у вищих навчальних закладах освіти на сучасному етапі: Міжпредметні зв'язки, 2022 The paper presents the results of the analysis of experimental research data in this area. Over a long period of observation, the author studied two groups of subjects of different age categories with diverse social characteristics, using the oral ...
L. Chernovaty
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An Analysis on the Art Programs of Universities and Higher Education Institutes under the Direct Administration of the Ministry of Science, Research and Technology [PDF]
پیکره, 2020 It has been more than seventy years since the first art school in Iran was officially established under the auspices of higher education. Since then, art disciplines have emerged in many sections of the nation under the names of specialized universities,
Mansour Kolahkaj, Elham Abdolahpour
doaj +1 more source