Results 71 to 80 of about 160,476 (272)

Cardiovascular‐Kidney‐Metabolic Syndrome in People With HIV: An Emerging Frontier for Clinical Pharmacology

Clinical Pharmacology &Therapeutics, EarlyView.
As antiretroviral therapy (ART) prolongs lifespans, people with HIV (PWH) face a new syndemic: Cardiovascular‐Kidney‐Metabolic (CKM) syndrome. Yet CKM in PWH is poorly characterized. Inflammation, complex pharmacokinetic (PK) alterations, ART‐associated metabolic effects, and gut dysbiosis amplify risk. Managing CKM increases medication burden, thereby
Aaron S. Devanathan, Thomas D. Nolin
wiley   +1 more source

Clinical Safety of Extended Interval Dosing of Nivolumab in Patients with Melanoma

Clinical Pharmacology &Therapeutics, EarlyView.
Extended interval dosing regimens of immune checkpoint inhibitors have been implemented widely. However, their approval was mainly based on pharmacokinetic modeling and simulations. Consequently, comparative safety data of extended interval dosing regimens in a real‐world setting are limited.
Ruben Malmberg, Maaike M. Hofman, Fatima Ashad, Alaa Daloul, Stefani Oosterveld, Edwin A. Basak, Esther Oomen‐de Hoop, Astrid A. M. van der Veldt, Arjen Joosse, Roelof W. F. van Leeuwen, Ron H. J. Mathijssen   +10 more
wiley   +1 more source

Major Adverse Cardiac Events with Ondansetron: A Systematic Review

Clinical Pharmacology &Therapeutics, EarlyView.
Evidence base: 170 randomized trials, 23,421 adults, predominantly single‐dose IV ondansetron, mean follow‐up 20 days. Observed outcomes: Major adverse cardiac events were rare, no ventricular arrhythmias or torsades de pointes observed. Conclusion: Ondansetron was not associated with increased mortality or serious cardiac arrhythmias in adult ...
Michael Cristian Garcia, Bhavya Gandhi, Faisal Quadri, Mahnoor Shahab, Kassie Rong, Genevieve Ramnarine, Ishleen Sudan, Sophia Zhang, Michelle Yu, Sara Mojdehi, Lawrence Mbuagbaw, Anne M. Holbrook   +11 more
wiley   +1 more source

Usefulness of information and communication technology to physicians in tertiary health institutions in Southeastern Nigeria

International Journal of Medicine and Health Development
Background: The adoption of e-platforms for use in clinical and administrative processes within health facilities in many African countries has been slow.
Frances N Madu, Anazoeze J Madu, Ngozi I Ugwu, Clare I Ajuba, Alozie Eze, Richard Okebaram, Kenechi A Madu, Mazi O Eze   +7 more
doaj   +1 more source

Pragmatic, Interdisciplinary Perspectives on Blockchain and Distributed Ledger Technology: Paving the Future for Healthcare

Blockchain in Healthcare Today, 2018
Background: Blockchain and distributed ledger technology is a disruptive force in healthcare. Methods: This article provides a globally relevant, interdisciplinary perspective intended to aid disparate group of actors, participants, and users that ...
Ron Ribitzky, James St. Clair, David I Houlding, Chrissa T McFarlane, Brian Ahier, Michael Gould, Heather L Flannery, Erik Pupo, Kevin A Clauson   +8 more
doaj   +1 more source

An optimizing microseismic method for rock burst early warning based on mining production process

Deep Underground Science and Engineering, EarlyView.
A classification early warning method of rock burst based on hourly microseismic data is proposed, which can be combined with the on‐site production process to provide more timely warning. Abstract Microseismic (MS) events have been reported in nearly every coal mining country, which could well lead to rock burst in underground coal mines.
Zepeng Han, Linming Dou, Wu Cai, Mingbo Chi, Guojun Xi, Shuai Chen, Biao Jiao   +6 more
wiley   +1 more source

Toward Application of Blockchain for Improved Health Records Management and Patient Care

Blockchain in Healthcare Today, 2019
Technological advancements have proven to be indispensable for improving patient care, yet they continue to present a host of problems. One of the most pressing concerns is how to improve quality of care while controlling costs. Beyond clinical care, one
Gracie Carter, Denise White, Anusha Nalla, Hossain Shahriar, Sweta Sneha   +4 more
doaj   +1 more source

The difficult discussion on the deactivation of implantable cardioverter devices at the end of life: a systematic review

ESC Heart Failure, Volume 12, Issue 2, Page 733-760, April 2025.
Abstract Implantable cardioverter defibrillators (ICDs) reliably prevent death due to life‐threatening arrhythmias; this may become less relevant in people with more severe heart failure who are reaching the end of life (EOL). This review aimed to explore the ICD deactivation process and identify ethical issues, especially around the initiation of ...
Siobhan C. Murray, Claire McNamara, Anna V. Chatzi   +2 more
wiley   +1 more source

Sentara Healthcare: A Case Study Series on Disruptive Innovation Within Integrated Health Systems [PDF]

, 2011
Examines how integration and ties with health plans, physicians, and hospitals helped protect against revenue volatility and enabled experimentation; factors that facilitate integration; innovative practices; lessons learned; and policy ...
Rosie O'Donnell, Vineeta Vijayaraghavan
core  

Optimal approach to standardized documentation in epilepsy clinics: A scoping review

Epilepsia, EarlyView.
Abstract Clear documentation and transfer of information between health care providers is key to ensuring the delivery of high‐quality patient care. Our aim was to determine how to optimize and standardize physician documentation in outpatient epilepsy clinics as well as to highlight challenges and barriers to their implementation.
Shahab Marzoughi, Maren Kimura, Bamby Joseph, Alina Zhao, Diane L. Lorenzetti, Dang K. Nguyen, Mark Keezer, Colin B. Josephson, Nathalie Jetté   +8 more
wiley   +1 more source