Results 181 to 190 of about 68,174 (219)

A Biofabricated Human Acinus‐on‐a‐Chip Unveils Mechanotransductive Drivers of Ventilator‐Induced Lung Injury via Decoupling Volutrauma and Barotrauma

Advanced Science, EarlyView.
This bioinspired acinus‐on‐a‐chip recapitulates VILI pathology, revealing that volutrauma drives P53/NF‐κB pathways while barotrauma triggers mitochondrial‐Wnt dysregulation. A fibrotic transitional cell cluster was identified. Pharmacological interventions targeting these pathways significantly ameliorated injury, establishing a mechanobiological ...
Heng Lu, Liansheng Liu, Zengyong Hu, Shuxian Fang, Ruohan Ren, Sidi Liu, Meng Zhao, Zhiting Luo, Ziyue Zhang, Wenlong Shao, Qian Liu   +10 more
wiley   +1 more source

Fzd7 Restrains Pink1‐Dependent Mitophagy in Suture Stem Cells to Maintain Cranial Suture Patency

Advanced Science, EarlyView.
How suture stem cells fail to preserve cranial suture patency remains incompletely understood. Integrated single‐cell and high‐resolution spatial transcriptomic analyses identify reduced Fzd7 expression in Prrx1+ suture stem cells as an early feature of craniosynostosis.
Xinyan Chen, Zong Chen, Chenzhi Lai, Yingying Yue, Tian He, Hao Gong, Jing Shi, Xiaoshuang Guo, Yu Wang, Guodong Song, Xiaolei Jin   +10 more
wiley   +1 more source

Uncoupling Type I Interferon Benefits From Inflammatory Toxicity: Transformer‐Prioritized Precision Agonists for Potent and Safer Cancer Immunotherapy

Advanced Science, EarlyView.
A Transformer‐based AI framework, DLINP, screens millions of compounds to identify Co68, a cobalt‐pincer organometallic complex that biases TLR4‐MD2 signaling toward antitumor interferon activation while suppressing inflammatory toxicity through an early TLR4‐SYK‐STAT1 axis.
Xuefei Guo, Yang Zhao, Xianle Rong, Xingyu Chen, Xiao Wang, Tianyi Liu, Yunfei Xie, Yushu Zou, Pingsen Zhao, Qiang Liu, Fuping You   +10 more
wiley   +1 more source

Influence of endometriosis on the outcomes of assisted reproductive technology in poor ovarian responders with previous implantation failures. [PDF]

Obstet Gynecol Sci
Oh S, Lee S, Chun S, Park TW, Joo JH, Koo YH, Lee YC.   +6 more
europepmc   +1 more source

Compact 9dBEs Enable Efficient and Precise Genome Editing in Mammalian Cells and In Vivo

Advanced Science, EarlyView.
As a compact type II‐D system, the Cas9d‐based platform holds great potential for in vivo applications. Through rational engineering, its derived base editors (9dBEs) enable efficient disease modeling while facilitating single‐vector AAV delivery for in vivo genome editing. These miniature tools offer a robust strategy for basic research and biomedical
Qingquan Xiao, Zhijin Tian, Luqi Weng, Kun Xu, Dingyi Han, Zhaowei Wu, Junnan Li, Shangpu Li, Qijing Zhang, Xiaohui Zhao, Guoling Li, Yinghui Wei, Zhen Gu   +12 more
wiley   +1 more source

Curcumin Alleviates Endometriosis in Sexually Mature Female Mice by Targeting PKA and Inhibiting De Novo Estrogen Synthesis. [PDF]

Biomedicines
Zhao H, Chen X, Zhang S, Zhang J, Wang Y, Xia Z, Wang H, Xu Z.   +7 more
europepmc   +1 more source

Racial and ethnic differences in time to shock delivery in out-of-hospital cardiac arrest. [PDF]

Resusc Plus
Shimabukuro A, Komukai S, Shiba K, Blewer AL, Aufderheide TP, Carlson JN, Elmer J, Idris AH, Lupton JR, Martin-Gill C, Mohamed A, Nichol G, Owusu-Ansah S, Ramgopal S, Stephens SW, Wang HE, Callaway CW, Okubo M.   +17 more
europepmc   +1 more source

Locations of emergency medical services attended non-fatal opioid-involved overdoses, 888 counties, USA, 2022-2024. [PDF]

Inj Prev
Lyons BC, Faherty EAG, Park J, Walters J, Casillas S, Ko JY, Lee SH.   +6 more
europepmc   +1 more source

Single-Cell RNA Sequencing Shows Markedly Elevated Immune Cell Proportions in the Endometrium of Women with Endometriosis-A Narrative Review. [PDF]

Int J Mol Sci
Riaz MA, Zeppernick F, Zeppernick M, Meinhold-Heerlein I, Konrad L.   +4 more
europepmc   +1 more source