Results 271 to 280 of about 338,860 (400)

Neoadjuvant Chemotherapy With Cisplatin Up‐Regulates GSDMD to Enhance Oral Squamous Cell Carcinoma Metastasis Through MMP14‐Mediated EMT Activation

Advanced Science, EarlyView.
Oral squamous cell carcinoma cells exhibit upregulated expression of GSDMD upon exposure to low‐dose cisplatin chemotherapy, which subsequently interacts with MMP14 through its N‐terminal domain, activating the epithelial‒mesenchymal transition (EMT) process and promoting the lymph node metastasis of oral squamous cell carcinoma.
Zixian Huang, Qiming Jiang, Qianyu Zhang, Nan Lu, Xi Rui, Rui Chen, Yan Wang, Yuepeng Wang, Xiaoding Xu, Zhiquan Huang   +9 more
wiley   +1 more source

A thinner endometrium is associated with a greater risk of preterm delivery after fresh cleavage embryo transfer but not after blastocyst transfer: a retrospective cohort study of 11,111 singleton live births. [PDF]

Front Endocrinol (Lausanne)
Ye T, Kong H, Bu Z, Fan W, Du L, Li J, Guo Y.   +6 more
europepmc   +1 more source

BMP4 induces EMT and Rho GTPase activation in human ovarian cancer cells

, 2007
Brigitte L. Thériault, Trevor G. Shepherd, Michelle Mujoomdar, Mark W. Nachtigal   +3 more
openalex   +1 more source

Metformin regulates breast cancer stem cello ntogeny by transcriptional regulation of the epithelial-mesenchymal transition (EMT) status [PDF]

, 2010
Alejandro Vázquez‐Martín, Cristina Oliveras‐Ferraros, Sílvia Cufí, Sonia Del Barco, Begoña Martı́n-Castillo, Javier A. Menéndez   +5 more
openalex   +1 more source

Single‐Cell RNA Sequencing Delineates Renal Anti‐Fibrotic Mechanisms Mediated by TRPC6 Inhibition

Advanced Science, EarlyView.
Single‐cell transcriptomics reveals how TRPC6 inhibition alters renal cell composition and gene expression in CKD. The study uncovers a novel endothelial subpopulation (ECRIN), highlights key inflammatory and fibrotic pathways, and identifies a Prnp‐driven network linked to fibrosis resolution, offering mechanistic insight into TRPC6 as a potential ...
Yao Xu, Zhihuang Zheng, Marleen Silke Oswald, Guozhe Cheng, Jun Liu, Qidi Zhai, Ute Kruegel, Michael Schaefer, Holger Gerhardt, Nicole Endlich, Maik Gollasch, Stefan Simm, Dmitry Tsvetkov   +12 more
wiley   +1 more source

Inhibition of HPSE/SDC-2 axis-induced epithelial-mesenchymal transition for treating IC/BPS. [PDF]

PLoS One
Chen Z, He Y, Zhang J, Ge Q, Du T, Fan Z, Zhou J, Yang X, Shen B, Wei Z.   +9 more
europepmc   +1 more source

Constructing the EMT regulatory network of PMCs in sea urchin embryos

, 2007
Shu-Yu Wu, David R. McClay
openalex   +1 more source

A Super‐Enhancer‐Driven Transcriptional Regulatory Circuit Underlying Abiraterone Resistance in Castration‐Resistant Prostate Cancer

Advanced Science, EarlyView.
This study identifies a super‐enhancer‐driven transcriptional regulatory circuit comprising BCL6, SMAD3, and NFIB that cooperate to drive cholesterol synthesis via SREBF2/HMGCR/FDFT1 activation and regulate CDK2/CCND3 for cell cycle control. Targeting this circuit with BI‐3802 or downstream inhibitors (Fatostatin/Lovastatin) overcomes abiraterone ...
Liling Jiang, Jiamin Wang, Guanjie Peng, Haichuan Zhang, Jinxin Fang, Yingyin Gao, Enzhe Lou, Yangzhou Liu, Wa Ding, Bingyuan Liu, Qiong Mao, Lizhen Jiang, Aochu Liu, Xinyue Li, Shiwen Hu, Qiaomin Ma, Yueyuan Zheng, Zhigang Zhao, Xianping Shi   +18 more
wiley   +1 more source

Transforming Cancer Therapy: Unlocking the Potential of Targeting Vascular and Stromal Cells in the Tumor Microenvironment. [PDF]

Cancer Res
Liu L, Zhang Y, Liu H, Yang J, Tian Q, Chueakula N, Ramasamy S, Verma NK, Cheung C, Kusumbe AP.   +9 more
europepmc   +1 more source

The TGFβ-Par6 polarity pathway: Linking the Par complex to EMT and breast cancer progression [PDF]

, 2010
Alicia Viloria‐Petit, Jeffrey L. Wrana
openalex   +1 more source