Results 291 to 300 of about 338,860 (400)

Bispecific Antibody Targeting VEGF/TGF‐β Synergizes with Local Radiotherapy: Turning Tumors from Cold to Inflamed and Amplifying Abscopal Effects

Advanced Science, EarlyView.
Y332D, a bispecific antibody that simultaneously blockades VEGF and TGF‐β, counteracted negative RT effects that are attributed to the upregulation of TGF‐β and VEGF, as well as further enhanced the immunostimulatory effects of RT, thereby reprograming the TME from immune “cold” to inflamed state and forming an effective in‐situ vaccine that eradicate ...
Lijuan Lyu, Ming Yi, Ji Chen, Jing Zhang, Xiaobin Ma, Xiaojun Zhang, Liang Zeng, Yan Xue, Haimei Wen, Yujiao Deng, Pengfei Zhou, Kongming Wu, Huafeng Kang, Zhijun Dai   +13 more
wiley   +1 more source

Modified ZhuJing pill protects retinal pigment epithelium against oxidative stress-induced epithelial-mesenchymal transition through Nrf2-mediated Akt/GSK3β pathway. [PDF]

Front Pharmacol
Yang N, Xiong C, Feng S, Gao M, Zhou S, Hui Q, Zhou X, Jin Q, Shao Y, Xu X.   +9 more
europepmc   +1 more source

Multifunctional Infrared Polarizer Based on Aligned Growth of High‐Density Boron Nitride Nanotubes

Advanced Science, EarlyView.
This paper presents a novel method for the high‐density, aligned growth synthesis and purification of boron nitride nanotubes (BNNTs). The polarization sensitivity and linear dichroism characteristics of BNNTs in the near‐infrared and mid‐infrared bands are comprehensively verified.
Ningqiang Shi, Xiaofei Xiao, Mingyu Zhang, Zhijun Li, Chuncheng Ban, Jinchang Meng, Nannan Shi, Mingyang Wu, Zebo Zheng, Ling Li   +9 more
wiley   +1 more source

Epithelial-to-mesenchymal transition drives cancer genomic instability. [PDF]

J Exp Clin Cancer Res
Carstens JL, Lovisa S.
europepmc   +1 more source

Novel ATR/PARP1 Dual Inhibitors Demonstrate Synergistic Antitumor Efficacy in Triple‐Negative Breast Cancer Models

Advanced Science, EarlyView.
Novel ATR/PARP1 dual inhibitors are developed for the first time. Advanced lead B8 effectively reduces cell viability in vitro and suppresses tumor growth in vivo, with better potency than ATRi and PARPi alone or in combination. Mechanistically, B8 induces apoptosis, arrests the cell cycle, and inhibits cancer cells colony formation, migration, and ...
Yuan Gao, Jiawei Zhou, Chen‐Chen Wang, Zong‐Hao Wang, Nian‐Dong Mao, Meng‐Lan He, Peng‐Peng Zhang, Ping Huang, Guo‐Wei Ye, Yu‐Qing Zhang, Feng‐Hui Tang, Hang Zhang, Tian Xie, Xiang‐Yang Ye   +13 more
wiley   +1 more source

Integrated mathematical and experimental modeling uncovers enhanced EMT plasticity upon loss of the DLC1 tumor suppressor. [PDF]

PLoS Comput Biol
Höpfl S, Özverin M, Nowack H, Tamas R, Clark AG, Radde N, Olayioye MA.   +6 more
europepmc   +1 more source

PTEN impedes EMT during chick embryo gastrulation [PDF]

, 2011
Yan Li, Xiaoyu Wang, Lijing Wang, Tao Xu, Xiao-Ye Lu, Dongqing Cai, Jian-Guo Geng, Xue-Song Yang   +7 more
openalex   +1 more source

RSPO2 Coordinates with GDF9:BMP15 Heterodimers to Promote Granulosa Cell and Oocyte Development in Mice

Advanced Science, EarlyView.
RSPO2 and GDF9:BMP15 heterodimers—core components of oocyte‐secreted factors (OSFs)—coordinate to shape the molecular architecture of preantral granulosa cells via gene‐specific synergistic and antagonistic regulation, mediated through CTNNB1–SMAD2 signaling crosstalk.
Yingmei Wang, Hongjiang Li, Liji You, Shuhui Wang, Jinglei Bie, Ziyang Su, Lanying Shi, You‐Qiang Su   +7 more
wiley   +1 more source

A Novel Inhibitor of Methyltransferase SMYD2, AZ505 Protects Against Peritoneal Fibrosis in Mice. [PDF]

Clin Exp Pharmacol Physiol
Xu T, Cui B, Liu F, Liu M, Hou X, Hong X, Qi H.   +6 more
europepmc   +1 more source

Selective targeting of activating and inhibitory Smads by distinct WWP2 ubiquitin ligase isoforms differentially modulates TGFβ signalling and EMT [PDF]

, 2011
Surinder M. Soond, Andrew Chantry
openalex   +1 more source