Results 301 to 310 of about 338,860 (400)

EMT and Dissemination Precede Pancreatic Tumor Formation

Cell, 2012
A. Rhim, Emily T Mirek, Nicole M. Aiello, A. Maitra, Jennifer M. Bailey, F. McAllister, M. Reichert, G. Beatty, A. Rustgi, R. Vonderheide, S. Leach, B. Stanger   +11 more
semanticscholar   +1 more source

Inhibiting FAT1 Blocks Metabolic Bypass to Enhance Antitumor Efficacy of TCA Cycle Inhibition through Suppressing CPT1A‐Dependent Fatty Acid Oxidation

Advanced Science, EarlyView.
This study demonstrates that mutant FAT1 promotes ASCL2‐driven, CPT1A‐dependent fatty acid oxidation, leading to resistance to CPI‐613‐mediated TCA cycle inhibition in head and neck cancer. In vivo gene depletion of mutant FAT1 with LNP‐sgFAT1 suppresses tumor growth and restores CPI‐613 sensitivity, revealing a targetable metabolic bypass with ...
Fanghui Chen, Jianqiang Yang, David O. Popoola, Fan Yang, Yajie Liu, Dongsheng Wang, Zhaohui S. Qin, Zhengjia Chen, Nabil F. Saba, Zhuo G. Chen, Yamin Li, Yong Teng   +11 more
wiley   +1 more source

Role of Digoxin in Preventing Cigarette Smoke-Induced COPD via HIF-1α Inhibition in a Mouse Model. [PDF]

Int J Chron Obstruct Pulmon Dis
Zhang K, Zhou F, Zhu C, Yuan L, Li D, Wang J, Lu W.   +6 more
europepmc   +1 more source

Androgen deprivation causes EMT in the prostate [PDF]

, 2011
Melanie Clyne
openalex   +1 more source

Mechanistic Foundations of KRAS‐Driven Tumor Ecosystems: Integrating Crosstalk among Immune, Metabolic, Microbial, and Stromal Microenvironment

Advanced Science, EarlyView.
KRAS mutations dynamically remodel the tumor microenvironment (TME), fostering immunosuppression, metabolic symbiosis, and stromal plasticity. This review dissects how oncogenic KRAS variants sculpt TME networks and explores actionable vulnerabilities. Emerging strategies combining KRAS inhibitors and TME‐editing approaches offer potential to dismantle
Jiayao Ma, Shenao Fu, Jun Tan, Ying Han, Yihong Chen, Xiangying Deng, Hong Shen, Shan Zeng, Yinghui Peng, Changjing Cai   +9 more
wiley   +1 more source

EMT induction in normal breast epithelial cells by COX2-expressing fibroblasts. [PDF]

Cell Commun Signal
Kang M, Devarasou S, Sung NJ, Kwon TY, Shin JH.   +4 more
europepmc   +1 more source

Alternative Path to EMT: Regulation of Apicobasal Polarity in Drosophila [PDF]

, 2011
Jormay Lim, Jean Paul Thiery
openalex   +1 more source

LIMK1 as a Novel Kinase of β‐Catenin Promotes Esophageal Cancer Metastasis by Cooperating With CDK5

Advanced Science, EarlyView.
Li et al. innovatively map the kinase‐substrate network in esophageal cancer metastasis. Their study demonstrates that LIM domain kinase 1 (LIMK1) and Cyclin‐dependent kinase 5 (CDK5) synergistically increase the phosphorylation of β‐catenin, thereby activating the Wnt/β‐catenin signaling pathway to promote esophageal cancer metastasis.
Shu‐Jun Li, Zhuo‐Ran Liang, Zhi‐Chao Liu, Xue‐Ping Luo, Jun‐Yi Li, Xiao‐Mei Yu, Xuan‐Zhang Huang, Yan He, Tao‐Yang Xu, Jiao‐Jiao Xu, Shao‐Cong Peng, Yu‐Xiang Song, Yan He, Xiao‐Wan Zhuang, Can‐Can Zheng, Fan Zhang, Alfred King‐Yin Lam, Wei Dai, Ming‐Liang He, Bo Liu, Qi Zhao, Guo‐Liang Lu, Jin‐Bao Liu, Zhen‐Ning Wang, Zhi‐Gang Li, Ze‐Xian Liu, Wen‐Wen Xu, Bin Li   +27 more
wiley   +1 more source

From Defense to Disease: How the Immune System Fuels Epithelial-Mesenchymal Transition in Ovarian Cancer. [PDF]

Int J Mol Sci
Kos M, Mertowska P, Mertowski S, Roliński J, Krasińska-Płachta A, Urbanowicz T, Gogacz M, Grywalska E.   +7 more
europepmc   +1 more source

Sonic Hedgehog Pathway Promotes Metastasis and Lymphangiogenesis via Activation of Akt, EMT, and MMP-9 Pathway in Gastric Cancer [PDF]

, 2011
Young A. Yoo, Myoung Hee Kang, Hyun Joo Lee, Baek‐hui Kim, Jong Kuk Park, Hyun Koo Kim, Jun Suk Kim, Sang Cheul Oh   +7 more
openalex   +1 more source