Results 311 to 320 of about 338,860 (400)

C1q+ Macrophage–Tumor Cell Interaction Promoted Tumorigenesis via GPR17/PI3K/AKT Pathway Induced DNA Hypermethylation in Nasopharyngeal Carcinoma

Advanced Science, EarlyView.
In the TME of NPC, C1q secreted by C1q+ TAMs interacted with GPR17 to activate PI3K/AKT signaling through strengthening GPR17 coupling PI3K and increasing calcium levels in tumor cells. The activated PI3K/AKT signaling further induces DNA hypermethylation to promote the malignancy and stemness of tumor cells.
Yunzhi Liu, Cuicui Huang, Min Luo, Wenfu Lu, Baifeng Zhang, Lu Bai, Shuyue Zheng, Yanan Tan, Shanshan Li, Huali Wang, Lanqi Gong, Xinyuan Guan   +11 more
wiley   +1 more source

Phytotoxic Effects of the Aqueous Extracts of <i>Magnolia biondii</i> Pamp. Flower Litter and the Joint Action of Allelochemicals. [PDF]

Plants (Basel)
Yu Y, Du Y, Dong J, Yin Z, Chen P, Cao L, Yan Z.   +6 more
europepmc   +1 more source

CeiTEA: Adaptive Hierarchy of Single Cells with Topological Entropy

Advanced Science, EarlyView.
CeiTEA, a novel hierarchical clustering algorithm based on topological entropy, effectively captures complex structures underlying data. By constructing an adaptive multi‐nary partition tree, CeiTEA reveals hierarchical structures and local diversifications, outperforming existing methods in clustering accuracy and consistency and providing the ...
Bowen Tan, Shiying Li, Mengbo Wang, Shuai Cheng Li   +3 more
wiley   +1 more source

The Ethiopian emergency medical team: its formation, progress, response experience and opportunities. [PDF]

Front Public Health
Oyugi B, Tadelle N, Gebreyesus A, Lazaro MM, Mbasha JJ, Relan P, Balde T, Salio F, Abtea M, Zeynu N, Okeibunor J.   +10 more
europepmc   +1 more source

Neutrophil‐Mimicking Nanomedicine Eliminates Tumor Intracellular Bacteria and Enhances Chemotherapy on Liver Metastasis of Colorectal Cancer

Advanced Science, EarlyView.
Fusobacterium nucleatum (Fn) enrichment has been identified in colorectal cancer and its liver metastases. This study develops neutrophil‐mimicking nanoparticles with multiple targeting capabilities encapsulating metronidazole and oxaliplatin for antibacterial and anticancer purposes. This approach reverses the epithelial mesenchymal transition process
Yanan Niu, Xu Zhao, Yong Li, Xiaoya Ma, Weifeng Yang, Jie Ma, Wanglin Li, Wei Yuan   +7 more
wiley   +1 more source

Identification and regulation of EMT cells <i>in vivo</i> by laser stimulation. [PDF]

APL Bioeng
Zhao X, Zhu G, Xue M, He H.
europepmc   +1 more source

The E3 Ligase NEDD4L Prevents Colorectal Cancer Liver Metastasis via Degradation of PRMT5 to Inhibit the AKT/mTOR Signaling Pathway

Advanced Science, EarlyView.
Neural precursor cell expressed developmentally down‐regulated gene 4‐like (NEDD4L) prevents colorectal cancer liver metastasis through ubiquitination and degradation of protein arginine methyltransferase 5 (PRMT5). PRMT5 degradation attenuates the methylarginine of AKT1.
Zhewen Dong, Xiaofei She, Junxian Ma, Qian Chen, Yaqun Gao, Ruiyan Chen, Huanlong Qin, Bing Shen, Hua Gao   +8 more
wiley   +1 more source

Activation of the Wnt signaling pathway and its role in epithelial-mesenchymal transition and hepatic fibrosis in alveolar echinococcosis. [PDF]

Front Cell Infect Microbiol
Wu B, Yang Y, Cheng S, Wang Z, Fan H.
europepmc   +1 more source

Downregulation of uPA/uPAR inhibits intermittent hypoxia-induced epithelial-mesenchymal transition (EMT) in DAOY and D283 medulloblastoma cells

, 2010
Reshu Gupta, Chandramu Chetty, Praveen Bhoopathi, Sajani S. Lakka, Sanjeeva Mohanam, Jasti S. Rao, Dzung Dinh   +6 more
openalex   +2 more sources

The Immune Microenvironment: New Therapeutic Implications in Organ Fibrosis

Advanced Science, EarlyView.
This review summarizes recent advances in understanding the immune microenvironment's role in fibrosis, focusing on phenotypic/functional alterations of immune cells and their dynamic interactions with other cellular constituents within tissues. The authors further explore therapeutic opportunities and challenges in targeting immune microenvironment ...
Xiangqi Chen, Chuan Wu, Fei Tang, Jingyue Zhou, Li Mo, Yanping Li, Jinhan He   +6 more
wiley   +1 more source