Results 191 to 200 of about 217,999 (303)

Ribonucleotides Amplify Mitochondrial DNA‐Driven cGAS–STING Activation via FdUMP‐ribonucleotide Hybrid Particles to Potentiate Chemoimmunotherapy

Advanced Science, EarlyView.
This work develops a metabolic sharing strategy that employs cytidine monophosphate (CMP) to competitively reprogram floxuridine (FUDR) pyrimidine metabolism in colorectal tumor cells. Elevated intracellular FdUMP induces nucleotide imbalance, drives mitochondrial DNA release and cGAS‐STING innate immune cascade activation, and potentiates robust ...
Chao Wang, Chenxuan Zhao, Yesong Yao, Zhiwen Zou, Anxin Shi, Zhuo Feng, Mingkang Yang, Yue Yu, Yang Liu, Xuehui Rui, Jinhui Wu   +10 more
wiley   +1 more source

Effects of Myofibrillar Protein-Stabilized Soybean Oil Pre-Emulsions Containing Arabic Gum or Gallic Acid-Grafted Arabic Gum on the Quality Characteristics and Oxidative Stability of Reduced-Animal-Fat Emulsified Sausages. [PDF]

Foods
Liu C, Xu M, Luan Y, Ali K, Sun R, Wang Q, Wu S, Shi Y, Wu M.   +8 more
europepmc   +1 more source

Greener Solvents for the Photoisomerization and Catalytic Heat Release of a Norbornadiene‐Based Molecular Solar Thermal Energy Storage System

Advanced Science, EarlyView.
A Molecular Solar Thermal (MOST) system combining a scalable norbornadiene–quadricyclane photoswitch, a biodegradable solvent, propylene carbonate, and noble and first‐row metal catalysts, is presented. Propylene carbonate boosts photoisomerization quantum yield by 25% compared to toluene, prolongs energy storage by an additional 15 days, and enables ...
Lucien Magson, Helen Hölzel, Rebecca J. Salthouse, Liang Fei, Pedro Ferreira, Vitor A. S. Almodovar, Kasper Moth‐Poulsen, Ignacio Funes‐Ardoiz, Diego Sampedro   +8 more
wiley   +1 more source

Etching-Hydrophobicity Modification of Soybean Dreg Insoluble Dietary Fibers and Their Pickering Emulsion Stabilization Mechanisms. [PDF]

Foods
Ge S, Li H, Wu L, Jing W, Yu H.
europepmc   +1 more source

Multifunctional Zinc Glycyrrhizinate‐Integrated Gel for Enhanced Probiotic Delivery and Alleviation of Acute and Spontaneous Colitis

Advanced Science, EarlyView.
Multifunctional oral delivery system—L. reuteri@ZGM—act as both a carrier and therapeutic adjuvant, providing ROS scavenging, and mucin‐interactive properties tailored to the IBD microenvironment. This bioactive gel safeguards L. reuteri from gastric degradation, enhances mucosal adhesion, and promotes long‐term retention at inflamed sites, thereby ...
Mengyun Peng, Xiaochun Chen, Wei Li, Shu Tang, Jun Zhou, Xia Wu, Dan Yuan, Zhongyan Shan, Junfeng Shi   +8 more
wiley   +1 more source

W/O/W Emulsions as a Strategy to Preserve NADES-Derived Annatto Carotenoids and Enhance the Functional Properties of Potato Starch-Based Active Packaging Films. [PDF]

ACS Omega
Balabram SK, Silva FP, Maniglia BC, Tessaro L.   +3 more
europepmc   +1 more source

The GPX3‐VCAM1 Axis Gates Pro‐Fibrotic Tubule Cell Fate in Hyperuricemic Nephropathy

Advanced Science, EarlyView.
Hyperuricemia induces NLRP3 inflammasome signaling activation and downregulation of GPX3 in proximal tubular epithelial cells, leading to oxidative stress–driven VCAM1 upregulation, emergence of pro‐fibrotic proximal tubule cells, macrophage recruitment, and renal fibrosis.
Yunfei Qi, Qiang Zhao, Yue Lve, Yaming Yuan, Tingting Zhou, Yue Yuan, Dexi Wu, Yifan Tang, Yan Liu, Zhigang Li, Chunping Jiang, Qiurong Ding   +11 more
wiley   +1 more source

Lauric Acid Microemulsions Inhibit <i>Staphylococcus aureus</i> Through Cell Membrane Disruption and Potential Interference with Peptidoglycan Biosynthesis. [PDF]

Foods
Ma P, Zhang R, Li C, He Q, Zhang X, Cai Z.   +5 more
europepmc   +1 more source

Upadacitinib Restrains the Pathogenic Fitness of CD4+ T Cells and Aberrant B Cell Programming in Optic Neuritis

Advanced Science, EarlyView.
Single‐cell profiling and functional perturbation reveal coordinated JAK1‐pSTAT3 downstream programs in optic neuritis, including MCL1‐dependent fitness of pathogenic CD4+ Tem cells and glycolysis‐linked, cholesterol‐sensitive B‐cell responses associated with RORA. Upadacitinib disrupts this reciprocal T‐B‐cell circuit and alleviates neuroinflammation,
Gengchen Jiang, Qi Jiang, Lian Han, Yue Peng, Xingyu Liu, Tong Yang, Hao Huang, Jiaying Liu, Yuan Gao, Hui Yang, Wenjun Zou, Zhaohuai Li, Wenru Su   +12 more
wiley   +1 more source

Interfacial-Bulk Synergistic Stabilization of Dual-Network Emulsion Gels by Protein-Polysaccharide Ternary Biopolymer System. [PDF]

Small
Zheng Y, Liang W, Cao T, Chang H, Liu Z, Kong T, Li L, Guan X.   +7 more
europepmc   +1 more source