Results 1 to 10 of about 119,652 (298)

Enantioselective Reductive Alkenylation of α‐CF2H (‐CF3) Amino Halides: Rapid Access to Chiral α‐CF2H (‐CF3) Allylamines [PDF]

Advanced Science
The incorporation of fluoroalkyl groups into drug candidates has garnered increasing attention in the pharmaceutical industry due to their ability to modulate lipophilicity, permeability, metabolic stability, and binding affinity.
Peng Liu, Kuiliang Li, Yan He, Chen‐Hui Jiang, Ruo‐Xing Jin, Duo‐Duo Hu, Wei‐Cheng Zhao, Xuan Nie, Shang‐Zheng Sun, Xi‐Sheng Wang   +9 more
doaj   +2 more sources

Molecular Dynamics Simulations of Amylose- and Cellulose-Based Selectors and Related Enantioseparations in Liquid Phase Chromatography

Molecules, 2023
In the last few decades, theoretical and technical advancements in computer facilities and computational techniques have made molecular modeling a useful tool in liquid-phase enantioseparation science for exploring enantioselective recognition mechanisms
Roberto Dallocchio, Alessandro Dessì, Barbara Sechi, Paola Peluso   +3 more
doaj   +1 more source

Asymmetric Epoxidation of Olefins with Sodium Percarbonate Catalyzed by Bis-amino-bis-pyridine Manganese Complexes

Molecules, 2022
Asymmetric epoxidation of a series of olefinic substrates with sodium percarbonate oxidant in the presence of homogeneous catalysts based on Mn complexes with bis-amino-bis-pyridine ligands is reported.
Varvara A. Drozd, Roman V. Ottenbacher, Konstantin P. Bryliakov   +2 more
doaj   +1 more source

Daptomycin: A Novel Macrocyclic Antibiotic as a Chiral Selector in an Organic Polymer Monolithic Capillary for the Enantioselective Analysis of a Set of Pharmaceuticals

Molecules, 2021
Daptomycin, a macrocyclic antibiotic, is here used as a new chiral selector in preparation of chiral stationary phase (CSP) in a recently prepared polymer monolithic capillary.
Ali Fouad, Adel A. Marzouk, Montaser Sh. A. Shaykoon, Samy M. Ibrahim, Sobhy M. El-Adl, Ashraf Ghanem   +5 more
doaj   +1 more source

Asymmetric Synthesis of Tetrasubstituted α-Aminophosphonic Acid Derivatives

Molecules, 2021
Due to their structural similarity with natural α-amino acids, α-aminophosphonic acid derivatives are known biologically active molecules. In view of the relevance of tetrasubstituted carbons in nature and medicine and the strong dependence of the ...
Aitor Maestro, Xabier del Corte, Adrián López-Francés, Edorta Martínez de Marigorta, Francisco Palacios, Javier Vicario   +5 more
doaj   +1 more source

Asymmetric additions to dienes catalysed by a dithiophosphoric acid. [PDF]

, 2011
Chiral Brønsted acids (proton donors) have been shown to facilitate a broad range of asymmetric chemical transformations under catalytic conditions without requiring additional toxic or expensive metals.
Hamilton, Gregory, Rauniyar, Vivek, Shapiro, Nathan, TOSTE, F. Dean, Wu, Jeffrey   +4 more
core   +7 more sources

Synthesis of D-Fructose-Based Bifunctional Primary Amine-Thiourea Organocatalysts and Their Applications in Asymmetric Reactions

Chemistry, 2023
The preparation of a new class of six bifunctional thiourea organocatalysts having a D-fructose scaffold and a primary amino group was demonstrated.
Samson Lalhmangaihzuala, Vanlalngaihawma Khiangte, Zathang Laldinpuii, Lal Nunnemi, Joute Malsawmsanga, Gospel Lallawmzuali, Thanhming Liana, Chhakchhuak Lalhriatpuia, Zodinpuia Pachuau, Khiangte Vanlaldinpuia   +9 more
doaj   +1 more source

Enantioselective protonation [PDF]

Nature Chemistry, 2009
Enantioselective protonation is a common process in biosynthetic sequences. The decarboxylase and esterase enzymes that effect this valuable transformation are able to control both the steric environment around the proton acceptor (typically an enolate) and the proton donor (typically a thiol).
Mohr, Justin T., Hong, Allen Y., Stoltz, Brian M.   +2 more
openaire   +3 more sources

Enantioselective Synthesis of N1999A2. [PDF]

ChemInform, 2006
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Nan, Ji, Hardwin, O'Dowd, Brad M, Rosen, Andrew G, Myers   +3 more
openaire   +3 more sources

The Enantioselective Tsuji Allylation [PDF]

Journal of the American Chemical Society, 2004
The first catalytic enantioselective examples of the Tsuji allylation using enol carbonates and enol silanes are described. The products possess a quaternary stereogenic center and are useful building blocks for synthetic chemistry.
Behenna, Douglas C., Stoltz, Brian M.
openaire   +3 more sources