Results 151 to 160 of about 68,215 (297)

Dynamic Regulation of Endogenous Transcription Factor Hubs at Single‐Molecule Resolution

Advanced Science, EarlyView.
This study combines single‐molecule microscopy and genome editing to characterize the dynamic behaviors of endogenous oncofusion transcription factor EWS::FLI1 in Ewing sarcoma cells. EWS::FLI1 forms neomorphic hubs that dynamically assemble and dissolve. The hubs are regulated during mitosis, by RNA, and by specific chemicals.
Shawn Yoshida, Yanghao Zhong, Akiko Kumagai, William G. Dunphy, Shasha Chong   +4 more
wiley   +1 more source

AMAN-DA : Une approche basée sur la réutilisation de la connaissance pour l'ingénierie des exigences de sécurité

, 2015
In recent years, security in Information Systems (IS) has become an important issue that needs to be taken into account in all stages of IS development, including the early phase of Requirement Engineering (RE).
Souag, Amina
core   +1 more source

Gingiva-Derived Decellularised Extracellular Matrix Hydrogel Supports Osteogenic and Angiogenic Phenotypes of 3D STRO-1⁺ GMSC/HUVEC Spheroids In Vitro. [PDF]

Int Dent J
Liu Y, Zheng X, Qiao W, Wen S, Lin Y, Gan Y, Zhao Y, Chen Z, Wang R, Huang X, Rong M.   +10 more
europepmc   +1 more source

Secreted Nonstructural Protein 3 is a Pathogenic Determinant of Orbivirus

Advanced Science, EarlyView.
This study uncovers a conserved PIP2‐dependent secretory pathway of orbivirus NS3 that induces vascular leakage. Pharmacological disruption of PIP2‐NS3 interaction significantly reduces viral pathogenicity and provides protective efficacy in murine models, establishing PIP2‐mediated NS3 secretion as both a key virulence determinant and a promising ...
Junyong Guan, Dong Zhou, Ran Shao, Xing Liu, Jin Peng, Yingran Huang, Shuhui Qi, Cankun Xi, Menghang Wang, Bin Sun, Yinglin Qi, Xin Yin   +11 more
wiley   +1 more source

A knowledge reuse based approach to the domain specific security requirements engineering

, 2015
Au cours de ces dernières années, la sécurité des Systèmes d'Information (SI) est devenue une préoccupation importante, qui doit être prise en compte dans toutes les phases du développement du SI, y compris dans la phase initiale de l'ingénierie des ...
Souag, Amina
core  

WS2 Optoelectronic Memristive Reservoir Enabling Ultra‐Low‐Power, Multi‐Task, and Environmentally Stable Neuromorphic Computing

Advanced Science, EarlyView.
WS2‐based in‐memory sensing reservoir computing integrates sensing, memory, and computation in one compact device. It achieves ∼94% N‐MNIST, ∼93% eye motion perception, and ∼89% speech recognition with ultra‐low energy (∼25.5 fJ/spike). The system shows stability at 95% humidity, endurance over 1.5M cycles, and supports synaptic plasticity, enabling ...
Dayanand Kumar, Hanrui Li, Divyanshu Divyanshu, Dhananjay D. Kumbhar, Manoj Kumar Rajbhar, Amit Singh, Abdul Momin Syed, Selma Amara, Gianluca Setti, Nazek El‐Atab   +9 more
wiley   +1 more source

Case-based computerized examinations for medical students - objective, implementation and experiences

, 2006
Medical students often lack the ability to develop strategies for problem solving based on adequate diagnostic and therapeutic measures. Case studies are an appropriate learning as well as examining tool for this purpose.
Adler, Martin, Dicken, Hans-Dieter, Fischer, Martin R., Adler, M, Rotthoff, Thomas, Dicken, H-D, Fischer, MR, Hege, I, Scherbaum, WA, Baehring, Thomas, Baehring, T, Fahron, U, Fahron, Urte, Scherbaum, Werner A., Rotthoff, T, Hege, Inga   +15 more
core  

Rethinking Mitochondria: The Extracellular Dimension. [PDF]

Circ Res
Pena-Couso L, Makuch M, Nicolas-Avila JA.   +2 more
europepmc   +1 more source

Cucurbit[8]Uril Achieved Single‐Molecule Chiral Transfer to Supramolecular Circularly Polarized Luminescence

Advanced Science, EarlyView.
A single‐molecule cascade supramolecular system comprising L/D‐FPy, CB[8], and SC4AD serves as an efficient light‐harvesting platform. It facilitates cascade energy transfer and chiral transfer to acceptor dyes. Co‐assembly with a PVA matrix produces a multicolor solid film that exhibits enhanced luminescence dissymmetry factors (glum), enabling ...
Yongxue Li, Jie Wu, Weiheng Zhang, Hengzhi Zhang, Wei‐Lei Zhou, Yu Liu   +5 more
wiley   +1 more source

Fostering diagnostic competencies in medical education by implementing the approach of case-based learning through worked-out examples

, 2007
Medical Errors are the fifth leading cause of death in the United States. Among these are also diagnostic errors. An important precondition for an optimal health care for the patient is the right diagnosis.
Kopp, V, Stark, R, Fischer, MR
core