Results 91 to 100 of about 132,871 (277)

Successful Treatment of Human Herpesvirus 6 Encephalomyelitis in Immunocompetent Patient

Emerging Infectious Diseases, 2004
We report the case of human herpesvirus 6 (HHV-6) encephalomyelitis in an immunocompetent patient, which was confirmed by viral amplification from cerebrospinal fluid. Cidofovir was used followed by ganciclovir because of an adverse effect to probenecid.
Eric Denes, Laurent Magy, Karine Pradeau, Sophie Alain, Pierre Weinbreck, Sylvie Ranger-Rogez   +5 more
doaj   +1 more source

A Camelid-Derived STAT-Specific Nanobody Inhibits Neuroinflammation and Ameliorates Experimental Autoimmune Encephalomyelitis (EAE)

Cells
Proinflammatory T-lymphocytes recruited into the brain and spinal cord mediate multiple sclerosis (MS) and currently there is no cure for MS. IFN-γ-producing Th1 cells induce ascending paralysis in the spinal cord while IL-17-producing Th17 cells mediate
Evaristus C. Mbanefo, Allison Seifert, Manoj Kumar Yadav, Cheng-Rong Yu, Vijayaraj Nagarajan, Ashutosh Parihar, Sunanda Singh, Charles E. Egwuagu   +7 more
doaj   +1 more source

Small muscle mass aerobic exercise in health and disease: Unique insights into muscle vascular and metabolic control and performance

Experimental Physiology, EarlyView.
Abstract Studies of small muscle mass exercise (SMME) have revealed that the peripheral O2 transport–utilization cascade is a dynamically regulated system in which perfusive and diffusive components can be selectively amplified, redistributed and mechanically limited depending on contraction pattern, recruitment strategy and intramuscular pressure ...
Shunsaku Koga, David C. Poole, Thomas J. Barstow, Dai Okushima, Richie P. Goulding   +4 more
wiley   +1 more source

Neuroprotective roles of klotho: Molecular pathways and therapeutic implications for cognitive health in neurological and psychiatric diseases

Experimental Physiology, EarlyView.
Abstract Klotho, a pleiotropic protein initially identified for its role in kidney function, has garnered significant attention for its neuroprotective properties in various neurodegenerative diseases. It regulates key processes, such as oxidative stress, neuroinflammation, synaptic plasticity and myelination, all crucial for maintaining neuronal ...
Amir Arsalan Ghahari, Leylinaz Safaeihavadaragh, Mehrdad Nourizadeh, Shaghayegh Davari, Saba Safaei, Farshad Zare, Safa Alkayyat, Erfan Kamali Far   +7 more
wiley   +1 more source

Canonical and non‐canonical functions of proteins regulating mitochondrial dynamics in mammalian physiology

The Journal of Physiology, EarlyView.
Abstract figure legend Mitochondria are highly dynamic organelles that continuously remodel their architecture through coordinated cycles of fusion and fission. This review examines the four key GTPases that orchestrate mitochondrial dynamics in mammals: MFN1, MFN2, OPA1, and DRP1.
Rémi Chaney, Vincent Marcangeli, Krystel Desjardins, Shima Taherkhani, Gilles Gouspillou   +4 more
wiley   +1 more source

Preeclampsia‐derived small extracellular vesicles disrupt blood–brain barrier integrity and activate glial cells in vitro

The Journal of Physiology, EarlyView.
Abstract figure legend This study assessed the impact of plasma‐derived small extracellular vesicles (sEVs) from healthy pregnant women and those diagnosed with late‐onset preeclampsia (PE) on the blood–brain barrier (BBB) integrity and glial cell response. PE patients had higher sEV concentrations than healthy controls.
Julián Henao‐Restrepo, José M. Murrieta‐Coxca, Christian Schmeer, Lingyu Wei, Frank Steiniger, Tanja Groten, Udo R. Markert, Diana M. Morales‐Prieto   +7 more
wiley   +1 more source

Conduction abnormalities are restricted to the central nervous system in experimental autoimmune encephalomyelitis induced by inoculation with proteolipid protein but not with myelin basic protein [PDF]

, 1995
Jonathan B. Chalk, Pamela McCombe, Michael P. Pender   +2 more
openalex   +1 more source

Fatal Human Case of Western Equine Encephalitis, Uruguay

Emerging Infectious Diseases, 2011
Adriana Delfraro, Analía Burgueño, Noelia Morel, Gabriel González, Alicia García, Juan Morelli, Walter Pérez, Héctor Chiparelli, Juan Arbiza   +8 more
doaj   +1 more source

SARS‐CoV‐2 targets mitochondria, exacerbating COVID‐19 pneumonia

The Journal of Physiology, EarlyView.
Abstract figure legend Following entry into airway epithelial cells (AECs), SARS‐CoV‐2 releases its single‐stranded RNA into the cytoplasm, where it is translated into viral proteins. Several of these viral proteins localize to mitochondria and interact with key mitochondrial components.
Danchen Wu, Asish Dasgupta, Jaskaran Singh Hora, Kuang‐Hueih Chen, Arinjay Banerjee, Stephen L. Archer   +5 more
wiley   +1 more source

Diabetes‐related barriers to cancer screening in women with type 2 diabetes: A qualitative interview study

British Journal of Health Psychology, Volume 31, Issue 3, September 2026.
Abstract Objectives People with type 2 diabetes (T2DM) are more likely to develop breast and bowel cancers. Despite this, cancer screening participation is lower among women with diabetes than among women without diabetes, indicating diabetes‐related barriers to screening, but little research has examined this.
Rebecca Spencer, Georgina Jones, Siobhán McHugh, Ramzi A. Ajjan, Rebecca J. Birch, Laura Ashley   +5 more
wiley   +1 more source