Results 131 to 140 of about 309,185 (347)

Identifying Features of Electroencephalography Associated with Improved Awareness in Persistent Vegetative State via Multiscale Entropy: A Machine Learning Modeling Study

Neurotrauma Reports
Accurate differentiation between persistent vegetative state (PVS) and minimally conscious state and estimation of recovery likelihood in patients in PVS are crucial.
Keyun Lai, Xiao Chen, Liyun He, Qi Liu, Changsheng Lai, Yang Bai, Ye Zhang, Kaiyue Wang, Fangzhao Wang, Shuai He, Guangjun Wang   +10 more
doaj   +1 more source

Nonsteroidal Anti‐Inflammatory Drugs as Modulators of Cation Channels: Fenamates Repurposing in Channelopathies

ChemMedChem, EarlyView.
Beyond their established role as nonsteroidal anti‐inflammatory drugs (NSAIDs), fenamates (niflumic, flufenamic, mefenamic, meclofenamic, and tolfenamic acids) have recently been identified as modulators of cationic ion channels. This review highlights their differential effects on ion channel activity and explores their potential for repurposing in ...
Paola Laghetti, Concetta Altamura, Simone Dell’Atti, Jean‐François Desaphy, Ilaria Saltarella   +4 more
wiley   +1 more source

Potential Mechanism and Perspectives of Mesenchymal Stem Cell Therapy for Ischemic Stroke: A Review

Global Medical Genetics
Mesenchymal stem cells (MSCs), as a stem cell type with multiple differentiation potentials and immune regulatory abilities, have shown broad prospects in the treatment of ischemic stroke in recent years.
Pengcheng Zhu, Hongtu Tan, Haobo Gao, Jiabin Wang, Yangyang Liu, Dongyi Yang, Tao Wu   +6 more
doaj   +1 more source

Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Food Effect of Bexicaserin in Healthy Participants: A First‐in‐Human Randomized, Double‐Blind, Placebo‐Controlled Single Ascending Dose Escalation Phase 1 Study

Clinical Pharmacology in Drug Development, EarlyView.
Abstract Bexicaserin (LP352) is a selective 5‐hydroxytryptamine 2C (5‐HT2C) superagonist in development for the treatment of seizures in developmental and epileptic encephalopathies (DEEs). This double‐blind, placebo‐controlled, single ascending dose (SAD) Phase 1 study aimed to assess the safety, tolerability, and pharmacokinetic (PK) and ...
Rosa Chan, Chad Orevillo, Gale O'Connell, Dewey McLin, Shikha Polega, Nuggehally R Srinivas, Randall Kaye   +6 more
wiley   +1 more source

Effect of Jian-Pi-Zhi-Dong Decoction on striatal glutamate and γ-aminobutyric acid levels detected using microdialysis in a rat model of Tourette syndrome

Neuropsychiatric Disease and Treatment, 2016
Wen Zhang,1,* Li Wei,2,* Wenjing Yu,1 Xia Cui,1 Xiaofang Liu,2 Qian Wang,1 Sumei Wang2 1Department of Pediatrics, The Third Affiliated Hospital, 2Department of Pediatrics, Dongfang Hospital, Beijing University of Chinese Medicine, Beijing, People& ...
Zhang W, Wei L, Yu W, Cui X, Liu X, Wang Q, Wang S   +6 more
doaj  

Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Multiple Ascending Doses and Dose Titration of Bexicaserin in Healthy Participants in a Randomized, Double‐Blind, Placebo‐Controlled Study

Clinical Pharmacology in Drug Development, EarlyView.
Abstract Bexicaserin (LP352) is a selective superagonist of the 5‐hydroxytryptamine 2C (5‐HT2C) receptor currently in development for the treatment of seizures that arise from developmental and epileptic encephalopathies. This phase 1, double‐blind, placebo‐controlled multiple ascending dose (MAD) study assessed the safety, tolerability, and ...
Jonathan Williams, Rosa Chan, Chad Orevillo, Gale O'Connell, Dewey McLin, Shikha Polega, Nuggehally R. Srinivas, Randall Kaye   +7 more
wiley   +1 more source

Novel tau filament fold in chronic traumatic encephalopathy encloses hydrophobic molecules

Nature, 2019
B. Falcon, J. Zivanov, Wenjuan Zhang, A. Murzin, H. Garringer, R. Vidal, R. Crowther, K. Newell, B. Ghetti, M. Goedert, S. Scheres   +10 more
semanticscholar   +1 more source

Septic-Associated Encephalopathy: a Comprehensive Review

Neurotherapeutics, 2020
A. Mazeraud, C. Righy, E. Bouchereau, Sarah Benghanem, F. Bozza, T. Sharshar   +5 more
semanticscholar   +1 more source

Da-Chuan-Xiong Decoction Ameliorates Sodium Sensitivity and Plasma Norepinephrine via Attenuation of Brain Oxidative Stress in the DOCA-Salt Hypertensive Rats

International Journal of Hypertension
Background. Da-Chuan-Xiong Decoction (DCXD) is an aqueous extract from a classic Chinese herbal formula composed of dried rhizomes of Ligusticum chuanxiong Hort and Gastrodia elata Bl. in the mass ratio of 4 : 1.
Qi Zhang, Hao Li, Shan Zhao, Fangfang Li, Yingying Tan   +4 more
doaj   +1 more source

ACUTE ENCEPHALOPATHY DURING NEOARSPHENAMINE TREATMENT: A REPORT ON SIX CASES

, 1944
William Young, S. Gordon
openalex   +1 more source