Results 131 to 140 of about 216,601 (314)

L‐Relationship between uncertainty and average seizure frequency in clinical trials of antiseizure medications

Epilepsia, EarlyView.
Abstract Objective Antiseizure medications are approved based on clinical trials that demonstrate their efficacy as measured by reductions in seizure frequency (SF). When designing these trials, trialists must select inclusion criteria where SF can be reliably measured to maintain statistical power.
Wesley T. Kerr, Neo Kok, Katherine N. McFarlane, Advith S. Reddy, Lavanya Biju, Jacqueline A. French, Daniel M. Goldenholz   +6 more
wiley   +1 more source

A case of posterior reversible encephalopathy syndrome in a patient undergoing automated peritoneal dialysis [PDF]

, 2019
Shohei Kaneko, Keiji Hirai, Saori Minato, Katsunori Yanai, Yuko Mutsuyoshi, Hiroki Ishii, Taisuke Kitano, Mitsutoshi Shindo, Akinori Aomatsu, Haruhisa Miyazawa, Kiyonori Ito, Yuichirou Ueda, Taro Hoshino, Susumu Ookawara, Yoshiyuki Morishita   +14 more
openalex   +1 more source

Bovine spongiform encephalopathy infection alters endogenous retrovirus expression in distinct brain regions of cynomolgus macaques (Macaca fascicularis) [PDF]

, 2011
Alex D. Greenwood, Michelle Vincendeau, Ann-Christin Schmädicke, Judith Montag, Wolfgang Seifarth, Dirk Motzkus   +5 more
openalex   +1 more source

Memantine treatment in individuals with GRIN gain‐of‐function variants is associated with improvements in behavior, development, and seizure frequency

Epilepsia, EarlyView.
Abstract Objective GRIN‐related disorders due to pathogenic variants in GRIN1, GRIN2A, GRIN2B, or GRIN2D genes are associated with altered N‐methyl‐D‐aspartate receptor (NMDAR) function. Functional changes include gain (GoF) and loss of receptor function (LoF). Clinical reports describing the use of the NMDAR blocker memantine in GRIN‐related disorders
Maike Karnstedt, Riley E. Perszyk, Scott J. Myers, Ellington McDaniels, Marta Somorai, Ingo Borggraefe, Danielle C. M. Veenma, An‐Sofie Schoonjans, Pasquale Striano, Tadeu A. Fantaneanu, Steffen Syrbe, Kristen Park, Wenjuan Chen, Hongjie Yuan, Stephen F. Traynelis, Timothy A. Benke, Johannes R. Lemke, Ilona Krey   +17 more
wiley   +1 more source

New variants and genotype-phenotype correlation of PPP3CA-related developmental and epileptic encephalopathy [PDF]

Ting Wang, Siyuan Ouyang, Xueyang Niu, Miaomiao Cheng, Ying Yang, Yonghua Yang, Quanzhen Tan, Wenwei Liu, Cheng Yang, Yuehua Zhang   +9 more
openalex   +1 more source

Hepatic encephalopathy [PDF]

Annals of Clinical Biochemistry: International Journal of Laboratory Medicine, 2017
openaire   +2 more sources

Baseline characteristics and feasibility of clinical outcome measures in CDKL5 deficiency disorder: The CANDID observational study

Epilepsia, EarlyView.
Abstract Objective CDKL5 deficiency disorder (CDD) is a rare X‐linked developmental and epileptic encephalopathy caused by loss‐of‐function variants in the CDKL5 gene. Preclinical experiments using enzyme replacement or gene therapies show promise and could be transformative therapies.
Xavier Liogier d'Ardhuy, CANDID Partners, Tricia Cimms, Kristina Lindsten, Marco Rizzo, Alison Skrinar, Peter St. Wecker, Ana Mingorance, Orrin Devinsky   +8 more
wiley   +1 more source

Severe hypotension but not systemic inflammation or endothelial activation predicts encephalopathy in circulatory shock. [PDF]

Ann Intensive Care
Nguyen DN, Huyghens L, Nguyen TM, Schiettecatte J, Diltoer M, Cools W, De Cuyper H, Rhapsorski D, Smitz J, Zhang H.   +9 more
europepmc   +1 more source

Posterior Reversible Encephalopathy Syndrome with Bilateral Independent Epileptic Foci Precipitated By Guillain-Barrè Syndrome [PDF]

, 2016
Rosario Rossi, Maria Valeria Saddi, Alessandro Mela, Anna Ticca   +3 more
openalex   +1 more source

Rapid recovery after intrathecal dexamethasone in FIRES

Epileptic Disorders, EarlyView.
João Filipe Nico, Ana Rita Fradique, Catarina Teixeira, Rita Moinho, Mariana Leitão Marques, Constança Santos, Joana Afonso Ribeiro, Filipe Palavra, Cristina Pereira   +8 more
wiley   +1 more source