Results 281 to 290 of about 351,102 (361)

Accurately identifying cirrhosis and its complications to create the novel statewide Indiana digital cirrhosis registry. [PDF]

Sci Rep
Desai AP, Shamseddeen H, Lembcke L, Hui SL, Nephew LD, Ghabril MS, Orman ES, Chalasani N.   +7 more
europepmc   +1 more source

Effects of fenfluramine and sigma‐1‐dependent pharmacological and genetic modulation in a mouse kindling model

Epilepsia, EarlyView.
Abstract Objective Sigma‐1 is a chaperone protein that serves as a key homeostatic regulator, implicated in neuronal excitability and seizure control. Positive allosteric modulators offer a use‐dependent means to enhance Sigma‐1 activity, potentially with favorable tolerability compared to direct agonists.
Eva‐Lotta von Rüden, Verena Buchecker, Amelie Wagner, Victoria M. Stocker, Liga Zvejniece, Heidrun Potschka   +5 more
wiley   +1 more source

Early-Onset Hyperkinetic Movement Disorders Define the Most Severe Presentation of the ATP8A2-Related Phenotypic Spectrum. [PDF]

Int J Dev Neurosci
Bruschi F, Antonello CE, Parazzini C, Vaia Y, Iascone M, Tonduti D.   +5 more
europepmc   +1 more source

Listening across frequencies: Capturing seizures of all patients to advance antiseizure medication development

Epilepsia, EarlyView.
Abstract Seizure frequency has been the primary endpoint in epilepsy trials, with enrollment usually requiring ≥4 seizures per month. This threshold is more and more misaligned with clinical reality, as the availability of more treatment options has reduced baseline seizure burden, with a risk of excluding a proportion of patients from trials. Although
Stéphane Auvin, Jacqueline French
wiley   +1 more source

Long-Term Neurodevelopmental Outcomes and Prognostic Factors in Neonates with Hypoxic-Ischemic Encephalopathy. [PDF]

J Clin Med
Keçeci R, Büyükeren M, Yılmaz FH, Özcan B, Pamukçu Ü, Yılmaz Ş, Çelik H, Esenkaya Ü.   +7 more
europepmc   +1 more source

Pyruvate dehydrogenase autoantibodies in autoantibody‐negative patients with seizures are associated with reduced pyruvate dehydrogenase activity

Epilepsia, EarlyView.
Abstract Objective We investigated the presence and potential functional relevance of antimitochondrial autoantibodies in patients suspicious for autoimmune encephalitis (AIE) associated with psychiatric symptoms and/or seizures, who were negative for known antineuronal autoantibodies.
Annika Breuer, Chiara A. Hummel, Tobias Baumgartner, Juliane L. Berns, Afaf Milad Said, Isabel Bünger, Susanne Schoch, Gábor Zsurka, Harald Prüss, Wolfram S. Kunz, Rainer Surges, Albert J. Becker, Julika Pitsch   +12 more
wiley   +1 more source

Timing of therapeutic hypothermia and outcomes in neonates with hypoxic-ischemic encephalopathy: A cohort study in a middle-income country. [PDF]

PLoS One
Agudelo-Pérez S, Troncoso G, Gutiérrez Montenegro LM, Ordoñez JL.   +3 more
europepmc   +1 more source

Inherited metabolic epilepsies–established diseases, new approaches

Epilepsia Open, EarlyView.
Abstract Inherited metabolic epilepsies (IMEs) represent the inherited metabolic disorders (IMDs) in which epilepsy is a prevailing component, often determining other neurodevelopmental outcomes associated with the disorder. The different metabolic pathways affected by individual IMEs are the basis of their rarity and heterogeneity.
Itay Tokatly Latzer, Phillip L. Pearl
wiley   +1 more source

Lyme Neuroborreliosis With Acute Encephalopathy Despite Early Antibiotic Therapy: A Case Report. [PDF]

Am J Case Rep
Johannesson JM, Dicks KV, Perkons ME, Cepeda Mora DF, Luedke MW, Ehrlich ME, Houk JL, McKellar MS.   +7 more
europepmc   +1 more source