Results 61 to 70 of about 309,185 (347)

Expanding Hereditary Spastic Paraplegias Limits: Biallelic SPAST Variants in Cerebral Palsy Mimics

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Hereditary spastic paraplegias (HSP) are rare neurodegenerative disorders marked by spasticity and lower limb weakness. The most common type, SPG4, is usually autosomal dominant and caused by SPAST gene variants, typically presenting as pure HSP.
Gregorio A. Nolasco, Mònica Roldán, Yalda Jamshidi, Ioannis Georvasilis, Rocío Jadraque Rodríguez, Reza Boostani, Ali Shoeibi, Lluís Armengol, Anna Codina, Ehsan Ghayoor Karimiani, Cristina Hernando‐Davalillo, Loreto Martorell, María Luisa Ramírez Almaraz, Jordi Muchart, Carlos Ortez, Andrés Nascimento, Roser Urreizti, Daniel Natera‐de Benito, Mercedes Serrano   +18 more
wiley   +1 more source

Current evidence, clinical applications, and future directions of transcranial magnetic stimulation as a treatment for ischemic stroke

Frontiers in Neuroscience, 2023
Transcranial magnetic stimulation (TMS) is a non-invasive brain neurostimulation technique that can be used as one of the adjunctive treatment techniques for neurological recovery after stroke.
Li Zhou, Yaju Jin, Danli Wu, Yongdan Cun, Chengcai Zhang, Yicheng Peng, Na Chen, Xichen Yang, Simei Zhang, Rong Ning, Peng Kuang, Zuhong Wang, Pengyue Zhang   +12 more
doaj   +1 more source

Functional Hydrogel for Modulating Lipid Droplets and Neuroinflammation in Head Injury

Advanced Functional Materials, EarlyView.
After TBI, elevated cholesterol levels in activated microglia lead to the accumulation of cholesterol esters in lipid droplets, exacerbating neuroinflammation. A β‐cyclodextrin‐conjugated GelMA (βCD‐GelMA) hydrogel is developed to promotes cholesterol efflux and reduces LDL influx, thereby alleviating intracellular cholesterol and lipid droplet buildup.
Feixiang Chen, Yvonne Shen, Yutong Shao, Tenghuan Ge, Haowen Qiao, Shangzhou Xia, Yafei Qu, Yuanpu Chiu, Ying Qin, Zhen Zhao   +9 more
wiley   +1 more source

Cardioprotective effects of polydatin against myocardial injury in diabetic rats via inhibition of NADPH oxidase and NF-κB activities

BMC Complementary Medicine and Therapies, 2020
Background Diabetic cardiomyopathy is a main cause of the increased morbidity in diabetic patients, no effective treatment is available so far. Polydatin, a resveratrol glucoside isolated from the Polygonum cuspidatum, was found by our and others have ...
Ying-Ying Tan, Lei-Xin Chen, Ling Fang, Qi Zhang   +3 more
doaj   +1 more source

Disruption of Sulfur Metabolism and Redox Homeostasis in Staphylococcus aureus Using Mechanically Robust Antibiofilm Ti‐Bi Alloys

Advanced Materials Interfaces, EarlyView.
Titanium (Ti) and bismuth (Bi) are selected as alloying elements for the preparation of the Ti‐Bi binary alloy system. Biofilm formation is found to be inhibited by bismuth through the disruption of sulfur metabolism and redox homeostasis, as well as through the direct downregulation of biofilm‐associated proteins.
Lei Shi, Chen Chen, Fupeng Li, Kexin Liu, Kewei Rong, Tong Xing, Tingxian Guo, Kai Huang, Shengbing Yang, Wentao Lin, Jie Zhao   +10 more
wiley   +1 more source

Traditional Chinese Medicinal Herbs for Treating Post‐Ischemic Stroke Cognitive Impairment Insights From Frequency and Association Analysis

Brain and Behavior
Background This study analyzes medicinal herbs in Traditional Chinese Medicine (TCM) formulations for post‐ischemic stroke cognitive impairment, identifying key herbs, their interactions, and potential therapeutic mechanisms through systematic review ...
Yixia Li, Wenqi Huang, Jing Sun, Wenjuan Li   +3 more
doaj   +1 more source

Association between methylenetetrahydrofolate reductase C677T polymorphism and cerebral small vessel disease: a systematic review and meta-analysis

Frontiers in Neurology
ObjectiveThis systematic review and meta-analysis aimed to evaluate the association between the methylenetetrahydrofolate reductase (5,10-methylenetetrahydrofolate reductase, MTHFR) cytosine (C)677thymine (T) polymorphism and cerebral small vessel ...
Hao-tao Zheng, Hao-tao Zheng, Wen-wen Lai, Jian-jun Wang, Fan-xin Kong, Hao-bin Cai, Song-jun Lin, Xu Wang, Dong-bin Cai, Min Pi, Xiu-de Qin   +10 more
doaj   +1 more source

Chemical Approaches for Array Based Detection of Amyloids

Advanced Sensor Research, EarlyView.
Amyloids are protein aggregates with both pathological and functional roles. Their detection is challenged by structural polymorphism, isoform diversity, and dynamic aggregation behavior. This review presents chemical array‐based sensing strategies that address these complexities, emphasizing fluorescence and colorimetric methods, alongside ...
Paulo M. Simon, Yijia Xu, Amandeep Kaur
wiley   +1 more source

Duration of American Football Play and Chronic Traumatic Encephalopathy

Annals of Neurology, 2019
Chronic traumatic encephalopathy (CTE) is a neurodegenerative disease associated with exposure to contact and collision sports, including American football. We hypothesized a dose–response relationship between duration of football played and CTE risk and
Jesse B. Mez, Daniel H. Daneshvar, Bobak Abdolmohammadi, A. Chua, M. Alosco, Patrick T Kiernan, Laney Evers, Laura Marshall, Brett M. Martin, J. Palmisano, Christopher J. Nowinski, Ian Mahar, Jonathan D. Cherry, Victor E. Alvarez, Brigid Dwyer, B. Huber, T. Stein, L. Goldstein, D. Katz, R. Cantu, R. Au, N. Kowall, R. Stern, M. McClean, J. Weuve, Yorghos Tripodis, A. Mckee   +26 more
semanticscholar   +1 more source

A Prion‐Like Domain in EBV EBNA1 Promotes Phase Separation and Enables SRRM1 Splicing

Advanced Science, EarlyView.
This study discoveries that EBV EBNA1 behaves as a prion‐like protein, verified using cell‐based assays and the Saccharomyces cerevisiae Sup35p prion identification system. The prion‐like domain of EBNA1 drives liquid–liquid phase separation. EBNA1 interacts with the splicing factor SRSF1 to regulate the expression of the SRRM1 splicing isoforms ...
Xiaoyue Zhang, Zhengshuo Li, Run Zheng, Xiang Zheng, Jia Wang, Can Liu, Yangge Wu, Yuqing Wen, Chunlin Ou, Songqing Fan, Chenxiao Xu, Junrui Tian, Qun Yan, Hao Nan, Xiaodong Xu, Hui Wang, Qiu Peng, Jian Ma   +17 more
wiley   +1 more source