Results 41 to 50 of about 181,238 (294)

Sleep Spindles Preferentially Consolidate Weakly Encoded Memories [PDF]

The Journal of Neuroscience, 2020
Sleep has been shown to be critical for memory consolidation, with some research suggesting that certain memories are prioritized for consolidation. Initial strength of a memory appears to be an important boundary condition in determining which memories are consolidated during sleep.
Dan Denis, Dimitrios Mylonas, Craig Poskanzer, Verda Bursal, Jessica D. Payne, Robert Stickgold   +5 more
openaire   +3 more sources

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

The effect of negative and positive emotionality on associative memory: an FMRI study.

PLoS ONE, 2011
In general, emotion is known to enhance memory processes. However, the effect of emotion on associative memory and the underling neural mechanisms remains largely unexplored.
Go Okada, Yasumasa Okamoto, Yoshihiko Kunisato, Shiori Aoyama, Yoshiko Nishiyama, Shinpei Yoshimura, Keiichi Onoda, Shigeru Toki, Hidehisa Yamashita, Shigeto Yamawaki   +9 more
doaj   +1 more source

Molecular determinants of signal transduction in tropomyosin receptor kinases

FEBS Open Bio, EarlyView.
Tropomyosin receptor kinases control critical neuronal functions, but how do the same receptors produce diverse cellular responses? This review explores the structural mechanisms behind Trk signaling diversity, focusing on allosteric modulation and ligand bias.
Giray Enkavi
wiley   +1 more source

The role of lipid metabolism in neuronal senescence

FEBS Open Bio, EarlyView.
Disrupted lipid metabolism, through alterations in lipid species or lipid droplet accumulation, can drive neuronal senescence. However, lipid dyshomeostasis can also occur alongside neuronal senescence, further amplifying tissue damage. Delineating how lipid‐induced senescence emerges in neurons and glial cells, and how it contributes to ageing and ...
Dikaia Tsagkari, Eleftheria Panagiotidou, Nektarios Tavernarakis   +2 more
wiley   +1 more source

Insights Into the Antigenic Repertoire of Unclassified Synaptic Antibodies

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective We sought to characterize the sixth most common finding in our neuroimmunological laboratory practice (tissue assay‐observed unclassified neural antibodies [UNAs]), combining protein microarray and phage immunoprecipitation sequencing (PhIP‐Seq). Methods Patient specimens (258; 133 serums; 125 CSF) meeting UNA criteria were profiled;
Michael Gilligan, John R. Mills, Paulina Vargas, Naveen K. Paramasivan, Connie E. Lesnick, Eati Basal, Surendra Dasari, James P. Fryer, Shannon R. Hinson, Joseph Laporta, Amy Espinal, Dennis Fitzgerald, Carolina Garcia, Anna E. Morenkova, Paola Pergami, Anna Shah, Andrew Knight, Reghann LaFrance Corey, Vanda A. Lennon, Anastasia Zekeridou, Sean J. Pittock, Divyanshu Dubey, Andrew McKeon   +22 more
wiley   +1 more source

Functional segregation of rostral and caudal hippocampus in associative memory

Frontiers in Human Neuroscience
IntroductionThe hippocampus plays a crucial role in episodic memory. Given its complexity, the hippocampus participates in multiple aspects of higher cognitive functions, among which are semantics-based encoding and retrieval. However, the “where,” “when”
Alicia Nunez Vorobiova, Matteo Feurra, Enea Francesco Pavone, Lennart Stieglitz, Lukas Imbach, Victoria Moiseeva, Johannes Sarnthein, Tommaso Fedele, Tommaso Fedele, Tommaso Fedele   +9 more
doaj   +1 more source

The BDNF Val66Met Polymorphism Has No Effect on Encoding-Related Hippocampal Response But Influences Recall in Remitted Patients With Bipolar Disorder

Frontiers in Psychiatry, 2019
Background: Cognitive impairments in bipolar disorder (BD) such as memory deficits are associated with poor functional outcomes and it has been suggested that the brain-derived neurotrophic factor (BDNF) Val66Met polymorphism contributes to individual ...
Lone Diana Hørlyck, Lone Diana Hørlyck, Julian Macoveanu, Maj Vinberg, Lars Vedel Kessing, Hartwig Roman Siebner, Hartwig Roman Siebner, Kamilla Woznica Miskowiak, Kamilla Woznica Miskowiak   +8 more
doaj   +1 more source

Discovery and Targeted Proteomic Studies Reveal Striatal Markers Validated for Huntington's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Clinical trials for Huntington's disease (HD) enrolling persons before clinical motor diagnosis (CMD) lack validated biomarkers. This study aimed to conduct an unbiased discovery analysis and a targeted examination of proteomic biomarkers scrutinized by clinical validation. Methods Cerebrospinal fluid was obtained from PREDICT‐HD and
Daniel Chelsky, Cara Joyce, H. Jeremy Bockholt, Paul A. Rudnick, William H. Adams, Fiona McAllister, Justin W. Smock, Michael A. Newton, Jane S. Paulsen   +8 more
wiley   +1 more source

The Neural Mechanisms of Associative Memory Revisited: fMRI Evidence from Implicit Contingency Learning

Frontiers in Psychiatry, 2020
The literature describes a basic neurofunctional antagonism between episodic memory encoding and retrieval with opposed patterns of neural activation and deactivation, particularly in posterior midline regions. This has been coined the encoding/retrieval
Marco P. Caviezel, Carolin F. Reichert, Carolin F. Reichert, Dena Sadeghi Bahmani, Dena Sadeghi Bahmani, Dena Sadeghi Bahmani, Christoph Linnemann, Caroline Liechti, Caroline Liechti, Oliver Bieri, Stefan Borgwardt, Stefan Borgwardt, Thomas Leyhe, Thomas Leyhe, Tobias Melcher   +14 more
doaj   +1 more source