Results 91 to 100 of about 221,241 (267)
Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis
FEBS Letters, EarlyView.Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee +7 more
wiley +1 more source
The colonial encounter told twice; Parallel accounts of Carl Bock’s 1879 expedition to Borneo
Wacana: Journal of the Humanities of IndonesiaWhen the Scandinavian explorer Carl Bock, commissioned by the Dutch colonial authorities, undertook to make an expedition overland through Borneo in 1879, the island retained a sense of the exotic in the European imagination.
Mikko Toivanen
doaj +1 more source
FEBS Letters, EarlyView.Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Living With Difference – Interventions for Just Cities
Nordic Journal of Migration Research, 2021 Marit Aure, Anniken Førde
doaj +1 more source
Freedom, Spontaneity, and Our Encounters
Political PhilosophyThis article defends the significance of our encounters on the grounds of their distinctive contribution to our freedom. The variety and novelty of our encounters, and the spontaneity they allow us in the shaping of our selves, creates opportunities for ...
Emily McTernan
doaj +2 more sources
Introduction: Encounters [PDF]
European journal of American studies, 2016 Roudeau, Cécile, Quanquin, Hélène
openaire +2 more sources
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source