Results 101 to 110 of about 1,239,580 (286)
Advanced Science, EarlyView.AUTACE is a bifunctional nanoplatform that integrates tumor targeting, immune engagement, and on‐demand KRAS degradation. It targets KRAS/TP53 co‐mutant tumors via TP53‐specific TCRs, elicits antitumor CD8+ T‐cell responses through surface anti‐CD3 antibodies, and uses low‐intensity focused ultrasound (LIFU) to trigger controlled release of the KRAS ...
Luo Li +6 more
wiley +1 more source
Advanced Science, EarlyView.This study identifies GDF15+ TAMs as a cell subset mediating tumor regression after immunotherapy. Macrophage‐intrinsic GDF15 enhances phagocytosis and antigen cross‐presentation to CD8+ T cells through the NF‐κB signaling pathway, thereby inhibiting tumor progression.
Xinyu Zhou +9 more
wiley +1 more source
The Beliana Encyclopedia: a comprehensive Slovak encyclopedia
Entsyklopedychnyi visnyk Ukrainy [The Encyclopedia Herald of Ukraine]Author informs about the large Slovak encyclopedia “Beliana”. It is noted that of the planned over 20 volumes, only nine have been published so far. The significant contribution of Ukrainians, particularly Mykola Mushynka, in preparing encyclopedia articles dedicated to Ukrainian topics is highlighted.
openaire +2 more sources
Advanced Science, EarlyView.This study identifies palmitoylation as a novel regulatory modification of SMAD4, mediated by ZDHHC22/APT2. It activates fatty acid synthesis, creating a self‐reinforcing SMAD4–FASN–palmitate feedback loop that drives pancreatic cancer growth and enhances radiotherapy sensitivity.
Yang Wang +16 more
wiley +1 more source
Development of encyclopedia based on local vegetables North Kayong Regency as biology learning media
JPBI (Jurnal Pendidikan Biologi Indonesia)The people of North Kayong Regency-West Kalimantan still uphold the culture of utilizing plants as food, known as North Kayong local vegetables. Preserving knowledge about existing local potential and its utilization can be done through education based ...
Saripa Aini +2 more
doaj +1 more source
G3BP1 Succinylation at K413 is Critical for Cardiac Function by Modulating PI3K‐AKT‐mTOR Signal Axis
Advanced Science, EarlyView.Schematic illustrating the impact of G3BP1 succinylation at K413 on cardiac function. In the healthy human heart, G3BP1 succinylation maintains homeostatic mTOR signaling. In patients with dilated cardiomyopathy (DCM) and heart failure (HF), G3BP1 de‐succinylation induces RagA expression and disrupts the binding of the TSC1/2 complex, leading to the ...
Yuan Zhang +9 more
wiley +1 more source
The Criterion of Incorporeal and Material Things in the Philosophy of Plotinus and Mūllā Sadrā
Metaphysics, 2010 Incorporeal being consists of immaterial things such as intellect and soul. Also The One, in Plotinus' philosophy, and Independent and Rich Existence (Necessary Being), in Mullā Sadrā's philosophy, are incorporeal and immaterial.
R Akbarian, T Karami
doaj
Advanced Science, EarlyView.The study identifies a NIPAL1‐driven metabolic‐epigenetic circuit in esophageal squamous cell carcinoma that promotes glycolysis, lactate accumulation, and H3K18 histone lactylation, forming a self‐sustaining loop that suppresses CD8+ T cell immunity.
Ri‐Xin Chen +15 more
wiley +1 more source
Advanced Science, EarlyView.This work establishes that ac4C modification on lncRNA Gm26917 governs its spatial interactions with Rpl10 mRNA, and RBP EEF1A1 mediates the interaction between Gm26917 and Rpl10. It elucidates a novel ac4C‐Gm26917‐EEF1A1‐Rpl10 axis in FGSC maintenance both in vitro and in vivo, and provides a potential molecular target for modulating germ cell ...
Xinyue Li, Xiaopeng Hu, Ji Wu
wiley +1 more source