Results 271 to 280 of about 1,225,935 (368)

The impact of aging on achilles tendon ossification in mice. [PDF]

BMC Musculoskelet Disord
Cai H, Lan Y, Liu H, Hao Q.
europepmc   +1 more source

Hexokinase‐2 as a Therapeutic Target: Alleviating Herpes Simplex Keratitis Through Metabolic Reprogramming

Advanced Science, EarlyView.
Herpes Simplex Virus Type 1 (HSV‐1) infection triggers metabolic reprogramming in corneal cells, shifting from mitochondrial respiration to aerobic glycolysis with marked upregulation of Hexokinase‐2 (HK2). This study identifies HK2 as a therapeutic target: inhibiting HK2 with lonidamine significantly reduces viral replication and promotes corneal ...
Dan Jiang, Yining Sun, Xintong Yu, Ruoqi Wang, Yuting Zhang, Jinjie Yu, Shuang Xie, Yujia Cai, Yuhong Luo, Wei Chen   +9 more
wiley   +1 more source

Immune inflammatory regulation in Anti-NMDAR encephalitis: insights from transcriptome analysis. [PDF]

Front Neurol
Qiao S, Wang J, Zhang SC, Wang AH, Li HY, Xin T.   +5 more
europepmc   +1 more source

Sustained‐Release Photothermal Microneedles for Postoperative Incisional Analgesia and Wound Healing via Hydrogen Therapy

Advanced Science, EarlyView.
This study introduces a novel transdermal delivery system of molecular hydrogen for postoperative pain relief and wound healing. This system utilizes sustained‐release photothermal microneedles to integrate hydrogen‐releasing nanoparticles and temperature‐responsive microspheres, achieving acid‐responsive hydrogen release and controlled drug release ...
Aining Zhang, Xue Jiang, Bingrui Xiong, Jiayi Chen, Xin Liu, Siyuan Wang, Bofu Li, Mian Peng, Wei Li   +8 more
wiley   +1 more source

Single-cell transcriptomic landscape indicates the potential role of immunotherapy in metastatic pancreatic angiosarcoma. [PDF]

Gastroenterol Rep (Oxf)
Yang Y, Chen L, Liu M, Lin X, Peng S, Xie Y, Zeng Z, Chen M, Zhang N.   +8 more
europepmc   +1 more source

Neutrophil Mobilization Triggers Microglial Functional Change to Exacerbate Cerebral Ischemia‐Reperfusion Injury

Advanced Science, EarlyView.
These study underscores the pivotal role of neutrophil‐derived myeloid‐related protein 14 (MRP14) in the pathophysiology of acute ischemic stroke (AIS). MRP14 not only disrupts mitochondrial function, thereby inhibiting microglial phagocytosis of neutrophils, but also activates microglial pyroptosis, exacerbating neuroinflammation following AIS ...
Huijuan Jin, Zhifang Li, Senwei Tan, Qinghui Xiao, Qingcan Li, Jiao Ye, Yifan Zhou, Yan Wan, Qiang Liu, Bijoy K Menon, Bo Hu   +10 more
wiley   +1 more source

Platelet-rich fibrin-conditioned medium promotes osteogenesis of dental pulp stem cells through TGF-β and PDGF signaling. [PDF]

Regen Ther
Fujii Y, Yoshida T, Sato A, Ikehata M, Hatori A, Chikazu D, Ghanaati S, Kawase-Koga Y.   +7 more
europepmc   +1 more source

ENCYCLOPEDIA OF AHİLİK AKHILIK

, 2018
openaire   +27 more sources

PlantGPT: An Arabidopsis‐Based Intelligent Agent that Answers Questions about Plant Functional Genomics

Advanced Science, EarlyView.
PlantGPT integrates 60 000+ plant research articles with Arabidopsis phenotype‐gene data through retrieval‐augmented generation and fine‐tuning of Llama3‐8B. This open‐source, specialized AI system outperforms general large language models in plant gene‐phenotype relationships, establishing a new paradigm for functional genomics research and molecular ...
Ruixiang Zhang, Yu Wang, Weiyang Yang, Jun Wen, Weizhi Liu, Shipeng Zhi, Guangzhou Li, Nan Chai, Jiaqi Huang, Yongyao Xie, Xianrong Xie, Letian Chen, Miao Gu, Yao‐Guang Liu, Qinlong Zhu   +14 more
wiley   +1 more source

Proteomic profiling of small extracellular vesicles from bovine nucleus pulposus cells. [PDF]

PLoS One
Samanta A, Yoo MJ, Koh J, Lufkin SC, Lufkin T, Kraus P.   +5 more
europepmc   +1 more source