Results 21 to 30 of about 178,306 (264)
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis
Molecular Oncology, EarlyView.This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht +3 more
wiley +1 more source
Историко-географический журнал, 2022 The article is devoted to the hydrographic conditions of the Crimean Peninsula as part of the Taurida province in the context of the state of its water resources and practices of their use. A historical survey of the Crimea’s hydrological studies and the
E. S. Grishin
doaj +1 more source
The place of encyclopedias and encyclopedia studies in society [PDF]
Proceedings of the Third International Conference on Ukrainian Encyclopedia Studies (Kyiv, October 22-23, 2013). Kyiv: The NASU Institute of Encyclopedic Research, 2014, 2014 In contemporary society, encyclopedias play an important role, being one of the symbols of statehood and an indicator of the level of development of science and culture. The article substantiates the transformation of the role of the encyclopedia in the life of society in different historical eras, and defines the development of encyclopedia studies as
openaire +1 more source
MagmaFlow: A desktop platform for artificial intelligence‐driven expression analysis
FEBS Open Bio, EarlyView.MagmaFlow is a free, no‐code platform for gene expression analysis. It generates interactive volcano plots, links genes to literature, pathways, and diseases, prioritizes candidates using millions of publications, identifies affected biological processes, builds network diagrams, and exports publication‐ready figures and reports for macOS and Windows ...
Carlos E. Buss +7 more
wiley +1 more source
The Woodenest. Stadium by ZHA in the South-West of England
Проект Байкал, 2017 The Forest Green Rovers Stadium (Stroud, UK) designed by Zaha Hadid Architects will be built almost entirely of wood – the first time that will have been done anywhere in the world. The use of wood will ensure reduction of carbon dioxide emissions. Being
Nina Frolova
doaj +1 more source
Accurate and noninvasive prostate cancer detection using plasma‐derived extracellular vesicle RNA
FEBS Open Bio, EarlyView.Plasma extracellular vesicles were captured with WGA‐conjugated magnetic beads and profiled for RNA biomarkers. A three‐RNA panel (NM_024955, NR_047469, and NR_002564) distinguished prostate cancer from healthy controls and benign prostatic hyperplasia, supporting a simple, noninvasive approach to improve prostate cancer detection.
Hanping Wei, Haoran Wu, Wei Feng
wiley +1 more source
A minimal cellulosome‐like system in Cellulosilyticum lentocellum
FEBS Open Bio, EarlyView.Cellulose‐degrading bacteria typically use cellulosomes, large multi‐enzyme complexes on a scaffold protein. In Cellulosilyticum lentocellum, we characterise a far smaller arrangement, a single scaffold bound to one cellulase through a single cohesin‐dockerin interaction.
John Allan +2 more
wiley +1 more source
Uncovering G Protein‐Coupled Receptors: Novel Targets and Biomarkers for Predicting Glioma Prognosis
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Background Low‐grade gliomas (LGG) exhibit significant heterogeneity and recurrence risk. G protein‐coupled receptors (GPCR) contribute to glioma malignant progression, but their prognostic value remains unclear. This work attempts to formulate a GPCR‐based outcome‐predicting model for LGG. Methods Based on TCGA LGG data, the enrichment scores
Jun Yang +4 more
wiley +1 more source
Mediterranean Region Encyclopedia
Проблемы постсоветского пространства, 2021 The Mediterranean Sea consisting of numerous seas is enclosed by three continents — Europe, Asia and Africa. It is a specific phenomenon in terms of geography, oceanology and world history.
A. V. Semenov, I. S. Zonn
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