Results 81 to 90 of about 20,780 (304)
Targeting the PDK1/c‐Myc/SOX10 Signaling in Oligodendrocytes Alleviates Neuropathic Pain
Advanced Science, EarlyView.This work reveals that oligodendrocyte homeostasis, mediated by PDK1, is a critical determinant of neuropathic pain (NPP) pathogenesis. Disruption of PDK1 in oligodendrocytes impairs SOX10‐dependent myelination programs through c‐Myc accumulation, leading to disrupted myelination and the pathophysiology of NPP.
Pingping Qiao +7 more
wiley +1 more source
Advanced Science, EarlyView.ABSTRACT Inflammatory bowel disease (IBD) is characterized by dysregulated T cell responses. RNA helicases, including DExD‐box helicase 21 (DDX21), are pivotal in RNA metabolism, but their role in T cell‐mediated pathology during IBD remains unclear. Here, we demonstrate that DDX21 expression in CD4+ T cells correlates with cell cycle and translation ...
Yujuan Zhang +11 more
wiley +1 more source
Image Transmission and Selenium: Adriano de Paiva and Initial Steps in the XIX Century
EncyclopediaSound transmission, in the form of the telephone, was invented by Alexander Graham Bell et al. in the seventies of the XIX century. Inspired by this development, Adriano de Paiva published in 1878 the idea of the transmission of images at a distance ...
Paulo M. S. T. de Castro
doaj +1 more source
War in the period of caliphs [PDF]
تاریخ اسلام, 2004 Claude Caen, the writer of this part of comprehensive "War" entry in the "Encyclopedia of Islam" - other parts of which are dedicated to war in Iran, Ottoman Empire, India, and Egypt in the Mamluk period and which are complemented with a large number of ...
Cl. Cahen, Ebrahim Mussapoor
doaj
Advanced Science, EarlyView.Neuronal PKM2‐driven glycolysis generates excess lactate that triggers histone H3K18 lactylation (H3K18la), establishing a pathogenic metabolic‐epigenetic axis in epilepsy. Elevated H3K18la enriches the Cop1 promoter, transcriptionally upregulating the E3 ubiquitin ligase COP1, which subsequently drives proteasomal degradation of GABAARβ2 and impairs ...
Yuan Meng +8 more
wiley +1 more source
Descriptive linguistics: (Encyclopedia entry.)
, 2013 International audienceEntry "Descriptive linguistics" of the encyclopedia Theory in social and cultural ...
Ponsonnet, Maïa
core +1 more source
Computing Machines: Entry for the Second Edition of the Encyclopedia of Philsophy
, 2018 Wilfred Sieg and Rosella Lupiccini.
Wilfried Sieg (5372201) +1 more
core +1 more source
Self‐Assembling Hybrid Hydrogel Reprograms the Stromal Vascular Fraction to Treat Osteoarthritis
Advanced Science, EarlyView.This study presents a bioinspired injectable hydrogel that enhances the therapeutic potential of stem cell‐rich stromal vascular fraction for treating osteoarthritis. By reprogramming cell behavior through epigenetic modulation, the hydrogel promotes cartilage regeneration and reduces joint damage in a rat model, offering a promising new approach for ...
Waifang Hou +23 more
wiley +1 more source