Results 41 to 50 of about 78,649 (333)
Constitutivism without Normative Thresholds [PDF]
, 2017 Constitutivist accounts in metaethics explain the normative standards in a domain by appealing to the constitutive features of its members. The success of these accounts turns on whether they can explain the connection between normative standards and the
Lindeman, Kathryn
core +2 more sources
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Fifteenth century earth science [PDF]
, 1967 The earth science content of two late medieval encyclopedias, the Mirrour of the World and Higden's Polychronicon, both printed by William Caxton in the 1480's, is examined in relation to fifteenth century ideas about the physical nature of the earth and
Stokes, Evelyn
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Molecular Oncology, EarlyView.Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad +12 more
wiley +1 more source
What Future for Traditional Encyclopedias in the Age of Wikipedia?
Culture Unbound: Journal of Current Cultural Research, 2014 The launch and rapid domination of Wikipedia as a reference tool for the Internet was as dramatic as it was unexpected. Wikipedia broke so many of the rules of reference publishing, which, even if not formally codified, had been widely accepted for many ...
Michael Upshall
doaj
Book review: Psychology and politics: a social identity perspective [PDF]
, 2013 "Psychology and Politics: a Social Identity Perspective." Alexa Ispas. Psychology Press. December 2012. --- This book covers a wide range of political topics, such as the way in which categorising ourselves into groups influences how we perceive the ...
Laberge, Yves
core
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Loading Chekhov’s Gun in 9-Times: The Fundamental Disconnect in Historical Interpretation [PDF]
, 2013 Thursday night brings into Gettysburg an avalanche of historians (both public and academic) to discuss the Future of Civil War History for a whole weekend.
Rudy, John M.
core +1 more source
Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition
Molecular Oncology, EarlyView.We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li +10 more
wiley +1 more source
Electronic Encyclopedias: Concepts, Advantages and Disadvantages [PDF]
تحقیقات اطلاعرسانی و کتابخانههای عمومی, 2010 Purpose: Electronic encyclopedia is a novel phenomenon emerged in information system. This study aims to study the concepts, advantages, and disadvantages of electronic encyclopedias.
Masoud Rezaei
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