Results 111 to 120 of about 768,450 (337)

β‐Catenin/c‐Myc Axis Modulates Autophagy Response to Different Ammonia Concentrations

Advanced Biology, Volume 9, Issue 3, March 2025.
Ammonia, detoxified by the liver into urea and glutamine, impacts autophagy differently at varying levels. Low ammonia activates autophagy via c‐Myc and β‐catenin, while high levels suppress it. Using Huh7 cells and Spf‐ash mice, c‐Myc's role in cytoprotective autophagy is revealed, offering insights into hyperammonemia and potential therapeutic ...
S. Sergio, B. Spedicato, G. Corallo, A. Inguscio, M. Greco, D. Musarò, D. Vergara, A. F. Muro, G. De Sabbata, L. R. Soria, N. Brunetti Pierri, M. Maffia   +11 more
wiley   +1 more source

Recovery of renal function after long-term dialysis in hemolytic uremic syndrome [PDF]

, 2018
Long-lasting recovery of renal function of the native kidneys after prolonged renal replacement therapy is rare. An 8-year-old girl and a 3-year-old boy had suffered from acute atypical and diarrhea-associated hemolytic uremic syndrome (HUS ...
Bianchetti, Mario, Brunner, Kathrin, Neuhaus, Thomas   +2 more
core  

Revisiting copper and zinc in end-stage renal disease patients

Pediatria Polska
Numerous research projects have discovered how trace elements affect people with end-stage renal disease (ESRD). Thus, understanding the mechanism of action and the potential treatment options requires research into the chemical compounds that have an ...
Maha Abd Sahab, Basim Abd Al-Raheem, Khalid Farouk, Hussein Al-Hakeim, Maha Abd Al-Sahab   +4 more
doaj   +1 more source

Adipose Mesenchymal Stem Cell‐Derived Exosomes in Conjunction with Roflumilast Ameliorate Chronic Kidney Disease Through the Modulation of Fibrosis and Inflammation

Advanced Biology, EarlyView.
The novelty of this study showed that the injection of exosomes produced from ADMSCs in combination with Roflumilast poses a more favorable therapeutic outcome for CKD induced by Adriamycin, compared to therapy with exosomes or Roflumilast alone. Roflumilast and exosomes treatment lowered the expression of the apoptotic, fibrotic, and inflammatory ...
Mohamed Ali, Mohamed H. Sherif, Nashwa Barakat, Bassant Yahia, Ahmed A. Shokeir, Basel Sitohy   +5 more
wiley   +1 more source

Proceedings From the Symposium on Kidney Disease in Older People: Royal Society of Medicine, London, January 19, 2017 [PDF]

, 2017
People are living longer. On the whole, they have healthier lives and many of the problems previously seen at a younger age now appear in their later years. Kidneys, like other organs, age, and kidney disease in the aged is a prime example. In the United
Abdulla, Aza, Bartholomew, Carol, Brown, Edwina A, Gallagher, Hugh, Iyasere, Osasuyi, Lowton, Karen, Ma, Nan, Ross, Louise E, Wright, Pandora N   +8 more
core   +2 more sources

Compliance of End Stage Renal Disease Patients on Haemodialysis

Journal of Rawalpindi Medical College, 2011
Background: To find out the factors which are responsible for non-compliance, even with free dialysis facilities. Methods: In this prospective study the patients with renal failure who were on maintenance dialysis were studied .
Mohammad Nadeem
doaj  

Varicella infections in patients with end stage renal disease: a systematic review

BMC Nephrology, 2018
Background End stage renal disease (ESRD) is on the rise globally. Varicella infection among adult patients with ESRD has been reported to lead to multiple complications and even death. While varicella vaccination has been recommended in paediatric renal
Chong Yau Ong, Sher Guan Low, Farhad Fakhrudin Vasanwala, Shashidhar Baikunje, Lian Leng Low   +4 more
doaj   +1 more source

Adalimumab‐Poloxamer Conjugate for Bio‐Better: Enhanced Stability and Function

Advanced Functional Materials, EarlyView.
Antibody‐polymer conjugates, particularly poloxamer conjugates, enhance antibody stability by improving tolerance to physicochemical stress and attenuating proteolysis by proteases. Furthermore, the higher affinity observed with poloxamer conjugation compared to standard PEGylation results in improved therapeutic efficacy in rheumatoid arthritis mouse ...
Jaewon Roh, Sanghee Lee, Soomin Cho, Kun Na   +3 more
wiley   +1 more source

Impact of end stage kidney disease on costs and outcomes of Clostridium difficile infection

International Journal of Infectious Diseases, 2017
Objectives: To assess the impact of end stage kidney disease (ESKD) on the outcomes of Clostridium difficile infection (CDI), including complications of infection, length of hospital stay, overall mortality, and healthcare burden.
Abhinav Goyal, Kshitij Chatterjee, Sujani Yadlapati, Janani Rangaswami   +3 more
doaj   +1 more source

Endocytic Programming via Porous Silicon Nanoparticles Enhances TLR4 Nanoagonist Potency for Macrophage‐Mediated Immunotherapy

Advanced Functional Materials, EarlyView.
Porous silicon nanoparticles (PSiNPs) reprogram macrophage endocytosis of manganese@albumin‐based TLR4 nanoagonists, driving TRIF‐biased TLR4 signaling, eliciting robust proinflammatory responses, and potentiating macrophage‐mediated immunotherapeutic effects against NSCLC.
Xiaomei Zhang, Huiying Li, Shuodan Huang, Linxuan Zhang, Yan Gao, Ruoran Wang, Xiaoyu Wang, Hélder A. Santos, Zhenyu Yin, Bing Xia   +9 more
wiley   +1 more source