Comparative risk of end-stage renal disease, myocardial infarction and stroke in young and older onset diabetes in UK Biobank. [PDF]
Kar D +17 more
europepmc +1 more source
Targeted Expansion of Treg Cells to Induce Immune Tolerance after Kidney Transplantation
A dual‐targeting nanoparticle platform that selectively engages graft stromal cells via CD248 receptors while employing kidney‐ specific promoters (NPHS2) to drive localized IL‐ 2/TGF‐βexpression is developed. This approach achieves three therapeutic objectives:1) intragraft Treg polarization without systemic cytokine exposure;2) reduced dependence on ...
Tong Lu +18 more
wiley +1 more source
Correlation analysis of anxiety, depression, and sleep quality in end-stage renal disease patients undergoing maintenance hemodialysis. [PDF]
Du Z, Chu T, Dai F, Mao H, Zhao J.
europepmc +1 more source
Targeting Histamine H4 Receptor in the Rostral Ventromedial Medulla to Relieve Hypertension
H4R and its downstream TRPV1 channel mediate the excitatory effect of TMN histaminergic afferent inputs on GABAergic sympathoinhibitory neurons in RVMM. Intranasal delivery of selective H4R agonist VUF 8430 suppresses renal sympathetic outflow and elicits sustained depressor and bradycardia responses in SHRs and CUMS‐induced hypertensive rats ...
Ying Shi +18 more
wiley +1 more source
Whole-exome sequencing of kidney transplant recipients and donors: insights into end-stage renal disease and post-transplant genetic risk. [PDF]
Bayanova M +15 more
europepmc +1 more source
This study explores the therapeutic potential of iNSC‐Exo via local and systemic delivery in TBI mice. It is found that iNSC‐Exo enhances NRXN signaling through Microglia_Nrg3 and Microglia_Rarb, effectively promoting functional and neurological recovery, suggesting a new therapeutic strategy for TBI. Abstract Traumatic brain injury (TBI) poses serious
Jiaojiao Li +9 more
wiley +1 more source
Malnutrition among patients with end-stage renal disease in war 2024: the role of healthcare access, dialysis, gender, and economic disparities. [PDF]
Elhassan S +6 more
europepmc +1 more source
Lipid Lowering in End-Stage Renal Disease
Wanner Christoph +2 more
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