Results 41 to 50 of about 589,938 (329)

Emerging role of ARHGAP29 in melanoma cell phenotype switching

Molecular Oncology, EarlyView.
This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster, Melanie Kappelmann‐Fenzl, Anja Katrin Bosserhoff, Nicole Rachinger   +3 more
wiley   +1 more source

Gut microbiota diversity is prognostic in metastatic hormone receptor‐positive breast cancer patients receiving chemotherapy and immunotherapy

Molecular Oncology, EarlyView.
In this exploratory study, we investigated the relationship between the gut microbiota and outcome in patients with metastatic hormone receptor‐positive breast cancer, treated in a randomized clinical trial with chemotherapy alone or chemotherapy in combination with immune checkpoint blockade.
Andreas Ullern, Kristian Holm, Nikolai Kragøe Andresen, Andreas Hagen Røssevold, Corinna Bang, Bjørn Naume, Johannes R. Hov, Jon Amund Kyte   +7 more
wiley   +1 more source

Exercise training in pediatric patients with end-stage renal disease [PDF]

, 2008
The objective of this study was to determine the feasibility and efficacy of an exercise training program to improve exercise capacity and fatigue level in pediatric patients with end-stage renal disease (ESRD).
ATS Committee on Proficiency Standards for Clinical Pulmonary Function Laboratories, DJ Weaver Jr., EA Beenakker, J Vercoulen, Jaap Groothoff, Jeroen Nauta, KL Johansen, Koen van Hoeck, M Van Brussel, Marc Lilien, Monique van Bergen, N Wulffraat, O Verschuren, P Edouard, P Painter, Paul Helders, Raoul Engelbert, RH Engelbert, RM Eijsermans, S Molsted, Tim Takken   +20 more
core   +7 more sources

Renal replacement modality and stroke risk in end-stage renal disease—a national registry study [PDF]

, 2017
Background: The risk of stroke in end-stage renal disease (ESRD) on renal replacement therapy (RRT) is up to 10-fold greater than the general population. However, whether this increased risk differs by RRT modality is unclear.
Dawson, Jesse, Findlay, Mark, MacIsaac, Rachael, MacLeod, Mary Joan, Mark, Patrick B., Metcalfe, Wendy, Traynor, Jamie P.   +6 more
core   +1 more source

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

Magnitude of the Difference Between Clinic and Ambulatory Blood Pressures and Risk of Adverse Outcomes in Patients With Chronic Kidney Disease. [PDF]

, 2019
Background Obtaining 24-hour ambulatory blood pressure ( BP ) is recommended for the detection of masked or white-coat hypertension. Our objective was to determine whether the magnitude of the difference between ambulatory and clinic BP s has prognostic ...
Bae, Se Ri, Grimes, Barbara A, Hsu, Raymond K, Ku, Elaine, Lipkowitz, Michael S, Smogorzewski, Miroslaw J, Tuot, Delphine S, Weir, Matthew R   +7 more
core   +1 more source

Glutathione transferase gene polymorphism in end stage renal disease [PDF]

Medicinski Podmladak, 2016
Chronic kidney disease is described as a progressive and irreversible deterioration in kidney function. When there is less than 10% of nephron function pertained, patients face end-stage renal disease, where renal replacement therapy is needed. Data show
Šuvakov Sonja, Simić Tatjana, Damjanovic Tatjana   +2 more
doaj   +1 more source

The prognostic importance of chronic end-stage diseases in geriatric patients admitted to 163 Italian ICUs [PDF]

, 2017
BACKGROUND: The number of elderly patients undergoing major surgical interventions and then needing admission to intensive care unit (ICU) grows steadily.
Alampi, Daniela, Bertolini, G., DE BLASI, Roberto Alberto, Finazzi, S., Giviti,, Gristina, G., Livigni, S., Malacarne, P., Mannoni, R., Nattino, G., Poole, D., Radrizzani, D., Sorgato, C   +12 more
core   +1 more source

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source

Is psoriasis an independent risk factor of renal disease? A nationwide retrospective cohort study from 1996 to 2010

Dermatologica Sinica, 2017
Background: Psoriasis is a chronic inflammatory disease that affects the skin, joints, and cardiovascular system. Although a potential association of end-stage renal disease (ESRD) with psoriasis has been demonstrated in patients, the potential for the ...
Sebastian Yu, Hung-Pin Tu, Chu-Ling Yu, Chih-Hung Lee, Chien-Hui Hong   +4 more
doaj   +1 more source