Results 101 to 110 of about 4,456,043 (294)

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

The conformation of conducting polymer chains: Hubbard polymers

, 1994
The conformational and electronic properties of conducting flexible random and self-avoiding walk polymer chains are under investigation. A Hamiltonian for conjugated flexible polymers is introduced and its physical consequences are presented.
de Gennes, de Gennes, Doi, Efetov, Fesser, Harigaya, Harrah, Lim, M. Otto, Mizes, Otto, Parisi, Pincus, Schweizer, Schweizer, Shimada, Su, Su, T.A. Vilgis, Wegner   +19 more
core   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Tangentially active polymers in cylindrical channels

SciPost Physics
We present an analytical and computational study characterizing the structural and dynamical properties of an active filament confined in cylindrical channels. We first outline the effects of the interplay between confinement and polar self-propulsion on
José Martín-Roca, Emanuele Locatelli, Valentino Bianco, Paolo Malgaretti, Chantal Valeriani
doaj   +1 more source

Scaling behavior of self-avoiding walks on percolation clusters

, 2008
The scaling behavior of self-avoiding walks (SAWs) on the backbone of percolation clusters in two, three and four dimensions is studied by Monte Carlo simulations. We apply the pruned-enriched Rosenbluth chain-growth method (PERM).
Barat K., de Gennes P.-G., des Cloizeaux J., Grassberger P., Grassberger P., Grassberger P., Guida R., Havlin S., Herrmann H. J., Herrmann H. J., Hoshen J., Kim Y., Kim Y., Lam P. M., Lee S. B., Mac Donald D., MacDonald D., Nakanishi H., Reis F., Sahimi M., Stauffer D., V. Blavatska, W. Janke   +22 more
core   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Effect of confinement on coil-globule transition

, 2004
The equilibrium thermodynamic properties of a linear polymer chain confined to a space between two impenetrable walls (lines) at a distance $D$ under various solvent conditions have been studied using series analysis and exact enumeration technique.
Arceta, Arceta, Arteca, Barr, Binder, Birshtein, Burkhardt, Daoud, De Joannis, Eisenriegler, Finsy, Fleer, Foster, Foster, Grassberger, Grassberger, Grassberger, Grassberger, Ishinabe, Kremer, Lax, Metzger, Milchev, Milchev, Mishra, Mishra, P. K. Mishra, Rajesh, Sanjay Kumar, Singh, Singh, van Giessen, van Vliet, Wall, Wall, Wall, Webman   +36 more
core   +1 more source

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

Molecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann, Eduardo García‐Galea, Alice O'Farrell, Zak Kinsella, Maxime Meylan, Florent Petitprez, Ingrid Arijs, Tom Venken, Hari Ps, Adrian Lärkeryd, Ian Miller, Janick Selves, Nadja Meindl‐Beinker, Fiorella Ruiz‐Pace, Elena Élez, Raquel Comas‐Navarro, Frank Lincoln, Dirk Fey, Gift Nyamundanda, Aoife Nolan, Joern Lewin, Raquel Perez‐Lopez, Jonathan Briody, Kathleen Bennett, Walter Kolch, David Matallanas, Alexander Kel, Enrique Arenas, Joaquín Arribas, Bart Ghesquière, Josep Tabernero, Julie Meilleroux, Deborah McNamara, Ray McDermott, Marvin Lim, Mary O'Reilly, Brian Bird, Lisa Stack, Lucia Moloney, Patrick Morris, Keith Egan, Maciej Milewski, Lars Scheuer, Joachim Behringer, Georg Bolz, Ramon Salazar, Cristina Santos, Andrea Ruiz, Orla Casey, Verena Murphy, Matthias Ebert, Livio Trusolino, Diether Lambrechts, Anguraj Sadanandam, Catherine Sautès‐Fridman, Jochen Prehn, Paolo Nuciforo, Jacques Fieschi, Florence Monville, Darran O'Connor, Wolf Fridman, Annette Byrne   +61 more
wiley   +1 more source

End-to-end Security with Translation [PDF]

Journal of Systemics, Cybernetics and Informatics, 2017
End-to-end security involves two entities communicating at a distance over an insecure communication channel while maintaining many of the security properties of private, in-person communication.
Kevin E. Foltz
doaj  

Scaling and Scale Breaking in Polyelectrolyte

, 1996
We consider the thermodynamics of a uniformly charged polyelectrolyte with harmonic bonds. For such a system there is at high temperatures an approximate scaling of global properties like the end-to-end distance and the interaction energy with the chain ...
Bo Söderberg, Carsten Peterson, Ola Sommelius, Stevens M. J.   +3 more
core   +2 more sources