Results 61 to 70 of about 280,629 (216)
Care at the end of life: how policy and the law support practice [PDF]
, 2013 The End of Life Care Strategy was introduced in an attempt to achieve\ud a high standard of care for patients nearing the end of life and to\ud improve carer experience.
Brown, Michelle, Vaughan, Carol
core
Dying from liver disease: the importance of end-of-life discussions [PDF]
, 2018 Over the past 50 years, deaths from liver disease have risen dramatically, whereas deaths from many other major diseases have fallen. Liver disease is now the third largest cause of premature death in the UK, with alcohol-related liver disease accounting
Watson, Sharan, Mortimore, Gerri
core +1 more source
FEBS Letters, EarlyView.The pyruvate generator, which causes activation of respiration by extra‐mitochondrial Ca2+, is also present and functional in rat brainstem mitochondria, as it is in other brain regions. This finding is confirmed by experiments with a fully reconstituted malate–aspartate shuttle (MAS).
Grazyna Debska‐Vielhaber +7 more
wiley +1 more source
The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome
FEBS Letters, EarlyView.This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley +1 more source
End-of-life disposal concepts for libration point and highly elliptical orbit missions [PDF]
, 2014 Libration Point Orbits (LPOs) and Highly Elliptical Orbits (HEOs) are often selected for astrophysics and solar terrestrial missions. No guidelines currently exist for their end-of life, however it is a critical aspect to other spacecraft and on ground ...
F. Letizia +18 more
core +1 more source
FEBS Letters, EarlyView.An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley +1 more source
Ubiquitination of secretory granules promotes their crinophagic degradation in Drosophila
FEBS Letters, EarlyView.Ubiquitination of secretory granules in Drosophila larval salivary glands is a critical molecular trigger for crinophagy, the lysosomal degradation of unreleased, or low‐quality granules. The E3 ubiquitin ligase Cnot4 is recruited to the surface of secretory granules to induce crinophagy.
Tamás Csizmadia +6 more
wiley +1 more source
Practice development in end of life home care [PDF]
, 2015 This keynote presentation for the German Patient Safety in Palliative Home Care Round Table Discussion and Conference at Berlin Charité Medical University (8th -11th April, 2015) outlines the principles of practice development and provides published ...
O'Connor, S.
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Paying for end of life in care homes in the UK
, 2020 To live to a ripe old age, untroubled by health problems, physical or mental, is an almost universal aspiration. But most people are not so lucky and will likely be in care homes for their final years, with varying levels of disease, disability and ...
Stubbs, John, Adetunji, Jacob
core +1 more source