Results 61 to 70 of about 2,190,077 (313)

Social workers’ involvement in advance care planning: a systematic narrative review

BMC Palliative Care, 2017
Background Advance care planning is a process of discussion that enables competent adults to express their wishes about end-of-life care through periods of decisional incapacity.
Chong-Wen Wang, Cecilia L. W. Chan, Amy Y. M. Chow   +2 more
doaj   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

“The great escape”: how an incident of elopement gave rise to trauma informed palliative care for a patient experiencing multiple disadvantage

BMC Palliative Care
Background This case report from Scotland, UK illustrates how unresolved traumatic experiences across the life course can affect a patient’s engagement with palliative care and offers insights into the flexibility and adaptations necessary for taking a ...
Sam Quinn, Libby Ferguson, Derek Read, Naomi Richards   +3 more
doaj   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

When is hastened death considered suicide? A systematically conducted literature review about palliative care professionals’ experiences where assisted dying is legal

BMC Palliative Care, 2019
Background Laws allowing assisted suicide and euthanasia have been implemented in many locations around the world but some individuals suffering with terminal illness receiving palliative care services are hastening death or die by suicide without ...
Sheri Mila Gerson, Amanda Bingley, Nancy Preston, Anne Grinyer   +3 more
doaj   +1 more source

The End of Life, The Ends of Life: An Anthropological View [PDF]

Journal of the Islamic Medical Association of North America, 2012
All known human societies have a worldview that deserves to be called religion; all religions must explain death. Anthropologists study the diversity of religious systems, present and past, in order to understand what is common to humanity. Rather than starting from the view of a particular revelation or set of doctrines, the anthropologist tries to ...
openaire   +2 more sources

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Uncovering the end-of-life trajectories of older people with serious chronic illnesses: study protocol for the quantitative longitudinal study of the TRAJECT project

BMJ Open
Introduction Older people who die with a serious chronic disease are at risk of experiencing extended periods (ie, months or years) of fluctuations and deterioration in their health and well-being.
Lieve Van den Block, Aline De Vleminck, Lara Pivodic, Nele Van Den Noortgate, Eline Naert, Lore Decoster, Casper Van den Bossche, Khyati Tripathi   +7 more
doaj   +1 more source

Enhancing & Mobilizing the POtential for Wellness & Emotional Resilience (EMPOWER) among Surrogate Decision-Makers of ICU Patients: study protocol for a randomized controlled trial

Trials, 2019
Background Critical illness increases the risk for poor mental health outcomes among both patients and their informal caregivers, especially their surrogate decision-makers.
Holly G. Prigerson, Martin Viola, Chris R. Brewin, Christopher Cox, Daniel Ouyang, Madeline Rogers, Cynthia X. Pan, Shayna Rabin, Jiehui Xu, Susan Vaughan, Janna S. Gordon-Elliot, David Berlin, Lindsay Lief, Wendy G. Lichtenthal   +13 more
doaj   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source