Results 171 to 180 of about 315,907 (248)

Single Cell and Spatial Transcriptomics Define a Proinflammatory and Profibrotic Niche After Kidney Injury

Advanced Science, EarlyView.
By integrating single‐cell RNA sequencing and spatial transcriptomics, tenascin C (TNC) is unveiled as a central organizer of the proinflammatory and profibrotic niche in kidney fibrosis. TNC promotes macrophage activation through TLR4/NF‐κB signaling, leading to renal inflammation and fibrosis.
Li Li, Jinlin Liao, Yuxi Zhang, Zifu Yao, Junxin Huang, Kejia Wu, Lu Li, Yiling Peng, Haili Zhu, Xue Hong, Xi Liu, Lili Zhou, Fan Fan Hou, Haiyan Fu, Youhua Liu   +14 more
wiley   +1 more source

TLR4 rs2149356 Polymorphism in Periodontitis and End-Stage Renal Disease: An Exploratory Analysis in Egyptian Patients. [PDF]

Cells
Abou-Bakr A, Hassanein FEA, Nagi N, Ibrahim M, Mekhemar M.   +4 more
europepmc   +1 more source

Indicators for blood glucose control in diabetics with end-stage chronic renal disease: GHb vs. glycated albumin (GA)

, 2006
Keiko Chujo, Kenji Shima, Hiroaki Tada, Teruyo Oohashi, Jun Minakuchi, Syu Kawashima   +5 more
openalex   +2 more sources

HIFU‐Driven Targeted Pyroptosis Therapy in Basal‐Like Breast Cancer

Advanced Science, EarlyView.
This study presents a HIFU‐driven pyroptosis strategy for BLBC treatment. Combining HIFU with platelet‐membrane hybridized liposomes encapsulating mitoxantrone enhances tumor targeting and efficacy. The synergistic treatment modulates key epigenetic regulators and activates the pyroptotic pathway through ROS generation and inflammasome signaling ...
Xiaomin Su, Yang Wang, Xifeng Qin, Yaqiong Xiao, Boshu Ouyang, Lina Hu, Lin Kang, Ruizhe Xu, Ce Xu, Zanya Sun, Chenyu Sun, Huishu Guo, Zhiqing Pang, Shun Shen   +13 more
wiley   +1 more source

A presentation of brown tumor in a patient with parathyroid adenoma and end-stage renal disease: A case report. [PDF]

Medicine (Baltimore)
Gohar A, Ahmad MH, Masroor M, Ali M, Ayman A, Usman A, Riaz Z, Ahmed B.   +7 more
europepmc   +1 more source

Prevalence of Elevated Troponin I in End‐stage Renal Disease Patients Receiving Hemodialysis [PDF]

, 2004
Michael W. Donnino, V Karriem-Norwood, Emanuel P. Rivers, Ajay Gupta, H. Bryant Nguyen, Gordon Jacobsen, James McCord, Michael C. Tomlanovich   +7 more
openalex   +1 more source

Histone Lactylation‐Driven Upregulation of VRK1 Expression Promotes Stemness and Proliferation of Glioma Stem Cells

Advanced Science, EarlyView.
Glioblastoma (GBM) is the most aggressive primary brain tumor, with glioma stem cells (GSCs) driving treatment resistance. This study reveals that lactate promotes histone lactylation (H3K18la) at the VRK1 promoter, regulating GSC stemness and proliferation via the H3K18la/VRK1/YBX1/SOX2 pathway. The VRK1‐targeted nanoliposome A/TMZ‐siVRK1 demonstrates
Jinna Li, Chenyue Tang, Xuefeng Zhang, Rui Xing, Qing Guo   +4 more
wiley   +1 more source

Gastrointestinal disease in end-stage renal disease. [PDF]

World J Nephrol
Khan A, Mushtaq M, Movva G, Sohal A, Yang J.   +4 more
europepmc   +1 more source

GSK461364 Inhibits NLRP3 Inflammasome by Targeting NEK7 Phosphorylation

Advanced Science, EarlyView.
Schematic diagram of the mechanism by which GSK461364 inhibits NLRP3 inflammasome activation. GSK461364 inhibits the phosphorylation of NEK7 likely at serine 221 and serine 260 by suppressing the activity of PLK1, thereby restraining the formation of the NLRP3 inflammasome.
Ruiheng Luo, Mingliang Ma, Dan Wang, Ling Luo, Xueming Xu, Lingmin Huang, Fupeng Wang, Guangyan Kuang, Huiqi Liu, Rui Ni, Xin Li, Qinghua Zhang, Shengfeng Wang, Kai Zhao   +13 more
wiley   +1 more source

Efficacy and safety of sacubitril/valsartan in end-stage renal disease patients with heart failure: a review. [PDF]

Ann Med
Li P, Li Y, Zhang L.
europepmc   +1 more source