Results 191 to 200 of about 315,907 (248)

METTL10‐Mediated PIAS3 Methylation Links Purine Metabolism to Gastric Cancer Progression

Advanced Science, EarlyView.
METTL10‐mediated methylation of PIAS3 at K442 inhibits its SUMO E3 ligase activity toward MITF. This reduces MITF SUMOylation and subsequent RNF4‐mediated ubiquitination, leading to MITF protein accumulation and gastric cancer progression. Abstract Metabolic dysregulation plays a significant role in the development of gastric cancer (GC).
Jinshui Tan, Huiwen Zhou, Jingsong Ma, Chensong Zhang, Yuhua Tan, Baoding Zhang, Jiabao Zhao, Ao Cheng, Chengyu Yang, Meijuan Xu, Shengyi Zhou, Yubo Xiong, Zeyang Lin, Guangchao Pan, Wenjie Ye, Mengya Zhong, Yang Yang, Yifan Zhuang, Shao‐Wei Li, Xianming Deng, Xuehui Hong   +20 more
wiley   +1 more source

Urine Proteomics for Detection of Potential Biomarkers for End-Stage Renal Disease. [PDF]

Int J Mol Sci
Silva NR, Picolo BU, de Sousa LCM, Dos Santos MS, Polveiro RC, Almeida-Souza HO, Martins MM, Goulart Filho LR, da Silva LS.   +8 more
europepmc   +1 more source

RIPK1 Drives JAK1‐STAT3 Signaling to Promote CXCL1‐Mediated Neutrophil Recruitment in Sepsis‐Induced Lung Injury

Advanced Science, EarlyView.
This article examines the central role of RIPK1 in the pathogenesis of sepsis‐induced lung injury. It elucidates how RIPK1 initiates an inflammatory cascade by activating JAK1‐STAT3 signaling, leading to CXCL1‐mediated neutrophil infiltration. Importantly, it demonstrates that pharmacological inhibition of RIPK1 effectively attenuates inflammation and ...
Hao Sun, Xiya Li, Shenjia Gao, Yi Jiang, Xinyi Wu, Zhaoyuan Chen, Han Wu, Qing Hua, Rui Zu, Huaijiang Xiang, Ronen Ben‐Ami, Changhong Miao, Li Tan, Ying Li, Jun Wang, Wankun Chen   +15 more
wiley   +1 more source

Left atrial appendage occlusion in patients with end-stage renal disease: an individual patient-level meta-analysis. [PDF]

Europace
Rodriguez-Riascos JF, Vemulapalli HS, Akin I, Areiza LA, Della Rocca DG, Eitel I, Fink T, Genovesi S, Kefer J, Zweiker D, Prajapati P, Srivathsan K.   +11 more
europepmc   +1 more source

Prevalence of St-Elevation Myocardial Infarction in End Stage Renal Disease Patients Admitted with Acute Coronary Syndrome at Shifa International Hospital Islamabad

Atul Kakar, Fareeha Khalil, Nughman Ali
openalex   +2 more sources

Loss of Hepatic Angiotensinogen Attenuates Diastolic Dysfunction in Heart Failure with Preserved Ejection Fraction

Advanced Science, EarlyView.
Increased hepatic angiotensinogen (AGT) abundance leads to cardiac diastolic dysfunction via the AngII‐independent pathway. Liver‐derived AGT is internalized by LRP2 in cardiac endothelial cells, subsequently contributing to myocardial diastolic dysfunction by suppressing microvascular angiogenesis via inhibiting the GATA2/Pim3 pathway.
Zetao Heng, Min Hong, Zhaocai Zhang, Ximing Ye, Jianan Zhou, Wentao Wu, Jiabing Rong, Yinchuan Xu   +7 more
wiley   +1 more source

Latent Profiles of Advance Care Planning Engagement and Death Attitudes in Dialysis Patients with End-Stage Renal Disease. [PDF]

J Multidiscip Healthc
Cheng S, Shu P, Chen J, Wang X, Lv Y, Xu F.   +5 more
europepmc   +1 more source

CDH1 Orchestrates Anabolic Events to Promote Cell Cycle Initiation

Advanced Science, EarlyView.
Cell proliferation requires the integration of cell cycle and anabolic signals. G1‐phase regulator CDH1 coordinates anabolism through the CDH1‐VHL‐AARS2/HIF1α axis, while CDH1‐accumulated R5P is sensed by TKTL1 to facilitate CDH1 degradation and cell cycle initiation, constituting a CDH1‐centered regulatory circuit.
Yun‐Zi Mao, Jiao‐Jiao Zhang, Meng‐Qi You, Han Wang, Yan Lin, Yuan Fang, Hui‐Lu Zhang, Yuan‐Yuan Qu, Qian Zhou, Meng Wang, Gang Li, Zi‐Fan Guo, Meng Xu, Jie Liu, Peng‐Cheng Lin, Yi‐Yuan Yuan, Yu Kang, Shi‐Min Zhao, Wei Xu   +18 more
wiley   +1 more source

Preclinical approaches in regenerative medicine for treating end-stage renal disease: a scoping review. [PDF]

Front Endocrinol (Lausanne)
Vigezzi A, Brani P, Dalla Gasperina D, Azzi L, Giaroni C, Inversini D, Pettinato G, Massaad M, Carcano G, Ietto G, Baj A.   +10 more
europepmc   +1 more source

Impact of Work Status on Quality of Life in Patients with End-stage Renal Disease During the First Year of Hemodialysis [PDF]

Saule Bodessova, Н.С. Сагандыкова, Kurmet Danebek, B. Sultanova, Мадина Бауржан   +4 more
openalex   +1 more source