Results 41 to 50 of about 35,833 (177)

Salvianolic Acid a Disrupts the HSP90α‐AKT‐PERK Ternary Complex to Alleviate Atherosclerosis by Activating Endoplasmic Reticulum Stress of Senescent Vascular Smooth Muscle Cells

Advanced Science, EarlyView.
Salvianolic acid A (SAA) selectively induces senescent vascular smooth muscle cell apoptosis, alleviating atherosclerosis. Mechanistically, SAA targets heat shock protein 90 alpha (HSP90α) to disrupt the protein inase B (AKT)‐PRKR‐Like Endoplasmic Reticulum Kinase (PERK) scaffold, driving ubiquitin‐proteasome‐dependent AKT degradation.
Xiuya Guan, Mengkai Lu, Xinhai Cui, Dawei Zhang, Lei Zhang, Lin Lin, Yuan Li, Yuanlong Hu, Chao Li   +8 more
wiley   +1 more source

Comparison of Long Term Prognosis between Carotid Endarterectomy versus Stenting; A Korean Population-Based Study Using National Insurance Data [PDF]

Neurointervention, 2019
Purpose Although carotid endarterectomy (CEA) is recommended as a treatment for carotid stenosis rather than carotid artery stenting (CAS), CAS has been preferred in Korea.
Kwon-Duk Seo, Kyung-Yul Lee, Sang Hyun Suh   +2 more
doaj   +1 more source

A critical reappraisal of the carotid sinus and carotid bulb: Distinguishing neurohistological function from vascular geometry

The Anatomical Record, EarlyView.
This review redefines the carotid bulb (CB) as a variable geometric dilation shaped by hemodynamics and the carotid sinus (CS) as a conserved neurohistological baroreceptor field. Distinguishing these entities clarifies a century of anatomical confusion and links geometry, neurohistology, and clinical interpretation within a unified framework ...
Răzvan Costin Tudose, Nicolae Radu, Mugurel Constantin Rusu   +2 more
wiley   +1 more source

Red Blood Cell Distribution Width as a 5-Year Prognostic Marker in Patients Submitted to Carotid Endarterectomy

Cerebrovascular Diseases Extra, 2020
Objective: Patients submitted to carotid artery endarterectomy (CEA) have a long-term risk of major adverse cardiovascular events (MACE) of 6–9% at 2 years.
Luís Duarte-Gamas, António Pereira-Neves, Filipa Jácome, Mariana Fragão-Marques, Ricardo P. Vaz, Jose Paulo Andrade, João P. Rocha-Neves   +6 more
doaj   +1 more source

Feasibility and Procedural Considerations of Balloon‐Expandable TAVR in Patients With Prior Endovascular Aortic Stent Grafts

Catheterization and Cardiovascular Interventions, EarlyView.
ABSTRACT Objectives To evaluate the feasibility and short‐term outcomes of transcatheter aortic valve replacement (TAVR) using balloon‐expandable Sapien valves in patients with prior endovascular aortic stent grafts. Methods We conducted a single‐center, retrospective study of 23 patients with prior endovascular aortic stent grafts who underwent TAVR ...
Iad Alhallak, Alexander Mills, Beau Bequeaith, Ken Chan, Akiko Tanaka, Anthony L. Estrera, Biswajit Kar, Richard Smalling, Abhijeet Dhoble   +8 more
wiley   +1 more source

Interventional therapies for chronic heart failure: An overview of recent developments

ESC Heart Failure, Volume 12, Issue 2, Page 1081-1094, April 2025.
Abstract Heart failure (HF), the final manifestation of most cardiovascular diseases, has become a major global health concern, affecting millions of individuals. Despite basic drug treatments, patients present with high morbidity and mortality rates. However, recent advancements in interventional therapy have shown promising results in improving the ...
Bingchen Guo, Si Shi, Yutong Guo, Jie Xiong, Bo Wang, Zengxiang Dong, Dianyu Gao, Yingfeng Tu   +7 more
wiley   +1 more source

Ten-year outcome of chronic thromboembolic pulmonary hypertension patients in a tertiary center

Anatolian Journal of Cardiology, 2020
Objective: Chronic thromboembolic pulmonary hypertension (CTEPH) is one of the leading causes of pulmonary hypertension (PH). We aimed to investigate the outcome of CTEPH patients who were followed-up by a PH outpatient clinic.
Mehmet Serdar Küçükoğlu, Ümit Yaşar Sinan, Bedrettin Yıldızeli   +2 more
doaj   +1 more source

Pulmonary endarterectomy for chronic thromboembolic pulmonary hypertension: state-of-the-art 2020

Pulmonary Circulation, 2021
Pulmonary endarterectomy is the treatment of choice for patients with operable chronic thromboembolic pulmonary hypertension (CTEPH) as it is potentially curative.
Michael M. Madani
doaj   +1 more source

Emerging Human‐Based Research Technologies for Investigating the Pathomechanisms and Therapies for Vascular Diseases

iNew Medicine, EarlyView.
ABSTRACT It is estimated that a large proportion of drug candidates fail in human clinical trials, mainly because animal models cannot fully replicate human disease and because of differential responses to various medications between humans and animals.
Weiping Ding, Iqra Ilyas, Suowen Xu
wiley   +1 more source

Mass Spectrometry‐Based Extracellular Vesicle Proteomics for Biomarker Discovery

Mass Spectrometry Reviews, EarlyView.
ABSTRACT Extracellular vesicle (EV) proteomics has emerged as a powerful platform for decoding intercellular communication and advancing biomarker discovery across human diseases. EVs carry proteins that reflect their cells of origin, offering a minimally invasive window into physiological and pathological processes.
Ya‐Juan Liu, Juan Peng, Chao Kang
wiley   +1 more source