Results 41 to 50 of about 56,743 (265)

The role and implications of mammalian cellular circadian entrainment

FEBS Letters, EarlyView.
At their most fundamental level, mammalian circadian rhythms occur inside every individual cell. To tell the correct time, cells must align (or ‘entrain’) their circadian rhythm to the external environment. In this review, we highlight how cells entrain to the major circadian cues of light, feeding and temperature, and the implications this has for our
Priya Crosby
wiley   +1 more source

Molecular bases of circadian magnesium rhythms across eukaryotes

FEBS Letters, EarlyView.
Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley   +1 more source

Theoractive Learning towards Academic Endeavour [PDF]

Journal of Interdisciplinary Sciences, 2018
Theoractive learning is an essential ingredient that can complement various academic theories, making them easier to apply to a learning environment. Although it appears that theoractive learning is the effect of the beneficial causes of teaching and ...
Mani Man Singh Rajbhandari
doaj  

Allocating Unique Property Reference Numbers (UPRNs) to general practitioner-recorded patient addresses using a deterministic address-matching algorithm: evaluation of representativeness and bias in an ethnically-diverse inner city population

International Journal of Population Data Science, 2019
Background with rationale Pseudonymised UPRNs based on patient addresses can be used to link environmental information to electronic health records (EHRs), however the representativeness and potential demographic or health-related biases in linkage using
Gill Harper, David Stables, Kambiz Boomla, John Robson, Richard Fry, Zaheer Ahmed, Carol Dezateux   +6 more
doaj   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Immunisation of koalas against Chlamydia pecorum results in significant protection against chlamydial disease and mortality

npj Vaccines
In 2022, the Australian Government listed the koala as endangered in several states due to habitat destruction, traffic strikes, dog attacks, and Chlamydia pecorum disease. This study evaluates a 10-year assessment of a Major Outer Membrane Protein-based
Samuel Phillips, Jon Hanger, Julien Grosmaire, Ahmed Mehdi, Martina Jelocnik, Jessie Wong, Peter Timms   +6 more
doaj   +1 more source

Nursing: An essential expression of human endeavour

Curationis, 1982
To put nursing into some sort of perspective a brief historical journey is called for. History allegedly helps us to understand the present and even forecast the future through an awareness of past errors. Much depends on one’s source materials and it is
P.H. Harrison
doaj   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

Reconversión del QNH de aviación en presión atmosférica.

Revista Técnica de la Facultad de Ingeniería, 2014
La presente nota técnica abarca cálculos que permiten la reconversión del valor aeroportuario del QNH (hPa) de aviación en su correspondiente valor de presión atmosférica P (hPa) con ayuda de la atmósfera estándar OACI y de la altitud H (msnm) del ...
Luis Guillermo Hidalgo, Jesús Alfonso Hidalgo   +1 more
doaj