Results 111 to 120 of about 3,180 (229)

Lifetime and world-time in accelerated medicine. An essay on the consolation of synchronisation. [PDF]

Med Health Care Philos
Wiesing U.
europepmc   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

A synergistic drug combination that aids our battle against anaplastic thyroid carcinoma: a case report and discussion. [PDF]

Hormones (Athens)
Chumbiauca E, Valdés Calero I, López Picazo JM, Moreno-Jiménez M, Argueta A, Lozano MD, Duntas L, Galofré JC.   +7 more
europepmc   +1 more source

Yeast Gcn2 retains activity following humanization of its auto‐phosphorylation region

FEBS Open Bio, EarlyView.
Using Saccharomyces cerevisiae as a model to study Gcn2 activation and regulation is limited by the lack of antibodies detecting phosphorylated Gcn2. To overcome this, we engineered Gcn2‐HsC, a yeast Gcn2 variant recognizable by commercial anti‐human phospho‐GCN2 antibodies.
Reuben A. Anderson, Anja H. Schiemann, Evelyn Sattlegger   +2 more
wiley   +1 more source

Carfilzomib-induced sinus bradycardia: A case report and literature review. [PDF]

SAGE Open Med Case Rep
Zhao X, Sun D, Xu R, Qiu Y, Zhao S, Guo C, Chang C, Zhang J.   +7 more
europepmc   +1 more source

A Visual Speech Intelligibility Benefit Based on Speech Rhythm. [PDF]

Brain Sci, 2023
Kawase S, Davis C, Kim J.
europepmc   +1 more source

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source

Tephra seismites-Understanding seismic hazard of hidden faults by analyzing liquefied tephra layers in lakes. [PDF]

Sci Adv
Kluger MO, Melchert RA, Moratalla JM, Ilanko T, Lowe DJ, Moon VG, Villamor P, Chaneva J, Ross N, Orense RP.   +9 more
europepmc   +1 more source

Optimizing photoexcitation conditions for time‐resolved X‐ray solution scattering experiments

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering (TR‐XSS) is a powerful technique to visualize how proteins change their structure in real time after light activation. Selecting the right laser photoexcitation conditions—fluence, excitation geometry, and sample refresh rate—is critical to maximize the experimental signal while avoiding unwanted side effects ...
Matteo Levantino
wiley   +1 more source

Drosophila melanogaster larvae generate force to counteract external mechanical pressure. [PDF]

J Exp Biol
Ding Y, Lu Y, Zhao G, Gong Z.
europepmc   +1 more source