Results 151 to 160 of about 1,829,608 (298)

Viral Dynamic Model‐Informed Dose Selection of Mosnodenvir Prophylaxis against DENV‐3 in a Controlled Human Infection Model

Clinical Pharmacology &Therapeutics, EarlyView.
Dengue virus (DENV) infection is a significant global health threat. Mosnodenvir (JNJ‐64281802) is a pan‐serotype small molecule antiviral blocking DENV replication. A Phase IIa study (NCT05048875) evaluated the antiviral activity, safety, and pharmacokinetics of mosnodenvir as prophylaxis against DENV‐3 in a controlled human infection model (CHIM).
Nele Goeyvaerts, Xavier Woot de Trixhe, Martine Neyens, Thomas N. Kakuda, Liesbeth Van Wesenbeeck, Annemie Buelens, Freya Rasschaert, Anna Durbin, Oliver Ackaert   +8 more
wiley   +1 more source

Extracts of select endemic plants from the Republic of Mauritius exhibiting anti-cancer and immunomodulatory properties. [PDF]

Sci Rep, 2021
Kauroo S, Govinden-Soulange J, Ranghoo-Sanmukhiya VM, Miranda K, Cotham WE, Walla MD, Nagarkatti M, Nagarkatti P.   +7 more
europepmc   +1 more source

The Governance Gap: Democratizing Drug Development Through Decision Architecture

Clinical Pharmacology &Therapeutics, EarlyView.
Drug development is most exposed to governance failure where it can least afford it, in global health. The field has more predictive power than at any point in its history and roughly the same failure rate it had a decade ago. We argue that this paradox persists because the field has invested heavily in prediction science while neglecting decision ...
Craig R. Rayner, Nancy E. Martin, Danielle Smith, Eliza Kruger, Carl M.J. Kirkpatrick, Goonaseelan (Colin) Pillai, Katy Moore, Darrell Nix, Cristina Donini, Jakob P. Cramer, Edmundo Muniz, Natalia Muniz, Ernst Bos, Douglas McNair, Shyam Bhaskaran, Mark Sullivan, Dan Hartman   +16 more
wiley   +1 more source

Agro-Alimentary Potential of the Neglected and Underutilized Local Endemic Plants of Crete (Greece), Rif-Mediterranean Coast of Morocco and Tunisia: Perspectives and Challenges. [PDF]

Plants (Basel), 2021
Libiad M, Khabbach A, El Haissoufi M, Anestis I, Lamchouri F, Bourgou S, Megdiche-Ksouri W, Ghrabi-Gammar Z, Greveniotis V, Tsiripidis I, Dariotis E, Tsiafouli MA, Krigas N.   +12 more
europepmc   +1 more source

Organising Innovation as a New Commons: Eliciting Perspectives, Practices and Tensions in Multi‐Stakeholder Experimentations

Corporate Social Responsibility and Environmental Management, EarlyView.
ABSTRACT This paper explores how innovation is organised as a new commons within place‐based experimental settings characterised by institutional plurality. Drawing on scholarship on commons, commoning, and transformative innovation, we approach innovation as a collectively produced resource whose organisation becomes complex in contexts where market ...
Giulia Rossi, Enrico Bellazzecca, Irene Bengo   +2 more
wiley   +1 more source

Medicinal-Cosmetic Potential of the Local Endemic Plants of Crete (Greece), Northern Morocco and Tunisia: Priorities for Conservation and Sustainable Exploitation of Neglected and Underutilized Phytogenetic Resources. [PDF]

Biology (Basel), 2021
Bourgou S, Ben Haj Jilani I, Karous O, Megdiche-Ksouri W, Ghrabi-Gammar Z, Libiad M, Khabbach A, El Haissoufi M, Lamchouri F, Greveniotis V, Avramakis M, Hatzilazarou S, Anestis I, Tsoktouridis G, Krigas N.   +14 more
europepmc   +1 more source

Invasive alien plants in Europe - how can they be regulated?

, 2005
Invasive alien plants can be injurious to other plants - this provides the chance to regulate them as "plant pests" within the framework of plant health.
Schrader, Gritta
core  

Velociraptor Machine Learning Quantifies Similarity to Known Cell Types and Matches Cells Across Flow and Imaging Cytometry Platforms

Cytometry Part A, EarlyView.
ABSTRACT Suspension flow cytometry enables high‐throughput cellular profiling at the single cell level, but these data lack positional information. Conversely, tissue‐based imaging cytometry techniques reveal a cell's location within the tissue architecture and can provide insight into cell biology.
Claire E. Cross, Asa A. Brockman, Rebecca A. Ihrie, Jonathan M. Irish   +3 more
wiley   +1 more source

The projected risk of plant invasions on the peri‐Antarctic islands under climate change

Ecography, EarlyView.
The peri‐Antarctic islands have largely been shielded from alien plant species due to low human pressure, limited introduction pathways, and local harsh climates. However, climate change is expected to lower these barriers. We assess the vulnerability of 12 peri‐Antarctic islands to invasion by 2220 plant species invasive in at least one region of the ...
Tom Vorstenbosch, Franz Essl, Bernd Lenzner, Johannes Wessely, Wayne Dawson, Mark van Kleunen, Jan Pergl, Petr Pyšek, Stefan Dullinger   +8 more
wiley   +1 more source

Flowering plant wealth of sand dunes and coastal areas of Kanniyakumari District, Tamil Nadu, India

Environment Conservation Journal
Qualitative floristic surveys were conducted in the sand dunes and coastal areas of Kanniyakumari district, one of the coastal districts of Tamil Nadu.
Sugaseelan Akash , Velpandi Venkadeshraja, Muthulingam Udayakumar   +2 more
doaj   +1 more source