Results 281 to 290 of about 55,881 (343)

Lower Dose‐Normalized Tacrolimus Exposure in CYP3A5*6 vs. *3 Loss‐of‐Function Allele Carriers: A Longitudinal Retrospective Real‐World Study in Kidney Transplant Recipients

Clinical Pharmacology &Therapeutics, EarlyView.
Pharmacogenomic research has historically focused on individuals of European ancestry, leading to the underrepresentation of genetic variants common in non‐European populations. This bias is exemplified by CYP3A5*6, a functionally consequential variant common in individuals of African ancestry (MAF: 11–19%) but virtually absent in Europeans (MAF: 0.15%)
Amar D. Levens, Dirk Jan A. R. Moes, Yanick Boer, Aiko P. J. de Vries, Dorottya K. de Vries, Danny van der Helm, Soufian Meziyerh, Dave L. Roelen, Stefan Böhringer, Teun Van Gelder, Jesse J. Swen   +10 more
wiley   +1 more source

Unraveling Biogeographic Boundaries Within the Sierra Madre Oriental, México: An Endemicity Analysis Using a Taxonomically Diverse Dataset. [PDF]

Ecol Evol
Goyenechea Mayer-Goyenechea I, Montiel-Canales G, Márquez J, Hornung-Leoni CT, Castillo-Cerón JM, Manríquez-Morán NL.   +5 more
europepmc   +1 more source

Pharmacogenomics of Major Depressive Disorder in Indigenous Amazonian Populations

Clinical Pharmacology &Therapeutics, EarlyView.
Major depressive disorder is a highly prevalent psychological disorder worldwide and its main treatment is the use of Selective Serotonin Reuptake Inhibitors. However, few studies have demonstrated the relationship between the presence of genetic variants in pharmacogenes and the efficacy of these drugs, especially in populations with a unique genetic ...
Kaio Evandro Cardoso Aguiar, Natasha Monte da Silva, Juliana Carla Gomes Rodrigues, André Maurício Ribeiro‐dos‐Santos, Sandro José de Souza, Ândrea Ribeiro‐dos‐Santos, João Farias Guerreiro, Sidney Emanuel Batista dos Santos, Marianne Rodrigues Fernandes, Ney Pereira Carneiro dos Santos   +9 more
wiley   +1 more source

Conservation diplomacy as part of multilateral strategies for global peace and sustainability. [PDF]

NPJ Biodivers
Pandit MK.
europepmc   +1 more source

Measuring the Impact of the Substitution of Innovator Biologics With Biosimilars on Uptake and Costs Among Ontario Public Drug Benefit Recipients

Clinical Pharmacology &Therapeutics, EarlyView.
In Ontario, biologics have historically represented a small proportion of public drug claims but a large proportion of spending. Biosimilars, lower cost alternatives to biologics, offer a potential solution to the rising spending on biologics. From March 2023 to January 2024, the Ontario Ministry of Health required public drug program beneficiaries on ...
Anita Iacono, Martin K. H. Ho, Joanna Yang, Tonya Campbell, William Wynne, Dana Shearer, Lene Andersen, Eric Majer, Shaleesa Ledlie, Mina Tadrous, Tara Gomes   +10 more
wiley   +1 more source

Endemism in Indian Grasses-Tribe Andropogoneae

Ajay Mehrotra, S. K. Jain
openalex   +1 more source

Practice Insight: Adapting Peacebuilding Dialogue Methodologies to City‐Resident Relations and Inclusive Policymaking in Calgary, Canada

Conflict Resolution Quarterly, EarlyView.
ABSTRACT This case study presents a project in which peacebuilding dialogue methodologies were adapted for use in municipal‐level dialogue sessions that took place in Calgary, Canada in late 2022 and early 2023. The authors found that using this approach built trust among cross‐sectoral participants and facilitators, resulted in greater diversity ...
Aleem Bharwani, Josh Nadeau
wiley   +1 more source

Taxonomic diversity of green plants (Viridiplantae) in the Caatinga Phytogeographic Domain: a study supported by environmental licensing. [PDF]

Biodivers Data J
Cotarelli VM, de Moura-Júnior EG, Lima LF, Fontana AP, Cruz LC, Rodrigues RG, Pifano DS.   +6 more
europepmc   +1 more source

Global species richness of dragonflies and damselflies (Odonata): latitudinal trends and insular colonization. [PDF]

PeerJ
Cordero-Rivera A.
europepmc   +1 more source

Profile of Sharon Y. Strauss. [PDF]

Proc Natl Acad Sci U S A
Viegas J.
europepmc   +1 more source