Results 201 to 210 of about 1,087,207 (293)

Chronic Hypoxia Disrupts Spermatogenesis Through ASXL2–EZH2–Mediated Microtubule Destabilization

Advanced Science, EarlyView.
This study reveals the mechanism by which chronic hypoxia impairs spermatogenesis via the ASXL2–EZH2 axis, hindering the transition of spermatids from round to elongated forms. Key findings reveal that under hypoxic conditions, downregulated ASXL2 expression reduces EZH2 binding to the CEP162 promoter, leading to decreased H3K27me3 modification and ...
Jun Yin, Mengjie Zhang, Wenying Liu, Wenlong Shen, Debao Li, Hongming Miao, Fang Deng, Gang Zhang, Yi Tian, Yi Zhang, Zhihu Zhao, Bing Ni   +11 more
wiley   +1 more source

New approach methodologies (NAMs) for improved developmental and reproductive toxicity (DART) assessment with focus on endocrine disruption - a PARC project. [PDF]

Front Toxicol
Ardenkjær-Skinnerup J, Baert Y, Bajard L, Blum J, Brion F, Coppola L, Fini JB, Fritsche E, Holbech H, Hurem S, Jacobs MN, Johansson HKL, Knapen D, Koch K, Lyche JL, Mai PNT, Neuhaus W, Nikolov NG, Nurani A, Papageorgiou K, Poulsen R, Ramhøj L, Řehůřková E, Rosenmai AK, Rüegg J, Sovadinová I, Tait S, Van de Pette M, Vanhaecke T, Vergauwen L, Wedebye EB, Xu EG, Svingen T.   +32 more
europepmc   +1 more source

Indole‐3‐Propionic Acid Improves Alveolar Development Impairment via Targeting VAMP8‐mediated SNAREs Complex Formation in Bronchopulmonary Dysplasia

Advanced Science, EarlyView.
This study aims to evaluate the impact of the tryptophan‐derived metabolite indole‐3‐propionic acid (IPA) on lung development and autophagic flux. IPA alleviates hyperoxia‐induced alveolar arrest by promoting autophagosome‐lysosome fusion via inhibition of VAMP8 phosphorylation, which is suggestive of a promising therapeutic target of BPD.
Beibei Wang, Xu Chen, Haowei Xu, Zhiqi Zeng, Keyu Lu, Yu Mao, Qianru Lv, Hui Shi, Song Liu, Xian Shen, Chunyu Yin, Yang Yang, Yan Guo, Xingyun Wang, Rui Cheng   +14 more
wiley   +1 more source

Advances and challenges in studying effects of EDCs on tissue-resident macrophages in inflammation. [PDF]

J Endocr Soc
Bell MR, Walker KA, Valdez GM, Dressel CE.   +3 more
europepmc   +1 more source

Integrated Transcriptomics Reveals Evolutionary Trajectories and Cell Density‐Dependent Mechanisms in Aldosterone‐Producing Adenomas

Advanced Science, EarlyView.
Aldosterone‐producing adenomas (APAs) develop via two distinct paths: directly from adrenal zona glomerulosa (zG) cells, or stepwise from zG cells through aldosterone‐producing micronodules (APMs) before progressing to APAs. Advanced single‐cell and spatial analyses identified distinct cell states linked to oxidative stress and cell–cell interactions ...
Zhuolun Sun, Changying Jing, Martina Tetti, Siyuan Gong, Jia Wei, Yingxian Pang, Martin Reincke, Tracy Ann Williams   +7 more
wiley   +1 more source

Understanding the Endocrine and Reproductive Health Effects Associated With Exposures to Jet Fuels: A Fit-for-Purpose Systematic Literature Review. [PDF]

J Occup Environ Med
Prince LM, Cameron RL, Jester DJ, Assefa MT, Staggs H, Adamson MM, Goodman SJ, Snow SJ, Eftim SE, Vincent-Hall TD.   +9 more
europepmc   +1 more source

Ovarian Matrisome Dynamics and αvβ3‐Mediated Regulation in Early Follicular Development

Advanced Science, EarlyView.
The matrisome undergoes dynamic remodeling during early follicular development. Integrin αvβ3 mediates matrisome signals, regulating primordial follicle activation/atresia and secondary follicle growth via Hippo/mTOR pathways, with conserved roles in human ovaries, offering therapeutic targets for ovarian disorders.
Tong Wu, Yanzhi Feng, Qingqing Zhu, Ting Jiang, Yueyue Gao, Kebing Nie, Xianan Tang, Ying Chen, Dianxing Hu, Xudan Yang, Shixuan Wang, Meng Wu, Jinjin Zhang   +12 more
wiley   +1 more source

Defining prognostic subgroups and treatment outcomes in estrogen receptor low-positive de novo metastatic breast cancer. [PDF]

Breast Cancer Res Treat
Klugman MF, Aboumrad M, Chen R, Marshall CH, Canzoniero JV, Wolff AC, Visvanathan K.   +6 more
europepmc   +1 more source

Dynamics of the Mammalian Placental Metabolome in Placentogenesis and Embryonic Development

Advanced Science, EarlyView.
This study identifies three metabolic stages (E8.5, E9.5–10.5, E11.5–14.5) and two transition periods (E8.5–9.5, E10.5–11.5) in mouse placental development. NAD(H) emerges as a key dynamic metabolite that enhances embryonic growth through accelerated segmentation and increased proliferation of mouse embryonic stem cell (mESC)‐induced presomitic ...
Gang Chen, Zichen Liu, Mengyi Wei, Qian Li, Liang Wu, Kunyuan Yu, Yanhong Xu, Dainan Yu, Wenwu Ma, Hongmei Wang, Ng Shyh‐Chang, Jinglei Zhai   +11 more
wiley   +1 more source

Real-world patterns of post-progression treatment and outcomes in patients with HR+/HER2- advanced breast cancer treated with CDK4/6 inhibitors. [PDF]

Oncologist
Torrisi R, Giugliano F, Giordano L, Saltalamacchia G, Jacobs F, Carnevale Schianca A, Milano M, Bianco N, Sangalli CA, De Sanctis R, Masci G, Curigliano G, Santoro A, Munzone E.   +13 more
europepmc   +1 more source