Results 281 to 290 of about 9,843,586 (391)

Nanoparticle‐Mediated CXCL12–CXCR4 Inhibition Reprograms Macrophages and Suppresses Gastric Carcinoma

Advanced Science, EarlyView.
Molecular mechanism study of self‐assembled M2pep‐Cs NPs/Plerixafor nanoparticles in targeting MΦ reprogramming by regulating the CXCL12–CXCR4 signaling pathway to enhance immune recognition and clearance of GC (Created by BioRender). Abstract Gastric carcinoma (GC) remains a major global health challenge, requiring novel therapeutic approaches.
Qianqian Cao, Xiaolei Cheng, Rongbin Lv, Dianshui Sun, Jihua Wang, Runjia Fu, Rumei Gong, Yueying Xiao, Qin Liu, Xiaomei Li   +9 more
wiley   +1 more source

QSOX2‐Mediated Disulfide Bond Modification Enhances Tumor Stemness and Chemoresistance by Activating TSC2/mTOR/c‐Myc Feedback Loop in Esophageal Squamous Cell Carcinoma

Advanced Science, EarlyView.
High QSOX2 enhances stemness, drug resistance, and metastasis of ESCC cells. QSOX2‐mediated disulfide bond modification activates mTOR/c‐Myc signaling. CAFs‐secreted IGF‐1 drives mTOR/c‐Myc/QSOX2 positive feedback loop. Combining Ebselen, rapamycin, and cisplatin induces tumor dormancy in mice.
Wo‐Ming Chen, Xiao‐Ping Zhang, Xiao Sun, Hai‐Cheng Liu, Yuan‐Yuan Yan, Xue Wei, Yu Liang, Yue Feng, Zhengjie Chen, Yongxu Jia, Chen Jiang, Qian Yan, Lei Li   +12 more
wiley   +1 more source

Newly discovered endocrine functions of white adipose tissue: possible relevance in obesity-related diseases

, 2005
Alexander W. Krug, Monika Ehrhart‐Bornstein   +1 more
openalex   +1 more source

Functional annotation of ESR1 gene fusions in estrogen receptor-positive breast cancer [PDF]

, 2018
Crowder, Robert, Davies, Sherri R, et al,, Hoog, Jeremy, Iglesia, Michael, Li, Shunqiang, Ma, Cynthia X, Maher, Christopher A, Phommaly, Chanpheng, Rogers, Anna, Shao, Jieya, Watson, Mark A, Zhang, Jin   +12 more
core   +1 more source

Endocrine-disrupting chemicals and fatty liver disease

Nature Reviews Endocrinology, 2017
C. Foulds, L. Treviño, B. York, C. Walker   +3 more
semanticscholar   +1 more source

3D Brain Vascular Niche Model Captures Glioblastoma Infiltration, Dormancy, and Gene Signatures

Advanced Science, EarlyView.
This study developed a 3D brain vascular niche model that capture the key features of glioblastoma including perivascular infiltration, gene signature, dormancy and chemo resistance, by comparing 3D model with in vivo condition using identical glioma stem cells.
Vivian K. Lee, Rut Tejero, Nathaniel Silvia, Anirudh Sattiraju, Aarthi Ramakrishnan, Li Shen, Alexandre Wojcinski, Santosh Kesari, Roland H. Friedel, Hongyan Zou, Guohao Dai   +10 more
wiley   +1 more source

High Expression of <i>PKCζ</i> And <i>CTNNBIP1</i> Is Associated With Poor Prognosis in Luminal B Breast Cancer. [PDF]

Cancer Genomics Proteomics
Nagashima Y, Sasaki K, Chiwaki R, Ishii H, Nohata K, Maemura Y, Kasai T, Ozaki A, Tamori S, Ohno S, Akimoto K.   +10 more
europepmc   +1 more source

Possible Roles of B1 Cells and Environmental Estrogens (Endocrine Disruptors) in the Development of Autoimmune Diseases

, 2005
Sho Ishikawa
openalex   +1 more source

PFKM‐Driven Lactate Overproduction Promotes Atrial Fibrillation via Triggering Cardiac Fibroblasts Histone Lactylation

Advanced Science, EarlyView.
The upregulation of PFKM activates glycolysis, thereby enhancing lactate production in atrial tissue. Atrial lactate accumulation promotes global lactylation and H3K18 lactylation in atrial fibroblasts. P300‐mediated H3K18 lactylation up‐regulates TGF‐β1 transcription, leading to fibroblast activation and thereby contributing to atrial fibrosis.
Ning Fang, Ning Zhang, Xiaohui Jiang, Sen Yan, Zhiqi Wang, Qianhui Gao, Mingcheng Xu, Lin Mu, Xiaoming Li, Jiuling Chen, Song Zhang, Yu Duan, Fengxiang Yun, Luyifei Li, Yun Zhang, Yongtai Gong   +15 more
wiley   +1 more source

Insights from a multi-institutional registry show duration of endocrine treatment for DCIS impacts second events. [PDF]

NPJ Breast Cancer
O'Keefe TJ, Yau C, Iaconetti E, Jeong E, Brabham C, Kim P, McGuire J, Griffin A, Wallace AM, Esserman LJ, Harismendy O, Hirst GL.   +11 more
europepmc   +1 more source