Results 31 to 40 of about 378,071 (287)

Bulk and single-cell transcriptome analyses of islet tissue unravel gene signatures associated with pyroptosis and immune infiltration in type 2 diabetes

Frontiers in Endocrinology, 2023
IntroductionType 2 diabetes (T2D) is a common chronic heterogeneous metabolic disorder. However, the roles of pyroptosis and infiltrating immune cells in islet dysfunction of patients with T2D have yet to be explored.
Yaxian Song, Chen He, Yan Jiang, Mengshi Yang, Zhao Xu, Lingyan Yuan, Wenhua Zhang, Yushan Xu   +7 more
doaj   +1 more source

Lipid Metabolism Alterations in Hyperlipidemic Dogs with Biliary Tract or Endocrine Diseases

Animals
Fasting hyperlipidemia results from lipid metabolism defects associated with alterations in specific lipoprotein classes. These changes may originate from genetic predispositions or underlying metabolic disorders, including cholestasis and endocrine ...
Tae-Woo Kim, Min-Hee Kang, Hee-Myung Park   +2 more
doaj   +1 more source

Quality of life domains in patients with endocrine disorders: A study in the Al Jouf region of Saudi Arabia

Annals of Medical Science and Research
Introduction: Data on the burden of endocrine disease in the Al Jouf region of Saudi Arabia are not available. This work aims to describe the burden of endocrinopathies in residents of the Al Jouf region of Saudi Arabia.
Chikezie Hart Onwukwe, Queen Henry-Okafor   +1 more
doaj   +1 more source

Practical tools to identify short children born small-for-gestational-age eligible for rhGH treatment according to Italian regulation

Italian Journal of Pediatrics, 2019
Recombinant human growth hormone (rhGH) is an approved and effective treatment for short children born small for gestational age (SGA). Prevalence of children eligible for treatment as SGA is reported to be 1:1800.
Gianluca Tornese, Flavia Pricci, Maria Chiara Pellegrin, Marika Villa, Daniela Rotondi, Elvira Agazio, Egidio Barbi   +6 more
doaj   +1 more source

Identifying potential biomarkers for type 2 diabetes in the adipose tissue of older adults via multiple machine learning algorithms

Scientific Reports
Age-related decline in adipose tissue function is closely associated with impaired insulin sensitivity and chronic low-grade inflammation, and these conditions contribute to type 2 diabetes (T2D) development in older adults.
Yun-Sang Yu, Da Som Lee, Joo Hyun Lim, Yoo Jeong Lee   +3 more
doaj   +1 more source

Changes in Body Composition in Children and Young People Undergoing Treatment for Acute Lymphoblastic Leukemia: A Systematic Review and Meta‐Analysis

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Ongoing evidence indicates increased risk of sarcopenic obesity among children and young people (CYP) with acute lymphoblastic leukemia (ALL), often beginning early in treatment, persisting into survivorship. This review evaluates current literature on body composition in CYP with ALL during and after treatment.
Lina A. Zahed, Raquel Revuelta Iniesta, Mary Fewtrell, Julie Lanigan, Breeana Gardiner, Graeme O'Connor   +5 more
wiley   +1 more source

Vitamin D ameliorates age-induced nonalcoholic fatty liver disease by increasing the mitochondrial contact site and cristae organizing system (MICOS) 60 level

Experimental and Molecular Medicine
Nonalcoholic fatty liver disease (NAFLD) is the most common liver disease. Despite intensive research, considerable information on NAFLD development remains elusive.
Gyu Hee Kim, Hyeon-Ju Jeong, Yoo Jeong Lee, Hyeon Young Park, Soo Kyung Koo, Joo Hyun Lim   +5 more
doaj   +1 more source

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

Hematopoietic (stem) cells—The elixir of life?

FEBS Letters, EarlyView.
The aging of HSCs (hematopoietic stem cells) and the blood system leads to the decline of other organs. Rejuvenating aged HSCs improves the function of the blood system, slowing the aging of the heart, kidney, brain, and liver, and the occurrence of age‐related diseases.
Emilie L. Cerezo, Jonah Anderson, Emilie Dinh Vedrenne, Noël Yeh Martín, Jette Lengefeld   +4 more
wiley   +1 more source

Identification of Biomarkers Related to Metabolically Unhealthy Obesity in Korean Obese Adolescents: A Cross-Sectional Study

Children, 2023
Background: The current study aimed to screen for relationships and different potential metabolic biomarkers involved between metabolically healthy obesity (MHO) and metabolically unhealthy obesity (MUO) in adolescents.
Sarang Jeong, Han-Byul Jang, Hyo-Jin Kim, Hye-Ja Lee   +3 more
doaj   +1 more source