Results 61 to 70 of about 378,071 (287)

Global Barriers to Accessing Off-Patent Endocrine Therapies: A Renaissance of the Orphan Disease? [PDF]

, 2023
Nipun Lakshitha de Silva, Harsha Dissanayake, Sanjay Kalra, Karim Meeran, Noel Somasundaram, Channa Jayasena   +5 more
openalex   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Adherence to endocrine therapy and its relation to disease‐free survival among breast cancer patients visiting an out‐patient clinic at Khartoum Oncology Hospital, Sudan [PDF]

, 2020
Kamal Eldein Hamed Mohamed, Amany Elamin
openalex   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Large Right Atrial Myxoma With Endocrine Abnormalities as a Possible Case of a Syndromic Disease: A Case Report

Clinical Case Reports
The late onset of significant symptoms in this case provides valuable insight for future research on multiple neoplasia and endocrine syndromes, emphasizing the challenges of timely recognition.
Rozita Jalalian, Hannaneh Yousefi‐Koma, Soheil Azizi, Babak Bagheri, Rahman Ghafari, Yas Yousefi‐Koma   +5 more
doaj   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Prolactin deficiency drives diabetes-associated cognitive dysfunction by inducing microglia-mediated synaptic loss

Journal of Neuroinflammation
Background Diabetes-associated cognitive dysfunction, characterized by hippocampal synaptic loss as an early pathological feature, seriously threatens patients’ quality of life.
Jiaxuan Jiang, Pengzi Zhang, Yue Yuan, Xiang Xu, Tianyu Wu, Zhou Zhang, Jin Wang, Yan Bi   +7 more
doaj   +1 more source

Traditional Chinese medicine acupoint pasting for preventing and treating gastrointestinal reactions in type II diabetes mellitus patients undergoing glucagon-like peptide-1 receptor agonist therapy: A clinical study [PDF]

Journal of Medical Biochemistry
Background: Patients with type 2 diabetes mellitus (T2DM) initiating treatment with glucagon-like peptide-1 receptor agonists (GLP-1RAs) may encounter various risks and complications.
Zheng Songsong, Zhou Diyi, Chen Fangfang, Zheng Jiandi   +3 more
doaj   +1 more source

Day/night variations of myeloid and lymphoid cell subsets in the murine inguinal lymph node

FEBS Open Bio, EarlyView.
The circadian system is involved in the temporal regulation of the immune system. Our study reveals that two innate immune populations, NKT cells and neutrophils, predominate at the beginning of the day in healthy mice, highlighting how the time of day influences immune responses.
Paula M. Wagner, César G. Prucca, Lucia Boffelli, Virginia A. Piqueras, Silvia G. Correa, Mariana Maccioni, Mario E. Guido   +6 more
wiley   +1 more source

Muscle Diseases of Metabolic and Endocrine Derivation

Rheumato
Muscle function and pathology are complex subjects; the medical fields involved in their diagnosis and treatment represent rheumatology, physiatry and metabolic disease, among others.
Bruce Rothschild
doaj   +1 more source