Results 71 to 80 of about 9,843,586 (391)

Elucidation of chemical profiles and molecular targets of Mondia whitei leave fractions bioactive as novel therapeutics: an in vitro and in silico assay

Journal of Genetic Engineering and Biotechnology, 2022
Background Mondia whitei root is often used in Africa as a local therapeutic agent for libido enhancement. The fractions of the M. whitei leaves (MWL) lack chemical characterization of their bioactive components and possible molecular targets.
Hope Onohuean, Fanny Eseohe Onohuean, Sharon Iyobor Igbinoba, Joseph Obiezu Chukwujekwu Ezeonwumelu, Peter Chinedu Agu, Josiah Eseoghene Ifie, Tusubira Deusdedit, Patrick Maduabuchi Aja   +7 more
doaj   +1 more source

A Review of Equine Laminitis: Risk Factors and Predispositions [PDF]

, 2019
Equine laminitis is a disease of the hoof characterized by inflammation or disruption of the sensitive and insensitive laminae located within the hoof.
Henion, Molly C
core   +2 more sources

MANAGEMENT OF ENDOCRINE DISEASE: Polycystic ovary syndrome and nonalcoholic fatty liver disease.

European Journal of Endocrinology, 2017
Polycystic ovary syndrome (PCOS) is a frequent endocrine disease in women, with a number of metabolic and reproductive consequences. Obesity, insulin resistance (IR) and type 2 diabetes are prominent metabolic characteristics of PCOS and common factors ...
D. Macut, I. Božić-Antić, J. Bjekić-Macut, K. Tziomalos   +3 more
semanticscholar   +1 more source

Plasma lipidomic and metabolomic profiles in high‐grade glioma patients before and after 72‐h presurgery water‐only fasting

Molecular Oncology, EarlyView.
Presurgery 72‐h fasting in GB patients leads to adaptations of plasma lipids and polar metabolites. Fasting reduces lysophosphatidylcholines and increases free fatty acids, shifts triglycerides toward long‐chain TGs and increases branched‐chain amino acids, alpha aminobutyric acid, and uric acid.
Iris Divé, Lisa Hahnefeld, Katharina J. Wenger, Donat Kögel, Joachim Steinbach, Gerd Geisslinger, Michael W. Ronellenfitsch, Irmgard Tegeder   +7 more
wiley   +1 more source

Vitamin D ameliorates age-induced nonalcoholic fatty liver disease by increasing the mitochondrial contact site and cristae organizing system (MICOS) 60 level

Experimental and Molecular Medicine
Nonalcoholic fatty liver disease (NAFLD) is the most common liver disease. Despite intensive research, considerable information on NAFLD development remains elusive.
Gyu Hee Kim, Hyeon-Ju Jeong, Yoo Jeong Lee, Hyeon Young Park, Soo Kyung Koo, Joo Hyun Lim   +5 more
doaj   +1 more source

Association of Obesity and Hypertension: A Cohort Study in China

International Journal of Hypertension, 2021
The prevalence of general and central obesity has increased rapidly in China for decades, while little is known on obesity-normal weight-central obesity (NWCO) in China.
Xia Li, Huiqin Niu, XiaoGang Bai, YuWei Wang, Weihua Wang   +4 more
doaj   +1 more source

Vitamin D supplementation in the prevention and management of major chronic diseases not related to mineral homeostasis in adults : research for evidence and a scientific statement from the European society for clinical and economic aspects of osteoporosis and osteoarthritis (ESCEO) [PDF]

, 2017
Introduction: Optimal vitamin D status promotes skeletal health and is recommended with specific treatment in individuals at high risk for fragility fractures.
Bertoldo, Francesco, Bischoff-Ferrari, Heike A, Brandi, Maria Luisa, Bruyere, Olivier, Cianferotti, Luisella, Cooper, Cyrus, Cutolo, Maurizio, Kanis, John A, Kaufman, Jean, Reginster, Jean-Yves, Rizzoli, Rene   +10 more
core   +6 more sources

MANAGEMENT OF ENDOCRINE DISEASE: Pathogenesis and management of hypoglycemia.

European Journal of Endocrinology, 2017
Glucose is the main substrate utilized by the brain and as such multiple regulatory mechanisms exist to maintain glucose concentrations. When these mechanisms fail or are defective, hypoglycemia ensues.
Nana Esi N Kittah, A. Vella
semanticscholar   +1 more source

Thermal proteome profiling and proteome analysis using high‐definition mass spectrometry demonstrate modulation of cholesterol biosynthesis by next‐generation galeterone analog VNPP433‐3β in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Elevated level of cholesterol is positively correlated to prostate cancer development and disease severity. Cholesterol‐lowering drugs, such as statins, are demonstrated to inhibit prostate cancer. VNPP433‐3β interrupts multiple signaling and metabolic pathways, including cholesterol biosynthesis, AR‐mediated transcription of several oncogenes, mRNA 5′
Retheesh S. Thankan, Elizabeth Thomas, Mehari M. Weldemariam, Puranik Purushottamachar, Weiliang Huang, Maureen A. Kane, Yuji Zhang, Nicholas Ambulos, Bi‐Dar Wang, David Weber, Vincent C. O. Njar   +10 more
wiley   +1 more source

Predictive and Explainable Machine Learning Models for Endocrine, Nutritional, and Metabolic Mortality in Italy Using Geolocalized Pollution Data

Applied System Innovation
This study investigated the predictive performance of three regression models—Gradient Boosting (GB), Random Forest (RF), and XGBoost—in forecasting mortality due to endocrine, nutritional, and metabolic diseases across Italian provinces.
Donato Romano, Michele Magarelli, Pierfrancesco Novielli, Domenico Diacono, Pierpaolo Di Bitonto, Nicola Amoroso, Alfonso Monaco, Roberto Bellotti, Sabina Tangaro   +8 more
doaj   +1 more source