Results 161 to 170 of about 1,301,264 (280)

Tributyl phosphate as a type of environmental endocrine disruptor associated with liver fibrosis: insights from NHANES and <i>in vitro</i> validation. [PDF]

Front Toxicol
Yang L, Ju A, Huang Y, Jiang H, Ye J, Qi W, Zhou L.   +6 more
europepmc   +1 more source

Chronic Exposure to Endocrine Disruptor Vinclozolin Leads to Lung Damage via Nrf2-Nf-kb Pathway Alterations. [PDF]

Int J Mol Sci, 2022
D'Amico R, Di Paola D, Impellizzeri D, Genovese T, Fusco R, Peritore AF, Gugliandolo E, Crupi R, Interdonato L, Cuzzocrea S, Di Paola R, Siracusa R, Cordaro M.   +12 more
europepmc   +1 more source

PTG‐Dependent Glycogen Metabolic Dysfunction Drives Impaired Adipose Browning: A Novel Mechanism Linking PM2.5 to Metabolic Disorders

Advanced Science, EarlyView.
This study provides the first evidence that PM2.5 impairs iWAT browning via PTG‐mediated glycogen metabolism disruption, which is initiated by ADRB3 inhibition and subsequently triggers VEGFB upregulation. It thereby delineates the ADRB3‐PTG‐VEGFB axis as central to PM2.5‐induced metabolic dysfunction and identifies adipose glycogen metabolism as a ...
Limin Wang, Renjie Hu, Yanxi Chai, Ping He, Sanduo Li, Lisha Zhao, Wenbin Zhao, Lu Zhang, Li Qin, Ran Li, Xiaoli Hou, Qinghua Sun, Cuiqing Liu   +12 more
wiley   +1 more source

Endocrine disruptors

, 2006
An endocrine disruptor (ED) is a synthetic chemical that when absorbed into the body either mimics or blocks hormones and disrupts the body's normal functions. This disruption can happen through altering normal hormone levels, halting or stimulating the production of hormones, or changing the way hormones travel through the body, thus affecting the ...
openaire   +1 more source

Endocrine disruptor chemicals exposure and female fertility declining: from pathophysiology to epigenetic risks. [PDF]

Front Public Health
Tricotteaux-Zarqaoui S, Lahimer M, Abou Diwan M, Corona A, Candela P, Cabry R, Bach V, Khorsi-Cauet H, Benkhalifa M.   +8 more
europepmc   +1 more source

Modulation of Unfolded Protein Response Restores Survival and Function of β-Cells Exposed to the Endocrine Disruptor Bisphenol A. [PDF]

Int J Mol Sci, 2023
Daian LM, Tanko G, Vacaru AM, Ghila L, Chera S, Vacaru AM.   +5 more
europepmc   +1 more source

Divergent Regulatory Effects of Jasmonic Acid on Tomato Lycopene Biosynthesis Under Light and Dark Conditions

Advanced Science, EarlyView.
This study reveals the mechanism by which jasmonic acid (JA) regulates lycopene synthesis under light and dark conditions. In light, JA activates SlMYC2, which suppresses SlPIF1a and promotes SlPSY1 expression. In darkness, JA induces the acetyltransferase SlNATA1, which acetylates the dark‐accumulated SlPIF1a, thereby repressing SlPSY1 expression ...
Jiayi Xu, Lingfeng He, Jialong Zhang, Hao Cui, Hongxin Li, Haijun Zhang, Jiaojiao Zhang, Lun Liu, Kunpeng Xu, Yang‐Dong Guo, Na Zhang   +10 more
wiley   +1 more source

An in vitro approach reveals molecular mechanisms underlying endocrine disruptor-induced epimutagenesis. [PDF]

Elife
Lehle JD, Lin YH, Gomez A, Chavez L, McCarrey JR.   +4 more
europepmc   +1 more source

Reduced Survival and Disruption of Female Reproductive Output in Two Copepod Species (Acartia clausi and A. tonsa) Exposed to the Model Endocrine Disruptor 17α-Ethinylestradiol. [PDF]

Toxics, 2023
Hafez T, Villate F, Ortiz-Zarragoitia M.
europepmc   +1 more source

ERM Inhibition Confers Ferroptosis Resistance through ROS‐Induced NRF2 Signaling

Advanced Science, EarlyView.
ERM inhibition disrupts ERM‐actin interactions, elevating ROS and triggering KEAP1 degradation, which stabilizes and activates NRF2. Nuclear NRF2 induces cytoprotective genes, notably HMOX1, enhancing redox buffering and suppressing lipid peroxidation to resist erastin‐induced ferroptosis.
Menghao Qiao, Liqun Zhou, Minhua Zhou, Yu Fang, Haiying Mai, Lingbo Cao, Kun Xu, Yuan Sang, Minyi Chen, Jiewei Huang, Peiyi Huang, Zhipeng Yan, Chao Wang, Zhangshuai Dai, Dichun Huang, Ronghan He, Lijuan Pang, Yunmiao Guo, Ting Gang Chew, Junqi Huang   +19 more
wiley   +1 more source