A Systematic Pan-Cancer Analysis of CASP3 as a Potential Target for Immunotherapy
Frontiers in Molecular Biosciences, 2022 CASP3 is the gene encoding caspase-3, a specific protease that cleaves substrates such as poly-ADP ribose polymerase and acetyl-DEVD-7-amino-4-methylcoumarin. This enzymatic activity leads to DNA fragmentation, which is a hallmark of apoptosis.
Zheng Zhou +9 more
doaj +1 more source
Timing of maternal exposure and fetal sex determine the effects of low-level chemical mixture exposure on the fetal neuroendocrine system in sheep [PDF]
, 2016 We have shown that continuous maternal exposure to the complex mixture of environmental chemicals (ECs) found in human biosolids (sewage sludge), disrupts mRNA expression of genes crucial for development and long-term regulation of hypothalamo-pituitary ...
Bellingham, M. +7 more
core +2 more sources
Ligula intestinalis (Cestoda: Pseudophyllidea): an ideal fish-metazoan parasite model? [PDF]
, 2010 Since its use as a model to study metazoan parasite culture and in vitro development, the plerocercoid of the tapeworm, Ligula intestinalis, has served as a useful scientific tool to study a range of biological factors, particularly within its fish ...
Carter, V, Dufour, S, Hoole, D
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Level II lateral neck dissection for papillary thyroid carcinoma: A retrospective cohort study
Asian Journal of Surgery, 2023 Background: For N1b papillary thyroid carcinoma (PTC) patients, lateral neck dissection encompassing levels Ⅱ-Ⅴ is generally recommended. However, routine level Ⅱ dissection is controversial given the low incidence of metastasis, and potential ...
Tian Lv +8 more
doaj +1 more source
Sexual Differentiation of Circadian Clock Function in the Adrenal Gland [PDF]
, 2016 Sex differences in glucocorticoid production are associated with increased responsiveness of the adrenal gland in females. However, the adrenal-intrinsic mechanisms that establish sexual dimorphic function remain ill defined. Glucocorticoid production is
Evans, Jennifer A. +5 more
core +2 more sources
Environmental chemical exposures and breast cancer [PDF]
, 2016 As a hormone-sensitive condition with no single identifiable cause, breast cancer is a major health problem. It is characterized by a wide range of contributing factors and exposures occurring in different combinations and strengths across a lifetime ...
Plant, J, Stanley, E, Voulvoulis, N
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Endocrine Disrupting Chemicals: Effects on Endocrine Glands [PDF]
Frontiers in Endocrinology, 2019 In recent years, endocrine disrupting chemicals have gained interest in human physiopathology and more and more studies aimed to explain how these chemicals compounds affect endocrine system. In human populations, the majority of the studies point toward an association between exposure to endocrine disrupting chemicals and the disorders affecting ...
Lauretta R. +4 more
openaire +5 more sources
Robust data assimilation in river flow and stage estimation based on multiple imputation particle filter [PDF]
, 2019 In this paper, new method is proposed for a more robust Data Assimilation (DA) design of the river flow and stage estimation. By using the new sets of data that are derived from the incorporated Multi Imputation Particle Filter (MIPF) in the DA ...
Ismail, Zool Hilmi, Jalaludin, Nor Anija
core +1 more source
Multiple endocrine neoplasia type 4: a new member of the MEN family
Endocrine Connections, 2023 Objective: Multiple endocrine neoplasia type 4 (MEN4) is caused by a CDKN1B germline mutation first described in 2006. Its estimated prevalence is le ss than one per million. The aim of this study was to define the disease characteristics.
Hélène Singeisen +9 more
doaj +1 more source
Inter-population variability in the reproductive morphology of the shore crab (Carcinus maenas): Evidence of endocrine disruption in a marine crustacean? [PDF]
, 2005 Environmental contaminants that are capable of causing endocrine disrupting effects are currently a major cause for concern. These chemicals are known to influence the reproductive development of vertebrates by mimicking or antagonising the actions of ...
Brian, JV
core +1 more source