Results 101 to 110 of about 20,927,465 (328)

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Expression of the neural cell adhesion NCAM in endocrine cells of the ovary [PDF]

, 1991
In the adult mammalian ovary morphogenesis and differentiation processes are under hormonal control and, thus, occur in a highly regulated way during the sexual cycle.
Lahr, G., Gratzl, Manfred, Mayerhofer, Artur   +2 more
core   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Vitamin D and Neurological Diseases: An Endocrine View

International Journal of Molecular Sciences, 2017
Vitamin D system comprises hormone precursors, active metabolites, carriers, enzymes, and receptors involved in genomic and non-genomic effects. In addition to classical bone-related effects, this system has also been shown to activate multiple molecular
C. Di Somma, E. Scarano, L. Barrea, V. Zhukouskaya, S. Savastano, C. Mele, M. Scacchi, G. Aimaretti, A. Colao, P. Marzullo   +9 more
semanticscholar   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Toward the effective surveillance of hypospadias [PDF]

, 2004
Concern about apparent increases in the prevalence of hypospadias--a congenital male reproductive-tract abnormality--in the 1960s to 1980s and the possible connection to increasing exposures to endocrine-disrupting chemicals have underlined the ...
John E S Scott, Addor, Marie-Claude, Calzolari, Elisa, Addor, M.C., Nigel Physick, Botting, B., Loane, M, Scott, JES, Ester Garne, Elisa Calzolari, Physick, N., Stone, D, Romano Tenconi, Stone, David, Bev Botting, Dolk, H, Pierini, A, Marie-Claude Addor, Dolk, H., Pierini, Anna, Helen Dolk, Martine Vrijheid, Addor, MC, Maria Loane, Calzolari, E., Scott, J.E., Tenconi, R, Awi Wiesel, Hermien de Walle, David Stone, Garcia-Minaur, S, Physick, N, Physick, Nigel, Catherine de Vigan, Scott, John ES, de Vigan, Catherine, Garne, E., Garcia-Minaur, S., Loane, M., Pierini, A., Vrijheid, M., de Walle, H., Stone, D., Vrijheid, M, Tenconi, Romano, De, WH, Botting, Bev, Tenconi, R., Vrijheid, Martine, Wiesel, A, de Walle, Hermien, Anna Pierini, Garcia-Minaur, Sixto, Calzolari, E, Dolk, Helen, Garne, Ester, Wiesel, A., Wiesel, Awi, de, VC, de Vigan, C, de Vigan, C., de Walle, H, Garne, E, Botting, B, Sixto Garcia-Minaur, Loane, Maria   +65 more
core   +1 more source

Autoimmune Disease in Women: Endocrine Transition and Risk Across the Lifespan

Frontiers in Endocrinology, 2019
Women have a higher incidence and prevalence of autoimmune diseases than men, and 85% or more patients of multiple autoimmune diseases are female. Women undergo sweeping endocrinological changes at least twice during their lifetime, puberty and menopause,
Maunil K. Desai, Roberta Diaz Brinton, Roberta Diaz Brinton   +2 more
doaj   +1 more source