Results 211 to 220 of about 423,420 (336)

Metformin Restores Mitochondrial Function and Neurogenesis in POLG Patient‐Derived Brain Organoids

Advanced Science, EarlyView.
Patient‐derived POLG‐mutant cortical organoids reveal neuronal subtype‐specific mitochondrial and synaptic defects, with dopaminergic neurons most affected. Metformin treatment restores neuronal identity, mitochondrial function, and excitability, increased mtDNA maintenance, and reprogrammed metabolism via TCA and redox pathways.
Zhuoyuan Zhang, Tsering Yangzom, Ning Lu, Shenglong Deng, Xianglu Xiao, Guang Yang, Kristina Xiao Liang   +6 more
wiley   +1 more source

Impact of somatic comorbidities on healthcare costs in patients with severe mental disorders: a cross-sectional study in Beijing. [PDF]

BMC Psychiatry
Huang Q, Xin Y, Zhu J, Dong Y, Chen Y, Chen C, Lu W.   +6 more
europepmc   +1 more source

Replacing BPA: Structural Substitutes BPAF Binding to the Progesterone Receptor Elevates Breast Cancer Risk

Advanced Science, EarlyView.
This study demonstrates that bisphenol analogues, particularly BPAF, bind to progesterone receptor, promoting breast cancer cell proliferation, migration, and mammary tumor growth, indicating that bisphenol A substitutes may pose equal or greater health risks.
Xiaotong Ji, Peilin Li, Haoyang Wu, Linzhuo Shen, Xiaoyun Wu, Peiyun Jiang, Yating Li, Xiaozheng Zhang, Huifeng Yue   +8 more
wiley   +1 more source

Condition of neuro-endocrine system at comorbid course of chronic obstructive pulmonary disease and gastroesophageal reflux disease

, 2016
Т. В. Дудка, І. В. Дудка
openalex   +2 more sources

MEDICAL AND ENVIRONMENTAL ASPECTS EVOLUTION OF DISEASES OF THE ENDOCRINE SYSTEM IN CHILDREN OF UKRAINE

, 2023
О.П. Волосовец, Т.O. Kryuchko, Yu.V. Marushko, G.O. Lezhenko, T. M. Volosovets, S.P. Kryvopustov, І. Г. Дікова   +6 more
openalex   +1 more source

Sustainable diet studies show co-benefits for greenhouse gas emissions and public health.

, 2015
Auestad, Edenhofer, Green, Hallström, Vieux, Vieux, Wirsenius   +6 more
core   +1 more source

Epigenetic Targeting of Senescent Cells Prevents the Deleterious Effects of Obstructive Sleep Apnea on Growing Skeleton

Advanced Science, EarlyView.
Chronic intermittent hypoxia induces premature senescence of osteoprogenitor cells in long bone metaphysis via HIF1α‐mediated EZH2‐H3k27me3 downregulation, leading to impaired bone growth. Restoration of H3K27me3 level via UTX inhibition rescues osteogenesis and growth impairment in young mice.
Xiaonan Liu, Peilin Zhang, Zhongyi Su, Yong Feng, Zhenger Zhou, Sa Pang, Yicheng Wang, Jiacheng Hu   +7 more
wiley   +1 more source

Insights into the Genetic and Epigenetic Landscape of Endocrine Autoimmunity: A Systematic Review. [PDF]

Genes (Basel)
Tuli G, Munarin J, Davalos Flores KS, De Sanctis L.   +3 more
europepmc   +1 more source

Suicidal behavior with diseases of the endocrine system, eating disorders and metabolic disorders

Р. В. Бисалиев
openalex   +2 more sources

Chloroplast Fibrillin‐Mediated α‐Tocopherol Biosynthesis Impaired by a Virus to Enhance Infection and to Improve Drought Tolerance

Advanced Science, EarlyView.
ToCV‐encoded p22 targets chloroplast plastoglobules (PGs) via directly binding PG structural protein FBN1.1, reducing the size of PG and inhibiting α‐tocopherol biosynthesis via competing with tocopherol cyclase (VTE1). Consequently, the elevated chloroplast ROS not only creates a suitable cellular environment for efficient ToCV infection but also ...
Sijia Liu, Xuedong Liu, Qin Yan, Xi Chen, Lianyi Zang, Jingang Hu, Xiaoping Zhu, Zaifeng Fan, Tao Zhou   +8 more
wiley   +1 more source