Apremilast in Japanese patients with palmoplantar pustulosis: A randomized, Phase 3 trial
In this Phase 3 trial of Japanese patients with moderate to severe PPP (NCT05174065), significantly more patients achieved PPPASI‐50 at Week 16 with apremilast versus placebo. Patient‐reported outcomes, including pruritus and pain/discomfort, also showed significantly greater decreases at Week 16 with apremilast versus placebo.
Tadashi Terui +15 more
wiley +1 more source
Successful Regenerative Endodontic Therapy of a Dens Evaginatus Mandibular Second Premolar with an Acute Apical Abscess and Extensive Periapical Bone Loss: A Case Report. [PDF]
DeMayo FJ, Seagroves JT, Komabayashi T.
europepmc +1 more source
ABSTRACT Objectives To present and compare several extrusion techniques in case of insufficient tooth structure to create a sufficient ferrule and consider the biological width. Clinical Considerations Extrusion methods based on orthodontic or surgical techniques are commonly applied, well‐described, and predictable extrusion methods. Elastics with the
Elisabeth Völler +6 more
wiley +1 more source
To Evaluate Different Endodontic Instrumentation Systems Regarding Post-Operative Pain After Endodontic Therapy: A Clinical Study. [PDF]
Govindiah Chandra Mohan BG +5 more
europepmc +1 more source
Substance‐Gain Extrusion Technique (SGET) in Combination With BOPT—Technique Description
ABSTRACT Objective The restoration of teeth with deep subgingival fractures poses a significant challenge, often requiring extensive interventions such as orthodontic extrusion or implant therapy. This manuscript aims to introduce and describe the substance‐gain extrusion technique (SGET) as a minimally invasive alternative that enables the ...
M. Pirc +4 more
wiley +1 more source
Interdisciplinary Management of Open Interproximal Embrasures
ABSTRACT Objectives To describe key etiological and risk factors associated with open interproximal embrasures (OIE) and propose a systematic interdisciplinary approach for their management, emphasizing the integration of periodontics, orthodontics, and prosthodontics.
Yudai Ogawa +7 more
wiley +1 more source
Healing potentiality of blood clot, S-PRF and A-PRF as scaffold in treatment of non-vital mature single rooted teeth with chronic peri-apical periodontitis following regenerative endodontic therapy: randomized clinical trial. [PDF]
Darwish OB, Aziz SMA, Sadek HS.
europepmc +1 more source
ABSTRACT Objective The replacement of missing maxillary lateral incisors poses both functional and esthetic challenges, not only from a restorative but also from a periodontal aspect. This case report presents a step‐by‐step protocol for ideal hard and soft‐tissue esthetics with cantilever zirconia ceramic resin‐bonded fixed dental prostheses (RBFDPs).
Markus B. Blatz +3 more
wiley +1 more source
Evaluation of the modified 3Mix-Simvastatin combination in non-instrumental endodontic therapy of necrotic primary molars: A two-arm randomized controlled trial. [PDF]
Almarji W, Laflouf M, Tolibah YA.
europepmc +1 more source

