Results 251 to 260 of about 1,477,498 (302)

Tailoring Vascular‐Immune Homeostasis via Manganese‐DNA Complex‐Armed Immunogenic Extracellular Vesicles for Pancreatic Cancer Immunotherapy

Advanced Science, EarlyView.
This study demonstrates that Mn2⁺–tumor DNA complexes encapsulated in dendritic cell (DC)– derived immunogenic extracellular vesicles (EVDC@Mn‐DNA) act as a DC‐specific cGAS– STING activator. EVDC@Mn‐DNA treatment enhances intratumoral DC activation, improves tumor vascular function, promotes CD8⁺ T cell activity, and suppresses pancreatic tumor growth,
Xue Jiang, Lihuan Shang, Xiaochun Chen, Xiangzhan Kong, Xiaojuan Wang, Linjia Jiang, Huiying Zhao, Yafeng Zhu, Cheng Huang, Shiyi Deng, Rui Zhang, Minghui Wang, Haoming Lin, Ping‐Pui Wong   +13 more
wiley   +1 more source

Melatonin: a multifaceted regulator of root development, stress responses, and hormonal crosstalk in horticultural crops. [PDF]

Front Plant Sci
Liang C, Xu H, Li D, Ma C, Lv Y, Liu J.
europepmc   +1 more source

PD‐1 Inhibits CD4+ TRM‐Mediated cDC1 Mobilization via Suppressing JAML in Human NSCLC

Advanced Science, EarlyView.
CD4+ tissue‐resident memory T cells (TRMs) in non‐small cell lung cancer recruit conventional type 1 dendritic cells via XCL1‐XCR1 signaling, orchestrating antitumor immunity. The costimulatory molecule JAML is essential for this process. PD‐1 blockade restores JAML expression and cDC1 mobilization, while JAML agonists synergize with anti‐PD‐1 therapy,
Zheyu Shao, Qinyuan Liu, Zhongwei Xin, Zhiyao Zhou, Mingjie Lin, Di Chen, Zhixing Hao, Yongyuan Chen, Wenxuan Wu, Shuyang Zhang, Xiaoke Chen, Xia Xu, Jinfan Li, Wei Lin, Yuhao Lu, Dang Wu, Pin Wu   +16 more
wiley   +1 more source

Impact of kilning on the fermentability of oat wholemeal flour and related bioconversion of starch, protein, dietary fibre, and phytate. [PDF]

Curr Res Food Sci
Lambrechts E, Blontrock E, Gettemans T, Lemoine J, Vanhove S, De Bondt Y, Janssen F, Weckx S, De Vuyst L, Wouters AGB, Courtin CM.   +10 more
europepmc   +1 more source

Bromate reduction by <i>Shewanella</i> species depends on both endogenous and exogenous iron. [PDF]

Front Microbiol
Takahashi N, Fujiya H, Sato H, Yamamura S, Amachi S.   +4 more
europepmc   +1 more source

Expression of the <i>siss-1</i> gene in <i>C. elegans</i>. [PDF]

MicroPubl Biol
Barsegyan M, Van Buskirk C.
europepmc   +1 more source

Precision modeling of tumor antigen-specific T-cell responses in humanized mice for preclinical assessment of cancer immunotherapies. [PDF]

J Immunother Cancer
Gebhardt S, Le Clech M, Höllbacher B, Brunner S, Varol A, Lang S, Jenni S, Briner S, Yángüez E, Hüsser T, Domocos I, Tauscher R, Eckmann J, Münz C, Sam J.   +14 more
europepmc   +1 more source

Early birds and night owls: natural variation of circadian traits in plants. [PDF]

J Exp Bot
Feke A, Farré EM.
europepmc   +1 more source

Salmonella relies on siderophore exploitation at low pH. [PDF]

Microlife
Ferry M, Sharp C, Schalk IJ, Cunrath O.
europepmc   +1 more source