Results 71 to 80 of about 2,262,534 (280)

Research on Endogenous Security Defense for Cloud-Edge Collaborative Industrial Control Systems Based on Luenberger Observer

Mathematics
Industrial Control Systems (ICSs) are fundamental to critical infrastructure, yet they face increasing cybersecurity threats, particularly data integrity attacks like replay and data forgery attacks.
Lin Guan, Ci Tao, Ping Chen
doaj   +1 more source

Systematic Position Mapping of Split CRISPR‐Cas12a Activators Enables Highly Sensitive miRNA Detection and Cancer Cell Stratification

Advanced Science, EarlyView.
ABSTRACT Amplification‐free Cas12a diagnostics with split crRNA enable rapid and programmable target recognition, yet insufficient understanding of DNA activator architecture prevents predictable control over trans‐cleavage activity and sensitivity. Here we systematically map over 200 split DNA activator configurations by introducing nicks at every ...
Xiaoyan Tang, Zhe Li, Yuning Lu, Miao Ma, Zijian Mo, Jiajun Ke, Xinyu Luan, Tiangang Luan, Junqiu Zhai   +8 more
wiley   +1 more source

Endogenous fertility, endogenous lifetime and economic growth: the role of child policies [PDF]

We examine the effects of child policies on both the transitional dynamics and long-run demo-economic outcomes in the conventional overlapping generations model of neoclassical growth extended with endogenous longevity and endogenous fertility.
Gori, Luca, Fanti, Luciano
core  

2010 Annual Summary Report for the Area 3 and Area 5 Radioactive Management Sites at the Nevada National Security Site, Nye County, Nevada [PDF]

, 2011
The U.S. Department of Energy, National Nuclear Security Administration Nevada Site Office performed an annual review of the Area 3 and Area 5 Radioactive Waste Management Site (RWMS) Performance Assessments (PAs) and Composite Analyses (CAs) in fiscal ...
National Security Technologies, LLC
core   +1 more source

Decentralized Dynamic Heterogeneous Redundancy Architecture Based on Raft Consensus Algorithm

Future Internet
Dynamic heterogeneous redundancy (DHR) architectures combine heterogeneity, redundancy, and dynamism to create security-centric frameworks that can be used to mitigate network attacks that exploit unknown vulnerabilities.
Ke Chen, Leyi Shi
doaj   +1 more source

Rewiring Pyroptosis to Potentiate Cancer Immunotherapy via a Gasdermin D Agonist Bypassing Caspase‐3

Advanced Science, EarlyView.
This work introduces a small‐molecule agonist, DIBDO, that bypasses Casp‐3 to directly trigger GSDMD‐mediated pyroptosis in tumors. Activated by glutathione, DIBDO generates singlet oxygen and molecular iodine, blocking Casp‐3 pathways and inducing immunogenic cell death.
Dan Zhao, Lingling Zhang, Yue Wen, Lianghui Cheng, Sidan Tian, Fanling Meng, Liang Luo   +6 more
wiley   +1 more source

Theoretical Foundations and Architectural Evolution of Cyberspace Endogenous Security: A Comprehensive Survey

Applied Sciences
The endogenous security paradigm has emerged to address the limitations of traditional cybersecurity, which relies on reactive “patching” and struggles against unknown threats, APTs, and supply chain attacks.
Heming Zhang, Jian Li, Hong Wang, Shizhong Xu, Hong Yang, Haitao Wu   +5 more
doaj   +1 more source

Therapeutic Gene Editing of APOE4 in Sporadic Alzheimer's Disease via Prime Editor 7

Advanced Science, EarlyView.
Prime Editor 7‐mediated conversion of APOE4 to APOE3 alleviates Alzheimer's disease‐associated pathology in AD mouse models and patient‐derived neurons and improves cognitive performance in vivo, supporting therapeutic genome editing as a promising strategy for APOE4‐associated neurodegeneration.
Yunkyung Kim, Gaeun Lee, Saemin An, Hanseul Park, Hongwon Kim, Jisung Kim, Soi Kang, Sumin Kim, Daeyeol Kwon, Jeonghyun Park, Yerim Hwang, Seonghun Kim, Xiuwen Yuan, Jaehoon Jeong, Hamin Lee, Hui Kwon Kim, Jongpil Kim   +16 more
wiley   +1 more source

Endogenous fertility and development traps with endogenous lifetime [PDF]

We extend the literature on endogenous lifetime and economic growth by Chakraborty (2004) and Bunzel and Qiao (2005) to endogenous fertility. It is shown that development traps due to under investments in health can never appear when fertility is an ...
Gori, Luca, Fanti, Luciano
core  

Event-Triggered Finite-Time Consensus Scheme for Time-Delay Multi-Agent Systems with Settling Time Estimation and its Application

Journal of Aerospace Technology and Management
This study addresses the finite-time formation control issues associated with time-delay multi-agent systems. To tackle the challenges of finite-time stability in delay systems, Artstein’s transformation is utilized.
Haini Zhang, Ding Zhou
doaj